NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices

Tissue homeostasis and regeneration rely on resident stem cells (SCs), whose behaviour is regulated through niche-dependent crosstalk. The mechanisms underlying SC identity are still unfolding. Here, using spatiotemporal gene ablation in murine hair follicles, we uncover a critical role for the tran...

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Veröffentlicht in:Nature cell biology 2020-06, Vol.22 (6), p.640-650
Hauptverfasser: Adam, Rene C., Yang, Hanseul, Ge, Yejing, Infarinato, Nicole R., Gur-Cohen, Shiri, Miao, Yuxuan, Wang, Ping, Zhao, Yilin, Lu, Catherine P., Kim, Jeong E., Ko, Joo Y., Paik, Seung S., Gronostajski, Richard M., Kim, Jaehwan, Krueger, James G., Zheng, Deyou, Fuchs, Elaine
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Sprache:eng
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