Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes

Salicyl-AMS (1) is a potent inhibitor of salicylate adenylation enzymes used in bacterial siderophore biosynthesis and a promising lead compound for the treatment of tuberculosis. An optimized, multigram synthesis is presented, which provides salicyl-AMS as its sodium salt (1·Na) in three synthetic...

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Hauptverfasser:	Kinarivala, Nihar, Standke, Lisa C, Guney, Tezcan, Ji, Cheng, Noguchi, Naoyoshi, Asano, Yasutomi, Tan, Derek S
Format:	Buchkapitel
Sprache:	eng
Online-Zugang:	Volltext
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