Early neutrophil count relates to infarct size and fatal outcome after large hemispheric infarction
Aims To investigate the relationship between peripheral leukocyte dynamics and the outcome of large hemispheric infarction (LHI) patients. Methods Patients with acute LHI admitted to the neuro‐intensive care unit of Xuanwu Hospital from 2013 to 2017 were prospectively enrolled and followed up for 6 ...
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| Veröffentlicht in: | CNS neuroscience & therapeutics 2020-08, Vol.26 (8), p.829-836 |
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| creator | Cui, Li‐li Zhang, Yan Chen, Zhong‐yun Su, Ying‐ying Liu, Yawu Boltze, Johannes |
| description | Aims
To investigate the relationship between peripheral leukocyte dynamics and the outcome of large hemispheric infarction (LHI) patients.
Methods
Patients with acute LHI admitted to the neuro‐intensive care unit of Xuanwu Hospital from 2013 to 2017 were prospectively enrolled and followed up for 6 months after LHI.
Results
A total of 84 LHI patients were included, 38 patients suffered brain herniation and 20 patients died from stroke. Compared to patients with benign course, LHI patients with fatal outcome showed larger infarcts and more severe brain edema (P |
| doi_str_mv | 10.1111/cns.13381 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7366744</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2399250198</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4431-701de899766243e45503cbf58bbea55d9ecdf3d85251ea2a6925e31e55c879623</originalsourceid><addsrcrecordid>eNp1kUFPGzEQha2KqoTQA38AWeJSDglre-1dX5BQFKASag-lZ8vxzhIjxw62lyr8-rpNiFokfBnL_ubNGz2ETkg1JeVcGJ-mhLGWfEAj0nA-4bKWB_s7qw7RUUqPVSVoK9tP6JBR1tSckhEycx3dBnsYcgzrpXXYhMFnHMHpDAnngK3vdTQZJ_sCWPsO9zprh8OQTViVlz5DxE7HB8BLWNm0XkK05rXNBn-MPvbaJfi8q2P083p-P7ud3H2_-Tq7upuYumZk0lSkg1bKRghaM6g5r5hZ9LxdLEBz3kkwXc-6llNOQFMtJOXACHBu2kYKysbocqu7HhYr6Az4HLVT62hXOm5U0Fb9_-PtUj2EZ9UwIZriYYy-7ARieBogZVXWMeCc9hCGpCiTZWZFZFvQszfoYxiiL-spWhf7gtRCFOp8S5kYUorQ782QSv2JTpXo1N_oCnv6r_s9-ZpVAS62wC_rYPO-kpp9-7GV_A3p6KRl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2424361466</pqid></control><display><type>article</type><title>Early neutrophil count relates to infarct size and fatal outcome after large hemispheric infarction</title><source>Wiley-Blackwell Journals</source><source>Directory of Open Access Journals</source><source>NCBI_PubMed Central（免费）</source><source>Wiley_OA刊</source><source>Free E-Journal (出版社公開部分のみ）</source><creator>Cui, Li‐li ; Zhang, Yan ; Chen, Zhong‐yun ; Su, Ying‐ying ; Liu, Yawu ; Boltze, Johannes</creator><creatorcontrib>Cui, Li‐li ; Zhang, Yan ; Chen, Zhong‐yun ; Su, Ying‐ying ; Liu, Yawu ; Boltze, Johannes</creatorcontrib><description>Aims
To investigate the relationship between peripheral leukocyte dynamics and the outcome of large hemispheric infarction (LHI) patients.
Methods
Patients with acute LHI admitted to the neuro‐intensive care unit of Xuanwu Hospital from 2013 to 2017 were prospectively enrolled and followed up for 6 months after LHI.
Results
A total of 84 LHI patients were included, 38 patients suffered brain herniation and 20 patients died from stroke. Compared to patients with benign course, LHI patients with fatal outcome showed larger infarcts and more severe brain edema (P < .01), as well as increased WBC and neutrophil counts throughout the first week after stroke (P < .05). Correlation analysis revealed that neutrophil counts on D2 after LHI positively correlated with infarct and edema volumes measured from CT/MRI (R2 = 0.22 and R2 = 0.15, P < .01) and negatively correlated with Glasgow Coma Scale (ρ = −0.234, P < .05). Patients with D2 neutrophils > 7.14 × 109/L had higher risk of brain herniation [odds ratio (OR) = 7.5, 95% CI: 2.0‐28.1, P = .001], and patients with D2 neutrophils > 7.79 × 109/L had a higher risk of death (OR = 5.8, 95% CI: 1.2‐27.0, P = .015).
