NRF2 Knockdown Resensitizes 5-Fluorouracil-Resistant Pancreatic Cancer Cells by Suppressing HO-1 and ABCG2 Expression

Chemoresistance is a leading cause of morbidity and mortality in patients with pancreatic cancer and remains an obstacle to successful treatment. The antioxidant transcription factor nuclear factor (erythroid-derived 2)-related factor 2 (NRF2), which plays important roles in tumor angiogenesis and i...

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Veröffentlicht in:	International journal of molecular sciences 2020-06, Vol.21 (13), p.4646
Hauptverfasser:	Kim, Eui Joo, Kim, Yoon Jae, Lee, Hye In, Jeong, Seok-Hoo, Nam, Hyo Jung, Cho, Jae Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Adenocarcinoma Angiogenesis Antioxidants Antioxidants - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism ATP-Binding Cassette Transporters - metabolism Biotechnology Breast cancer Cancer therapies Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Cell Movement - genetics Cell Survival - genetics Chemoresistance Chemotherapy Dehydrogenases Drug resistance Drug Resistance, Neoplasm - genetics Drug Resistance, Neoplasm - physiology Epithelial-Mesenchymal Transition Esophageal cancer Fluorouracil - pharmacology Gene Expression Regulation, Neoplastic - genetics Gene Knockdown Techniques - methods Heme Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Humans Invasiveness Lung cancer Markers Mesenchyme Metastasis Morbidity Neoplasm Invasiveness - genetics Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oct-4 protein Oxygenase Pancreas - metabolism Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Quinones Stem cells Superoxide dismutase Tumors
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