MOSPD2 is a therapeutic target for the treatment of CNS inflammation

Summary In multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), myeloid cells comprise a major part of the inflammatory infiltrate in the central nervous system (CNS). We previously described that motile sperm domain‐containing protein 2 (MOSPD2) is expressed on human myeloid cell...

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Veröffentlicht in:	Clinical and experimental immunology 2020-08, Vol.201 (2), p.105-120
Hauptverfasser:	Yacov, N., Kafri, P., Salem, Y., Propheta‐Meiran, O., Feldman, B., Breitbart, E., Mendel, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement Cells, Cultured Central nervous system Central Nervous System - immunology Disease Models, Animal EAE Editors' Choice Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - therapy Experimental allergic encephalomyelitis Female Humans Inflammation - genetics Inflammation - metabolism Inflammation - therapy Inflammatory diseases Interleukin-4 - metabolism Leukocyte migration Lymphocytes T Lymphoid tissue Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout migration Monoclonal antibodies Monocytes Monocytes - immunology MOSPD2 Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - metabolism Multiple Sclerosis - therapy Myeloid Myeloid cells Original Receptors, Chemokine - genetics Receptors, Chemokine - metabolism T-Lymphocytes - immunology Th1-Th2 Balance Therapeutic applications
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