Body composition analysis using CT and MRI: intra-individual intermodal comparison of muscle mass and myosteatosis
Computed tomography (CT) and magnetic resonance imaging (MRI) can quantify muscle mass and quality. However, it is still unclear if CT and MRI derived measurements can be used interchangeable. In this prospective study, fifty consecutive participants of a cancer screening program underwent same day...
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creator | Faron, Anton Sprinkart, Alois M. Kuetting, Daniel L. R. Feisst, Andreas Isaak, Alexander Endler, Christoph Chang, Johannes Nowak, Sebastian Block, Wolfgang Thomas, Daniel Attenberger, Ulrike Luetkens, Julian A. |
description | Computed tomography (CT) and magnetic resonance imaging (MRI) can quantify muscle mass and quality. However, it is still unclear if CT and MRI derived measurements can be used interchangeable. In this prospective study, fifty consecutive participants of a cancer screening program underwent same day low-dose chest CT and MRI. Cross-sectional areas (CSA) of the paraspinal skeletal muscles were obtained. CT and MRI muscle fat infiltration (MFI) were assessed by mean radiodensity in Hounsfield units (HU) and proton density fat fraction (MRI
PDFF
), respectively. CSA and MFI were highly correlated between CT and MRI (CSA: r = 0.93, P |
doi_str_mv | 10.1038/s41598-020-68797-3 |
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PDFF
), respectively. CSA and MFI were highly correlated between CT and MRI (CSA: r = 0.93, P < 0.001; MFI: r = − 0.90, P < 0.001). Mean CSA was higher in CT compared to MRI (46.6cm
2
versus 43.0cm
2
; P = 0.05) without significance. Based on MRI
PDFF
, a linear regression model was established to directly estimate skeletal muscle fat content from CT. Bland–Altman plots showed a difference between measurements of − 0.5 cm
2
to 7.6 cm
2
and − 4.2% to 2.4% regarding measurements of CSA and MFI, respectively. In conclusion, the provided results indicate interchangeability of CT and MRI derived imaging biomarkers of skeletal muscle quantity and quality. Comparable to MRI
PDFF
, skeletal muscle fat content can be quantified from CT, which might have an impact of analyses in larger cohort studies, particularly in sarcopenia patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-68797-3</identifier><identifier>PMID: 32678260</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53 ; 692/698/1671/1668 ; Adipose Tissue - diagnostic imaging ; Adipose Tissue - pathology ; Adiposity ; Aged ; Body Composition ; Cancer screening ; Computed tomography ; Female ; Humanities and Social Sciences ; Humans ; Magnetic Resonance Imaging ; Male ; Medical screening ; Middle Aged ; multidisciplinary ; Muscle, Skeletal - anatomy & histology ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - pathology ; Muscles ; Musculoskeletal system ; Organ Size ; Sarcopenia ; Science ; Science (multidisciplinary) ; Skeletal muscle ; Tomography, X-Ray Computed</subject><ispartof>Scientific reports, 2020-07, Vol.10 (1), p.11765-11765, Article 11765</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-2d83512595be5b03acc53a616ae31731c8b04035e98671f3bde642c1c0328b243</citedby><cites>FETCH-LOGICAL-c540t-2d83512595be5b03acc53a616ae31731c8b04035e98671f3bde642c1c0328b243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367311/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367311/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32678260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faron, Anton</creatorcontrib><creatorcontrib>Sprinkart, Alois M.</creatorcontrib><creatorcontrib>Kuetting, Daniel L. R.</creatorcontrib><creatorcontrib>Feisst, Andreas</creatorcontrib><creatorcontrib>Isaak, Alexander</creatorcontrib><creatorcontrib>Endler, Christoph</creatorcontrib><creatorcontrib>Chang, Johannes</creatorcontrib><creatorcontrib>Nowak, Sebastian</creatorcontrib><creatorcontrib>Block, Wolfgang</creatorcontrib><creatorcontrib>Thomas, Daniel</creatorcontrib><creatorcontrib>Attenberger, Ulrike</creatorcontrib><creatorcontrib>Luetkens, Julian A.</creatorcontrib><title>Body composition analysis using CT and MRI: intra-individual intermodal comparison of muscle mass and myosteatosis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Computed tomography (CT) and magnetic resonance imaging (MRI) can quantify muscle mass and quality. However, it is still unclear if CT and MRI derived measurements can be used interchangeable. In this prospective study, fifty consecutive participants of a cancer screening program underwent same day low-dose chest CT and MRI. Cross-sectional areas (CSA) of the paraspinal skeletal muscles were obtained. CT and MRI muscle fat infiltration (MFI) were assessed by mean radiodensity in Hounsfield units (HU) and proton density fat fraction (MRI
PDFF
), respectively. CSA and MFI were highly correlated between CT and MRI (CSA: r = 0.93, P < 0.001; MFI: r = − 0.90, P < 0.001). Mean CSA was higher in CT compared to MRI (46.6cm
