Validation of genome-wide associated variants for Kawasaki disease in a Taiwanese case–control sample
Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that affects infants and young children. Considerable evidence supports the hypothesis that there is a genetic basis for KD susceptibility. Genome-wide association studies (GWAS) have identified several genetic variant...
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| creator | Chen, Ming-Ren Chang, Tzu-Yang Chiu, Nan-Chang Chi, Hsin Yang, Kuender D. Chang, Lung Huang, Daniel Tsung-Ning Huang, Fu-Yuan Lien, Ya-Ping Lin, Wen-Shan Lin, Chiung-Ling Chang, Luan-Yin Lee, Yann-Jinn |
| description | Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that affects infants and young children. Considerable evidence supports the hypothesis that there is a genetic basis for KD susceptibility. Genome-wide association studies (GWAS) have identified several genetic variants associated with KD. This study aims to replicate three novel KD-associated single nucleotide polymorphisms (SNPs), identified by GWAS in Japanese, in a Taiwanese population. Associations between these SNPs and development of coronary artery lesions (CALs) were also investigated. The
rs2254546 A/G
,
rs2857151 A/G
, and
rs4813003 C/T
SNPs were genotyped in 681 children with KD and 563 ethnically-matched healthy controls using TaqMan Assay or DNA sequencing. We found
rs2254546
and
rs4813003
SNPs were significantly associated with KD (
G
allele, odds ratio [OR] = 1.54,
P
= 1.0 × 10
–5
;
C
allele, OR = 1.32,
P
= 8.1 × 10
–4
). However, no evidence for associations with CAL development was observed. Our study successfully validates associations of the
rs2254546
and
rs4813003
SNPs with KD in a Taiwanese population. Further functional studies of the SNPs are important in understanding the pathogenesis of KD. |
| doi_str_mv | 10.1038/s41598-020-68673-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7366615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2424342141</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-84aedb9cfd56d5e21e1311c24d408e4c32a82f9d3a39947ec1022019be436c2b3</originalsourceid><addsrcrecordid>eNp9kU1uFDEQhVsIRKKQC7BAltiwabDL7h57g4QiCIhIbBK2Vo1dPTh024PdkxE77pAbchJMJn-wiDf-qa-e6-k1zXPBXwsu9ZuiRGd0y4G3ve4XsuWPmn3gqmtBAjy-d95rDks553V1YJQwT5s9Cf1CA9f7zeorjsHjHFJkaWArimmidhs8MSwluYAzeXaBOWCcCxtSZp9xiwW_B-ZDISzEQmTITjFsMVK9uvr2-9elS3HOaWQFp_VIz5onA46FDq_3g-bsw_vTo4_tyZfjT0fvTlrXKT63WiH5pXGD73rfEQgSUggHyiuuSTkJqGEwXqI0Ri3ICQ7AhVmSkr2DpTxo3u5015vlRN5RHQJHu85hwvzTJgz230oM3-wqXdiF7PtedFXg1bVATj82VGY7heJoHKu5tCkWFChjQGqo6Mv_0PO0ybHau6KkAqFEpWBHuZxKyTTcDiO4_Rul3UVpa5T2KkrLa9OL-zZuW26Cq4DcAaWW4ory3d8PyP4BpeGrsA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2424342141</pqid></control><display><type>article</type><title>Validation of genome-wide associated variants for Kawasaki disease in a Taiwanese case–control sample</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Chen, Ming-Ren ; Chang, Tzu-Yang ; Chiu, Nan-Chang ; Chi, Hsin ; Yang, Kuender D. ; Chang, Lung ; Huang, Daniel Tsung-Ning ; Huang, Fu-Yuan ; Lien, Ya-Ping ; Lin, Wen-Shan ; Lin, Chiung-Ling ; Chang, Luan-Yin ; Lee, Yann-Jinn</creator><creatorcontrib>Chen, Ming-Ren ; Chang, Tzu-Yang ; Chiu, Nan-Chang ; Chi, Hsin ; Yang, Kuender D. ; Chang, Lung ; Huang, Daniel Tsung-Ning ; Huang, Fu-Yuan ; Lien, Ya-Ping ; Lin, Wen-Shan ; Lin, Chiung-Ling ; Chang, Luan-Yin ; Lee, Yann-Jinn</creatorcontrib><description>Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that affects infants and young children. Considerable evidence supports the hypothesis that there is a genetic basis for KD susceptibility. Genome-wide association studies (GWAS) have identified several genetic variants associated with KD. This study aims to replicate three novel KD-associated single nucleotide polymorphisms (SNPs), identified by GWAS in Japanese, in a Taiwanese population. Associations between these SNPs and development of coronary artery lesions (CALs) were also investigated. The
