Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions

The difficulty of achieving robust functional expression of insect nicotinic acetylcholine receptors (nAChRs) has hampered our understanding of these important molecular targets of globally deployed neonicotinoid insecticides at a time when concerns have grown regarding the toxicity of this chemotyp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-07, Vol.117 (28), p.16283-16291
Hauptverfasser:	Ihara, Makoto, Furutani, Shogo, Shigetou, Sho, Shimada, Shota, Niki, Kunihiro, Komori, Yuma, Kamiya, Masaki, Koizumi, Wataru, Magara, Leo, Hikida, Mai, Noguchi, Akira, Okuhara, Daiki, Yoshinari, Yuto, Kondo, Shu, Tanimoto, Hiromu, Niwa, Ryusuke, Sattelle, David B., Matsuda, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Bees Biological Sciences Bumblebees Fruit flies Fruits Gametocytes Insecticides Insects Neonicotinoid insecticides Oocytes Pesticides Pollinators Receptors Robustness Thioredoxin Toxicity
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