Disease-associated DNA2 nuclease–helicase protects cells from lethal chromosome under-replication

Abstract DNA2 is an essential nuclease–helicase implicated in DNA repair, lagging-strand DNA synthesis, and the recovery of stalled DNA replication forks (RFs). In Saccharomyces cerevisiae, dna2Δ inviability is reversed by deletion of the conserved helicase PIF1 and/or DNA damage checkpoint-mediator...

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Veröffentlicht in:	Nucleic acids research 2020-07, Vol.48 (13), p.7265-7278
Hauptverfasser:	Falquet, Benoît, Ölmezer, Gizem, Enkner, Franz, Klein, Dominique, Challa, Kiran, Appanah, Rowin, Gasser, Susan M, Rass, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Genome Integrity, Repair and
Online-Zugang:	Volltext
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