A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics
The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can...
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| Veröffentlicht in: | Scientific reports 2020-07, Vol.10 (1), p.11833, Article 11833 |
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| creator | Choi, Seung-Min Jeong, Jae-Chan Kim, Jinsun Lim, Eul-Gyoon Kim, Chang-beom Park, Sang-Jin Song, Dae-Yong Krause, Hans-Joachim Hong, Hyobong Kweon, In So |
| description | The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is
20
×
33
×
45
cm
3
in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is
0.13
μ
L
, 10 mg/mL,
1.3
μ
g
(Fe). |
| doi_str_mv | 10.1038/s41598-020-68864-9 |
| format | Article |
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20
×
33
×
45
cm
3
in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is
0.13
μ
L
, 10 mg/mL,
1.3
μ
g
(Fe).</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-68864-9</identifier><identifier>PMID: 32678265</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/166/985 ; 639/166/987 ; 639/925 ; Animals ; Brain - diagnostic imaging ; Humanities and Social Sciences ; Humans ; Image Processing, Computer-Assisted - statistics & numerical data ; Imaging, Three-Dimensional - instrumentation ; Imaging, Three-Dimensional - methods ; Iron oxides ; Laboratories ; Limit of Detection ; Magnetic Iron Oxide Nanoparticles - administration & dosage ; Magnetic Iron Oxide Nanoparticles - chemistry ; Magnetic Phenomena ; Male ; Mice ; Mice, Inbred C57BL ; multidisciplinary ; Nanoparticles ; Point of care testing ; Power consumption ; Radioactive tracers ; Rats ; Rats, Sprague-Dawley ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-07, Vol.10 (1), p.11833, Article 11833</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-e1c49b344440b9f5decdcd0708f8d12637d7f060482261a76a17be3c934ee5a93</citedby><cites>FETCH-LOGICAL-c474t-e1c49b344440b9f5decdcd0708f8d12637d7f060482261a76a17be3c934ee5a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366937/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366937/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32678265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Seung-Min</creatorcontrib><creatorcontrib>Jeong, Jae-Chan</creatorcontrib><creatorcontrib>Kim, Jinsun</creatorcontrib><creatorcontrib>Lim, Eul-Gyoon</creatorcontrib><creatorcontrib>Kim, Chang-beom</creatorcontrib><creatorcontrib>Park, Sang-Jin</creatorcontrib><creatorcontrib>Song, Dae-Yong</creatorcontrib><creatorcontrib>Krause, Hans-Joachim</creatorcontrib><creatorcontrib>Hong, Hyobong</creatorcontrib><creatorcontrib>Kweon, In So</creatorcontrib><title>A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is
20
×
33
×
45
cm
3
in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is
0.13
μ
L
, 10 mg/mL,
1.3
μ
g
(Fe).</description><subject>639/166/985</subject><subject>639/166/987</subject><subject>639/925</subject><subject>Animals</subject><subject>Brain - diagnostic imaging</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - statistics & numerical data</subject><subject>Imaging, Three-Dimensional - instrumentation</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Iron oxides</subject><subject>Laboratories</subject><subject>Limit of Detection</subject><subject>Magnetic Iron Oxide Nanoparticles - administration & dosage</subject><subject>Magnetic Iron Oxide Nanoparticles - chemistry</subject><subject>Magnetic Phenomena</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>multidisciplinary</subject><subject>Nanoparticles</subject><subject>Point of care testing</subject><subject>Power consumption</subject><subject>Radioactive