Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela
This study represents the first report on the distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all KIR genes are present in this population. Frequency of inhibitory killer cell immunoglobulin‐like receptors (KIRs) exceeded 0.69, excep...
Gespeichert in:
| Veröffentlicht in: | Tissue antigens 2010-06, Vol.75 (6), p.724-729 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 729 |
|---|---|
| container_issue | 6 |
| container_start_page | 724 |
| container_title | Tissue antigens |
| container_volume | 75 |
| creator | Conesa, A. Fernández-Mestre, M. Padrón, D. Toro, F. Silva, N. Tassinari, P. Blanca, I. Martin, M.P. Carrington, M. Layrisse, Z. |
| description | This study represents the first report on the distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all KIR genes are present in this population. Frequency of inhibitory killer cell immunoglobulin‐like receptors (KIRs) exceeded 0.69, except for KIR2DL2 (0.29) and 2DL5 (0.37). Activating KIRs showed low frequencies (0.11–0.29), except for KIR2DS4 (0.68). Forty‐five different KIR genotypes were identified, with a predominance of three genotypes found in 50.7% of the population of which 25.9% were individuals homozygous for haplotype A. The frequencies of KIR genes reflect the ethnic admixture existing in the mestizo Venezuelan population. |
| doi_str_mv | 10.1111/j.1399-0039.2010.01446.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7366394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>745635826</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5436-f67bc22a9a2c6d6bd62604d2ee687f0bbabdc319755fe8b3278582268684b4903</originalsourceid><addsrcrecordid>eNqNkk1v0zAcxi0EYmXwFZBvnFL8Fjs-gDQNuiFVQ5MGHC07cTq3ThzsBLp9epx1VHACX_z2ex7778cAQIyWOLe32yWmUhYIUbkkKK8izBhf7p-AxXHjKVgghHBBKlyegBcpbfOMCSmfgxOCCEYSVwuw-eDSGJ2ZRhd6GFq4c97bCGvrPXRdN_Vh44OZvOsL73YWRlvbYQwRbmxvE3Q9HG8t7Gwa3X2AQxgmrx-82hg6-DVD95P1-iV41mqf7KvH_hR8WX28Ob8s1p8vPp2frYu6ZJQXLRemJkRLTWrecNNwwhFriLW8Ei0yRpumpliKsmxtZSgRVVkRwiteMcMkoqfg_cF3mExnm9r2Y9ReDdF1Ot6poJ36e6d3t2oTfihBOaeSZYM3jwYxfJ9yWapzaX4N3dswJSVYyWk-k_-bpJQiXGKSyepA1jGkFG17vA9Gag5UbdWcm5pzU3Og6iFQtc_S13_WcxT-TjAD7w7AT-ft3X8bq5uzq3mU9cVBn_-B3R_1Ou4UF1SU6tvVhbq-XK2uqVgrRn8BXYfApQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733301512</pqid></control><display><type>article</type><title>Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Conesa, A. ; Fernández-Mestre, M. ; Padrón, D. ; Toro, F. ; Silva, N. ; Tassinari, P. ; Blanca, I. ; Martin, M.P. ; Carrington, M. ; Layrisse, Z.</creator><creatorcontrib>Conesa, A. ; Fernández-Mestre, M. ; Padrón, D. ; Toro, F. ; Silva, N. ; Tassinari, P. ; Blanca, I. ; Martin, M.P. ; Carrington, M. ; Layrisse, Z.</creatorcontrib><description>This study represents the first report on the distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all KIR genes are present in this population. Frequency of inhibitory killer cell immunoglobulin‐like receptors (KIRs) exceeded 0.69, except for KIR2DL2 (0.29) and 2DL5 (0.37). Activating KIRs showed low frequencies (0.11–0.29), except for KIR2DS4 (0.68). Forty‐five different KIR genotypes were identified, with a predominance of three genotypes found in 50.7% of the population of which 25.9% were individuals homozygous for haplotype A. The frequencies of KIR genes reflect the ethnic admixture existing in the mestizo Venezuelan population.