2
versus 43.0cm
2
; P = 0.05) without significance. Based on MRI
PDFF
, a linear regression model was established to directly estimate skeletal muscle fat content from CT. Bland–Altman plots showed a difference between measurements of − 0.5 cm
2
to 7.6 cm
2
and − 4.2% to 2.4% regarding measurements of CSA and MFI, respectively. In conclusion, the provided results indicate interchangeability of CT and MRI derived imaging biomarkers of skeletal muscle quantity and quality. Comparable to MRI
PDFF
, skeletal muscle fat content can be quantified from CT, which might have an impact of analyses in larger cohort studies, particularly in sarcopenia patients.</description><subject>692/53</subject><subject>692/698/1671/1668</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adipose Tissue - pathology</subject><subject>Adiposity</subject><subject>Aged</subject><subject>Body Composition</subject><subject>Cancer screening</subject><subject>Computed tomography</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical screening</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Muscle, Skeletal - anatomy & histology</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Organ Size</subject><subject>Sarcopenia</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Skeletal muscle</subject><subject>Tomography, X-Ray Computed</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1v1DAQhi1ERau2f4ADisSFS6jtsR2bAxJd8VGpCAmVs-U43sVVEi-epNL-e7xN6dcBXzyaeeadsV9CXjP6nlHQZyiYNLqmnNZKN6ap4QU54lTImgPnLx_Fh-QU8ZqWI7kRzLwih8BVo7miRySfp25X-TRsE8YpprFyo-t3GLGaMY6banVVMl31_efFhyqOU3Z1HLt4E7vZ9ftEyEPqSriXcDliUUjrapjR96EaHOJt-7BLOAU3lSF4Qg7Wrsdwencfk19fPl-tvtWXP75erD5d1l4KOtW80yAZl0a2QbYUnPcSnGLKBWANMK9bKijIYLRq2BraLijBPfMUuG65gGPycdHdzu0QOh_22_d2m-Pg8s4mF-3Tyhh_2026sQ2oos-KwLs7gZz-zAEnO0T0oe_dGNKMlgsujDFM04K-fYZepzmXn1woEFwqXSi-UD4nxBzW98swaveu2sVVW1y1t65aKE1vHj_jvuWfhwWABcBSGjchP8z-j-xfIFuubA</recordid><startdate>20200716</startdate><enddate>20200716</enddate><creator>Faron, Anton</creator><creator>Sprinkart, Alois M.</creator><creator>Kuetting, Daniel L. 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R.</au><au>Feisst, Andreas</au><au>Isaak, Alexander</au><au>Endler, Christoph</au><au>Chang, Johannes</au><au>Nowak, Sebastian</au><au>Block, Wolfgang</au><au>Thomas, Daniel</au><au>Attenberger, Ulrike</au><au>Luetkens, Julian A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body composition analysis using CT and MRI: intra-individual intermodal comparison of muscle mass and myosteatosis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-07-16</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>11765</spage><epage>11765</epage><pages>11765-11765</pages><artnum>11765</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Computed tomography (CT) and magnetic resonance imaging (MRI) can quantify muscle mass and quality. However, it is still unclear if CT and MRI derived measurements can be used interchangeable. In this prospective study, fifty consecutive participants of a cancer screening program underwent same day low-dose chest CT and MRI. Cross-sectional areas (CSA) of the paraspinal skeletal muscles were obtained. CT and MRI muscle fat infiltration (MFI) were assessed by mean radiodensity in Hounsfield units (HU) and proton density fat fraction (MRI
PDFF
), respectively. CSA and MFI were highly correlated between CT and MRI (CSA: r = 0.93, P < 0.001; MFI: r = − 0.90, P < 0.001). Mean CSA was higher in CT compared to MRI (46.6cm
2
versus 43.0cm
2
; P = 0.05) without significance. Based on MRI
PDFF
, a linear regression model was established to directly estimate skeletal muscle fat content from CT. Bland–Altman plots showed a difference between measurements of − 0.5 cm
2
to 7.6 cm
2
and − 4.2% to 2.4% regarding measurements of CSA and MFI, respectively. In conclusion, the provided results indicate interchangeability of CT and MRI derived imaging biomarkers of skeletal muscle quantity and quality. Comparable to MRI
PDFF
, skeletal muscle fat content can be quantified from CT, which might have an impact of analyses in larger cohort studies, particularly in sarcopenia patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32678260</pmid><doi>10.1038/s41598-020-68797-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 692/53 692/698/1671/1668 Adipose Tissue - diagnostic imaging Adipose Tissue - pathology Adiposity Aged Body Composition Cancer screening Computed tomography Female Humanities and Social Sciences Humans Magnetic Resonance Imaging Male Medical screening Middle Aged multidisciplinary Muscle, Skeletal - anatomy & histology Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - pathology Muscles Musculoskeletal system Organ Size Sarcopenia Science Science (multidisciplinary) Skeletal muscle Tomography, X-Ray Computed |
title | Body composition analysis using CT and MRI: intra-individual intermodal comparison of muscle mass and myosteatosis |
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