Conclusion
Early peripheral neutrophil count after stroke relates to infarct size and the fatal outcome of LHI patients, which might help guiding acute LHI management such as reduction of intracranial pressure and potential antiinflammatory therapy in the future.</description><identifier>ISSN: 1755-5930</identifier><identifier>EISSN: 1755-5949</identifier><identifier>DOI: 10.1111/cns.13381</identifier><identifier>PMID: 32374521</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Age ; Alcohol ; Atherosclerosis ; Blood ; Body temperature ; brain edema ; Cardiac arrhythmia ; Cardiovascular disease ; Cerebral infarction ; Coma ; Consciousness ; Correlation analysis ; Diabetes ; Edema ; Embolisms ; Family medical history ; Females ; Heart failure ; Hemorrhage ; Hypertension ; large hemispheric infarction ; Leukocytes (neutrophilic) ; Magnetic resonance imaging ; Mortality ; neutrophil ; Neutrophils ; Original ; outcome ; Patients ; Stroke ; Veins & arteries ; Ventilators</subject><ispartof>CNS neuroscience & therapeutics, 2020-08, Vol.26 (8), p.829-836</ispartof><rights>2020 The Authors. Published by John Wiley & Sons Ltd.</rights><rights>2020 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4431-701de899766243e45503cbf58bbea55d9ecdf3d85251ea2a6925e31e55c879623</citedby><cites>FETCH-LOGICAL-c4431-701de899766243e45503cbf58bbea55d9ecdf3d85251ea2a6925e31e55c879623</cites><orcidid>0000-0002-6931-7263</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366744/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366744/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32374521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Li‐li</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Chen, Zhong‐yun</creatorcontrib><creatorcontrib>Su, Ying‐ying</creatorcontrib><creatorcontrib>Liu, Yawu</creatorcontrib><creatorcontrib>Boltze, Johannes</creatorcontrib><title>Early neutrophil count relates to infarct size and fatal outcome after large hemispheric infarction</title><title>CNS neuroscience & therapeutics</title><addtitle>CNS Neurosci Ther</addtitle><description>Aims
To investigate the relationship between peripheral leukocyte dynamics and the outcome of large hemispheric infarction (LHI) patients.
Methods
Patients with acute LHI admitted to the neuro‐intensive care unit of Xuanwu Hospital from 2013 to 2017 were prospectively enrolled and followed up for 6 months after LHI.
Results
A total of 84 LHI patients were included, 38 patients suffered brain herniation and 20 patients died from stroke. Compared to patients with benign course, LHI patients with fatal outcome showed larger infarcts and more severe brain edema (P < .01), as well as increased WBC and neutrophil counts throughout the first week after stroke (P < .05). Correlation analysis revealed that neutrophil counts on D2 after LHI positively correlated with infarct and edema volumes measured from CT/MRI (R2 = 0.22 and R2 = 0.15, P < .01) and negatively correlated with Glasgow Coma Scale (ρ = −0.234, P < .05). Patients with D2 neutrophils > 7.14 × 109/L had higher risk of brain herniation [odds ratio (OR) = 7.5, 95% CI: 2.0‐28.1, P = .001], and patients with D2 neutrophils > 7.79 × 109/L had a higher risk of death (OR = 5.8, 95% CI: 1.2‐27.0, P = .015).
Conclusion
Early peripheral neutrophil count after stroke relates to infarct size and the fatal outcome of LHI patients, which might help guiding acute LHI management such as reduction of intracranial pressure and potential antiinflammatory therapy in the future.</description><subject>Age</subject><subject>Alcohol</subject><subject>Atherosclerosis</subject><subject>Blood</subject><subject>Body temperature</subject><subject>brain edema</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Cerebral infarction</subject><subject>Coma</subject><subject>Consciousness</subject><subject>Correlation analysis</subject><subject>Diabetes</subject><subject>Edema</subject><subject>Embolisms</subject><subject>Family medical history</subject><subject>Females</subject><subject>Heart failure</subject><subject>Hemorrhage</subject><subject>Hypertension</subject><subject>large hemispheric infarction</subject><subject>Leukocytes (neutrophilic)</subject><subject>Magnetic resonance imaging</subject><subject>Mortality</subject><subject>neutrophil</subject><subject>Neutrophils</subject><subject>Original</subject><subject>outcome</subject><subject>Patients</subject><subject>Stroke</subject><subject>Veins & arteries</subject><subject>Ventilators</subject><issn>1755-5930</issn><issn>1755-5949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFPGzEQha2KqoTQA38AWeJSDglre-1dX5BQFKASag-lZ8vxzhIjxw62lyr8-rpNiFokfBnL_ubNGz2ETkg1JeVcGJ-mhLGWfEAj0nA-4bKWB_s7qw7RUUqPVSVoK9tP6JBR1tSckhEycx3dBnsYcgzrpXXYhMFnHMHpDAnngK3vdTQZJ_sCWPsO9zprh8OQTViVlz5DxE7HB8BLWNm0XkK05rXNBn-MPvbaJfi8q2P083p-P7ud3H2_-Tq7upuYumZk0lSkg1bKRghaM6g5r5hZ9LxdLEBz3kkwXc-6llNOQFMtJOXACHBu2kYKysbocqu7HhYr6Az4HLVT62hXOm5U0Fb9_-PtUj2EZ9UwIZriYYy-7ARieBogZVXWMeCc9hCGpCiTZWZFZFvQszfoYxiiL-spWhf7gtRCFOp8S5kYUorQ782QSv2JTpXo1N_oCnv6r_s9-ZpVAS62wC_rYPO-kpp9-7GV_A3p6KRl</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Cui, Li‐li</creator><creator>Zhang, Yan</creator><creator>Chen, Zhong‐yun</creator><creator>Su, Ying‐ying</creator><creator>Liu, Yawu</creator><creator>Boltze, Johannes</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6931-7263</orcidid></search><sort><creationdate>202008</creationdate><title>Early neutrophil count relates to infarct size and fatal outcome after large hemispheric infarction</title><author>Cui, Li‐li ; Zhang, Yan ; Chen, Zhong‐yun ; Su, Ying‐ying ; Liu, Yawu ; Boltze, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4431-701de899766243e45503cbf58bbea55d9ecdf3d85251ea2a6925e31e55c879623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Alcohol</topic><topic>Atherosclerosis</topic><topic>Blood</topic><topic>Body temperature</topic><topic>brain edema</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Cerebral infarction</topic><topic>Coma</topic><topic>Consciousness</topic><topic>Correlation analysis</topic><topic>Diabetes</topic><topic>Edema</topic><topic>Embolisms</topic><topic>Family medical history</topic><topic>Females</topic><topic>Heart failure</topic><topic>Hemorrhage</topic><topic>Hypertension</topic><topic>large hemispheric infarction</topic><topic>Leukocytes (neutrophilic)</topic><topic>Magnetic resonance imaging</topic><topic>Mortality</topic><topic>neutrophil</topic><topic>Neutrophils</topic><topic>Original</topic><topic>outcome</topic><topic>Patients</topic><topic>Stroke</topic><topic>Veins & arteries</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Li‐li</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Chen, Zhong‐yun</creatorcontrib><creatorcontrib>Su, Ying‐ying</creatorcontrib><creatorcontrib>Liu, Yawu</creatorcontrib><creatorcontrib>Boltze, Johannes</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley-Blackwell Open Access Backfiles</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>CNS neuroscience & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Li‐li</au><au>Zhang, Yan</au><au>Chen, Zhong‐yun</au><au>Su, Ying‐ying</au><au>Liu, Yawu</au><au>Boltze, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early neutrophil count relates to infarct size and fatal outcome after large hemispheric infarction</atitle><jtitle>CNS neuroscience & therapeutics</jtitle><addtitle>CNS Neurosci Ther</addtitle><date>2020-08</date><risdate>2020</risdate><volume>26</volume><issue>8</issue><spage>829</spage><epage>836</epage><pages>829-836</pages><issn>1755-5930</issn><eissn>1755-5949</eissn><abstract>Aims
To investigate the relationship between peripheral leukocyte dynamics and the outcome of large hemispheric infarction (LHI) patients.
Methods
Patients with acute LHI admitted to the neuro‐intensive care unit of Xuanwu Hospital from 2013 to 2017 were prospectively enrolled and followed up for 6 months after LHI.
Results
A total of 84 LHI patients were included, 38 patients suffered brain herniation and 20 patients died from stroke. Compared to patients with benign course, LHI patients with fatal outcome showed larger infarcts and more severe brain edema (P < .01), as well as increased WBC and neutrophil counts throughout the first week after stroke (P < .05). Correlation analysis revealed that neutrophil counts on D2 after LHI positively correlated with infarct and edema volumes measured from CT/MRI (R2 = 0.22 and R2 = 0.15, P < .01) and negatively correlated with Glasgow Coma Scale (ρ = −0.234, P < .05). Patients with D2 neutrophils > 7.14 × 109/L had higher risk of brain herniation [odds ratio (OR) = 7.5, 95% CI: 2.0‐28.1, P = .001], and patients with D2 neutrophils > 7.79 × 109/L had a higher risk of death (OR = 5.8, 95% CI: 1.2‐27.0, P = .015).
Conclusion
Early peripheral neutrophil count after stroke relates to infarct size and the fatal outcome of LHI patients, which might help guiding acute LHI management such as reduction of intracranial pressure and potential antiinflammatory therapy in the future.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>32374521</pmid><doi>10.1111/cns.13381</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6931-7263</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Alcohol Atherosclerosis Blood Body temperature brain edema Cardiac arrhythmia Cardiovascular disease Cerebral infarction Coma Consciousness Correlation analysis Diabetes Edema Embolisms Family medical history Females Heart failure Hemorrhage Hypertension large hemispheric infarction Leukocytes (neutrophilic) Magnetic resonance imaging Mortality neutrophil Neutrophils Original outcome Patients Stroke Veins & arteries Ventilators |
| title | Early neutrophil count relates to infarct size and fatal outcome after large hemispheric infarction |
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