tracers</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rFTEUhgdRbKn9Ay4k4MZNar4mHxuhFLVCwY2uQyY5c5syk1yTucXbX29up9bqwgPhhJznvMnJ23WvKTmjhOv3VdDeaEwYwVJrKbB51h0zInrMOGPPn-yPutNab0iLnhlBzcvuiDOpNJP9cXd3jlK-hQkt1wUAhzhDqjEnN6HZbRIs0aOtKy1NgGI7immD6r4uMKPBVQgop9YLaCzwYwfJ79Ecfx6gMZf7wjbHtOA8Yu8KoBCbaq5Nr77qXoxuqnD6kE-6758-fru4xFdfP3-5OL_CXiixYKBemIGLFmQwYx_ABx-IInrUgTLJVVAjkURoxiR1SjqqBuDecAHQO8NPug-r7nY3zBA8pKW4yW5LG6fsbXbR_l1J8dpu8q1VXErDVRN49yBQcpuxLnaO1cM0uQR5Vy0TTBgjuZYNffsPepN3pf3mSvG2mG4UWylfcq0FxsfHUGIP7trVXdvctffu2sMYb56O8djy28sG8BWorZQ2UP7c_R_ZX6Uosj0</recordid><startdate>20200716</startdate><enddate>20200716</enddate><creator>Choi, Seung-Min</creator><creator>Jeong, Jae-Chan</creator><creator>Kim, Jinsun</creator><creator>Lim, Eul-Gyoon</creator><creator>Kim, Chang-beom</creator><creator>Park, Sang-Jin</creator><creator>Song, Dae-Yong</creator><creator>Krause, Hans-Joachim</creator><creator>Hong, Hyobong</creator><creator>Kweon, In So</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200716</creationdate><title>A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics</title><author>Choi, Seung-Min ; Jeong, Jae-Chan ; Kim, Jinsun ; Lim, Eul-Gyoon ; Kim, Chang-beom ; Park, Sang-Jin ; Song, Dae-Yong ; Krause, Hans-Joachim ; Hong, Hyobong ; Kweon, In So</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-e1c49b344440b9f5decdcd0708f8d12637d7f060482261a76a17be3c934ee5a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>639/166/985</topic><topic>639/166/987</topic><topic>639/925</topic><topic>Animals</topic><topic>Brain - diagnostic imaging</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - statistics & numerical data</topic><topic>Imaging, Three-Dimensional - instrumentation</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Iron oxides</topic><topic>Laboratories</topic><topic>Limit of Detection</topic><topic>Magnetic Iron Oxide Nanoparticles - administration & dosage</topic><topic>Magnetic Iron Oxide Nanoparticles - chemistry</topic><topic>Magnetic Phenomena</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>multidisciplinary</topic><topic>Nanoparticles</topic><topic>Point of care testing</topic><topic>Power consumption</topic><topic>Radioactive tracers</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Seung-Min</creatorcontrib><creatorcontrib>Jeong, Jae-Chan</creatorcontrib><creatorcontrib>Kim, Jinsun</creatorcontrib><creatorcontrib>Lim, Eul-Gyoon</creatorcontrib><creatorcontrib>Kim, Chang-beom</creatorcontrib><creatorcontrib>Park, Sang-Jin</creatorcontrib><creatorcontrib>Song, Dae-Yong</creatorcontrib><creatorcontrib>Krause, Hans-Joachim</creatorcontrib><creatorcontrib>Hong, Hyobong</creatorcontrib><creatorcontrib>Kweon, In So</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Seung-Min</au><au>Jeong, Jae-Chan</au><au>Kim, Jinsun</au><au>Lim, Eul-Gyoon</au><au>Kim, Chang-beom</au><au>Park, Sang-Jin</au><au>Song, Dae-Yong</au><au>Krause, Hans-Joachim</au><au>Hong, Hyobong</au><au>Kweon, In So</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-07-16</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>11833</spage><pages>11833-</pages><artnum>11833</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is
20
×
33
×
45
cm
3
in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is
0.13
μ
L
, 10 mg/mL,
1.3
μ
g
(Fe).</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32678265</pmid><doi>10.1038/s41598-020-68864-9</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 639/166/985 639/166/987 639/925 Animals Brain - diagnostic imaging Humanities and Social Sciences Humans Image Processing, Computer-Assisted - statistics & numerical data Imaging, Three-Dimensional - instrumentation Imaging, Three-Dimensional - methods Iron oxides Laboratories Limit of Detection Magnetic Iron Oxide Nanoparticles - administration & dosage Magnetic Iron Oxide Nanoparticles - chemistry Magnetic Phenomena Male Mice Mice, Inbred C57BL multidisciplinary Nanoparticles Point of care testing Power consumption Radioactive tracers Rats Rats, Sprague-Dawley Science Science (multidisciplinary) |
| title | A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics |
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