rs2254546 A/G
,
rs2857151 A/G
, and
rs4813003 C/T
SNPs were genotyped in 681 children with KD and 563 ethnically-matched healthy controls using TaqMan Assay or DNA sequencing. We found
rs2254546
and
rs4813003
SNPs were significantly associated with KD (
G
allele, odds ratio [OR] = 1.54,
P
= 1.0 × 10
–5
;
C
allele, OR = 1.32,
P
= 8.1 × 10
–4
). However, no evidence for associations with CAL development was observed. Our study successfully validates associations of the
rs2254546
and
rs4813003
SNPs with KD in a Taiwanese population. Further functional studies of the SNPs are important in understanding the pathogenesis of KD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-68673-0</identifier><identifier>PMID: 32678208</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208 ; 631/250 ; 692/308 ; 692/4017 ; 692/420 ; 692/499 ; 692/53 ; 692/699 ; Adolescent ; Adult ; Aged ; Alleles ; Asian Continental Ancestry Group - genetics ; Case-Control Studies ; Child ; Child, Preschool ; Children ; Coronary artery ; DNA sequencing ; Etiology ; Female ; Gene Frequency ; Genetic diversity ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Genotype ; Humanities and Social Sciences ; Humans ; Infant ; Infants ; Kawasaki disease ; Male ; Middle Aged ; Mucocutaneous lymph node syndrome ; Mucocutaneous Lymph Node Syndrome - genetics ; multidisciplinary ; Odds Ratio ; Polymorphism, Single Nucleotide ; Population studies ; Science ; Science (multidisciplinary) ; Single-nucleotide polymorphism ; Systemic vasculitis ; Taiwan ; Young Adult</subject><ispartof>Scientific reports, 2020-07, Vol.10 (1), p.11756-11756, Article 11756</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-84aedb9cfd56d5e21e1311c24d408e4c32a82f9d3a39947ec1022019be436c2b3</citedby><cites>FETCH-LOGICAL-c540t-84aedb9cfd56d5e21e1311c24d408e4c32a82f9d3a39947ec1022019be436c2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366615/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366615/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51555,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32678208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ming-Ren</creatorcontrib><creatorcontrib>Chang, Tzu-Yang</creatorcontrib><creatorcontrib>Chiu, Nan-Chang</creatorcontrib><creatorcontrib>Chi, Hsin</creatorcontrib><creatorcontrib>Yang, Kuender D.</creatorcontrib><creatorcontrib>Chang, Lung</creatorcontrib><creatorcontrib>Huang, Daniel Tsung-Ning</creatorcontrib><creatorcontrib>Huang, Fu-Yuan</creatorcontrib><creatorcontrib>Lien, Ya-Ping</creatorcontrib><creatorcontrib>Lin, Wen-Shan</creatorcontrib><creatorcontrib>Lin, Chiung-Ling</creatorcontrib><creatorcontrib>Chang, Luan-Yin</creatorcontrib><creatorcontrib>Lee, Yann-Jinn</creatorcontrib><title>Validation of genome-wide associated variants for Kawasaki disease in a Taiwanese case–control sample</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that affects infants and young children. Considerable evidence supports the hypothesis that there is a genetic basis for KD susceptibility. Genome-wide association studies (GWAS) have identified several genetic variants associated with KD. This study aims to replicate three novel KD-associated single nucleotide polymorphisms (SNPs), identified by GWAS in Japanese, in a Taiwanese population. Associations between these SNPs and development of coronary artery lesions (CALs) were also investigated. The
rs2254546 A/G
