Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways

BACKGROUND The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with all reproductive and metabolic phenotypes in a rat model. MATERIAL AND METHODS Twenty-four 3-week-old female Sprague-Dawley rats were ra...

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Veröffentlicht in:	Medical science monitor 2020-07, Vol.26, p.e923073-e923073-13
Hauptverfasser:	Xu, Jinbang, Dun, Jingjing, Yang, Juan, Zhang, Junxin, Lin, Qiuping, Huang, Mingqing, Ji, Feng, Huang, Lishan, You, Xiumi, Lin, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Study Animals Body Weight Diet, High-Fat - adverse effects Disease Models, Animal Estrous Cycle - drug effects Female Insulin - metabolism Insulin Resistance - physiology Letrozole - adverse effects Letrozole - pharmacology Lipid Metabolism - drug effects Lipids - physiology Obesity - metabolism Ovary - metabolism Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - physiopathology Rats Rats, Sprague-Dawley Signal Transduction - physiology
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