,
rs2857151 A/G
, and
rs4813003 C/T
SNPs were genotyped in 681 children with KD and 563 ethnically-matched healthy controls using TaqMan Assay or DNA sequencing. We found
rs2254546
and
rs4813003
SNPs were significantly associated with KD (
G
allele, odds ratio [OR] = 1.54,
P
= 1.0 × 10
–5
;
C
allele, OR = 1.32,
P
= 8.1 × 10
–4
). However, no evidence for associations with CAL development was observed. Our study successfully validates associations of the
rs2254546
and
rs4813003
SNPs with KD in a Taiwanese population. Further functional studies of the SNPs are important in understanding the pathogenesis of KD.</description><subject>631/208</subject><subject>631/250</subject><subject>692/308</subject><subject>692/4017</subject><subject>692/420</subject><subject>692/499</subject><subject>692/53</subject><subject>692/699</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Coronary artery</subject><subject>DNA sequencing</subject><subject>Etiology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Kawasaki disease</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucocutaneous lymph node syndrome</subject><subject>Mucocutaneous Lymph Node Syndrome - genetics</subject><subject>multidisciplinary</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Single-nucleotide polymorphism</subject><subject>Systemic vasculitis</subject><subject>Taiwan</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1uFDEQhVsIRKKQC7BAltiwabDL7h57g4QiCIhIbBK2Vo1dPTh024PdkxE77pAbchJMJn-wiDf-qa-e6-k1zXPBXwsu9ZuiRGd0y4G3ve4XsuWPmn3gqmtBAjy-d95rDks553V1YJQwT5s9Cf1CA9f7zeorjsHjHFJkaWArimmidhs8MSwluYAzeXaBOWCcCxtSZp9xiwW_B-ZDISzEQmTITjFsMVK9uvr2-9elS3HOaWQFp_VIz5onA46FDq_3g-bsw_vTo4_tyZfjT0fvTlrXKT63WiH5pXGD73rfEQgSUggHyiuuSTkJqGEwXqI0Ri3ICQ7AhVmSkr2DpTxo3u5015vlRN5RHQJHu85hwvzTJgz230oM3-wqXdiF7PtedFXg1bVATj82VGY7heJoHKu5tCkWFChjQGqo6Mv_0PO0ybHau6KkAqFEpWBHuZxKyTTcDiO4_Rul3UVpa5T2KkrLa9OL-zZuW26Cq4DcAaWW4ory3d8PyP4BpeGrsA</recordid><startdate>20200716</startdate><enddate>20200716</enddate><creator>Chen, Ming-Ren</creator><creator>Chang, Tzu-Yang</creator><creator>Chiu, Nan-Chang</creator><creator>Chi, Hsin</creator><creator>Yang, Kuender D.</creator><creator>Chang, Lung</creator><creator>Huang, Daniel Tsung-Ning</creator><creator>Huang, Fu-Yuan</creator><creator>Lien, Ya-Ping</creator><creator>Lin, Wen-Shan</creator><creator>Lin, Chiung-Ling</creator><creator>Chang, Luan-Yin</creator><creator>Lee, Yann-Jinn</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200716</creationdate><title>Validation of genome-wide associated variants for Kawasaki disease in a Taiwanese case–control sample</title><author>Chen, Ming-Ren ; Chang, Tzu-Yang ; Chiu, Nan-Chang ; Chi, Hsin ; Yang, Kuender D. ; Chang, Lung ; Huang, Daniel Tsung-Ning ; Huang, Fu-Yuan ; Lien, Ya-Ping ; Lin, Wen-Shan ; Lin, Chiung-Ling ; Chang, Luan-Yin ; Lee, Yann-Jinn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-84aedb9cfd56d5e21e1311c24d408e4c32a82f9d3a39947ec1022019be436c2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/208</topic><topic>631/250</topic><topic>692/308</topic><topic>692/4017</topic><topic>692/420</topic><topic>692/499</topic><topic>692/53</topic><topic>692/699</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Coronary artery</topic><topic>DNA sequencing</topic><topic>Etiology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Genome-wide association studies</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Kawasaki disease</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucocutaneous lymph node syndrome</topic><topic>Mucocutaneous Lymph Node Syndrome - genetics</topic><topic>multidisciplinary</topic><topic>Odds Ratio</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Single-nucleotide polymorphism</topic><topic>Systemic vasculitis</topic><topic>Taiwan</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ming-Ren</creatorcontrib><creatorcontrib>Chang, Tzu-Yang</creatorcontrib><creatorcontrib>Chiu, Nan-Chang</creatorcontrib><creatorcontrib>Chi, Hsin</creatorcontrib><creatorcontrib>Yang, Kuender D.</creatorcontrib><creatorcontrib>Chang, Lung</creatorcontrib><creatorcontrib>Huang, Daniel Tsung-Ning</creatorcontrib><creatorcontrib>Huang, Fu-Yuan</creatorcontrib><creatorcontrib>Lien, Ya-Ping</creatorcontrib><creatorcontrib>Lin, Wen-Shan</creatorcontrib><creatorcontrib>Lin, Chiung-Ling</creatorcontrib><creatorcontrib>Chang, Luan-Yin</creatorcontrib><creatorcontrib>Lee, Yann-Jinn</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ming-Ren</au><au>Chang, Tzu-Yang</au><au>Chiu, Nan-Chang</au><au>Chi, Hsin</au><au>Yang, Kuender D.</au><au>Chang, Lung</au><au>Huang, Daniel Tsung-Ning</au><au>Huang, Fu-Yuan</au><au>Lien, Ya-Ping</au><au>Lin, Wen-Shan</au><au>Lin, Chiung-Ling</au><au>Chang, Luan-Yin</au><au>Lee, Yann-Jinn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of genome-wide associated variants for Kawasaki disease in a Taiwanese case–control sample</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-07-16</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>11756</spage><epage>11756</epage><pages>11756-11756</pages><artnum>11756</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that affects infants and young children. Considerable evidence supports the hypothesis that there is a genetic basis for KD susceptibility. Genome-wide association studies (GWAS) have identified several genetic variants associated with KD. This study aims to replicate three novel KD-associated single nucleotide polymorphisms (SNPs), identified by GWAS in Japanese, in a Taiwanese population. Associations between these SNPs and development of coronary artery lesions (CALs) were also investigated. The
rs2254546 A/G
,
rs2857151 A/G
, and
rs4813003 C/T
SNPs were genotyped in 681 children with KD and 563 ethnically-matched healthy controls using TaqMan Assay or DNA sequencing. We found
rs2254546
and
rs4813003
SNPs were significantly associated with KD (
G
allele, odds ratio [OR] = 1.54,
P
= 1.0 × 10
–5
;
C
allele, OR = 1.32,
P
= 8.1 × 10
–4
). However, no evidence for associations with CAL development was observed. Our study successfully validates associations of the
rs2254546
and
rs4813003
SNPs with KD in a Taiwanese population. Further functional studies of the SNPs are important in understanding the pathogenesis of KD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32678208</pmid><doi>10.1038/s41598-020-68673-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Nature Free; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 631/208 631/250 692/308 692/4017 692/420 692/499 692/53 692/699 Adolescent Adult Aged Alleles Asian Continental Ancestry Group - genetics Case-Control Studies Child Child, Preschool Children Coronary artery DNA sequencing Etiology Female Gene Frequency Genetic diversity Genetic Predisposition to Disease Genetic Variation Genome-wide association studies Genome-Wide Association Study Genomes Genotype Humanities and Social Sciences Humans Infant Infants Kawasaki disease Male Middle Aged Mucocutaneous lymph node syndrome Mucocutaneous Lymph Node Syndrome - genetics multidisciplinary Odds Ratio Polymorphism, Single Nucleotide Population studies Science Science (multidisciplinary) Single-nucleotide polymorphism Systemic vasculitis Taiwan Young Adult |
| title | Validation of genome-wide associated variants for Kawasaki disease in a Taiwanese case–control sample |
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