</description><identifier>ISSN: 0001-2815</identifier><identifier>ISSN: 1399-0039</identifier><identifier>EISSN: 1399-0039</identifier><identifier>DOI: 10.1111/j.1399-0039.2010.01446.x</identifier><identifier>PMID: 20210918</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Gene Frequency ; Humans ; KIR ; mestizo Venezuelan population ; natural killer cells ; Phylogeny ; polymerase chain reaction-sequence-specific primers ; Population - genetics ; Receptors, KIR - genetics ; Venezuela</subject><ispartof>Tissue antigens, 2010-06, Vol.75 (6), p.724-729</ispartof><rights>2010 John Wiley & Sons A/S</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5436-f67bc22a9a2c6d6bd62604d2ee687f0bbabdc319755fe8b3278582268684b4903</citedby><cites>FETCH-LOGICAL-c5436-f67bc22a9a2c6d6bd62604d2ee687f0bbabdc319755fe8b3278582268684b4903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-0039.2010.01446.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-0039.2010.01446.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20210918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conesa, A.</creatorcontrib><creatorcontrib>Fernández-Mestre, M.</creatorcontrib><creatorcontrib>Padrón, D.</creatorcontrib><creatorcontrib>Toro, F.</creatorcontrib><creatorcontrib>Silva, N.</creatorcontrib><creatorcontrib>Tassinari, P.</creatorcontrib><creatorcontrib>Blanca, I.</creatorcontrib><creatorcontrib>Martin, M.P.</creatorcontrib><creatorcontrib>Carrington, M.</creatorcontrib><creatorcontrib>Layrisse, Z.</creatorcontrib><title>Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela</title><title>Tissue antigens</title><addtitle>Tissue Antigens</addtitle><description>This study represents the first report on the distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all KIR genes are present in this population. Frequency of inhibitory killer cell immunoglobulin‐like receptors (KIRs) exceeded 0.69, except for KIR2DL2 (0.29) and 2DL5 (0.37). Activating KIRs showed low frequencies (0.11–0.29), except for KIR2DS4 (0.68). Forty‐five different KIR genotypes were identified, with a predominance of three genotypes found in 50.7% of the population of which 25.9% were individuals homozygous for haplotype A. The frequencies of KIR genes reflect the ethnic admixture existing in the mestizo Venezuelan population.</description><subject>Gene Frequency</subject><subject>Humans</subject><subject>KIR</subject><subject>mestizo Venezuelan population</subject><subject>natural killer cells</subject><subject>Phylogeny</subject><subject>polymerase chain reaction-sequence-specific primers</subject><subject>Population - genetics</subject><subject>Receptors, KIR - genetics</subject><subject>Venezuela</subject><issn>0001-2815</issn><issn>1399-0039</issn><issn>1399-0039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v0zAcxi0EYmXwFZBvnFL8Fjs-gDQNuiFVQ5MGHC07cTq3ThzsBLp9epx1VHACX_z2ex7778cAQIyWOLe32yWmUhYIUbkkKK8izBhf7p-AxXHjKVgghHBBKlyegBcpbfOMCSmfgxOCCEYSVwuw-eDSGJ2ZRhd6GFq4c97bCGvrPXRdN_Vh44OZvOsL73YWRlvbYQwRbmxvE3Q9HG8t7Gwa3X2AQxgmrx-82hg6-DVD95P1-iV41mqf7KvH_hR8WX28Ob8s1p8vPp2frYu6ZJQXLRemJkRLTWrecNNwwhFriLW8Ei0yRpumpliKsmxtZSgRVVkRwiteMcMkoqfg_cF3mExnm9r2Y9ReDdF1Ot6poJ36e6d3t2oTfihBOaeSZYM3jwYxfJ9yWapzaX4N3dswJSVYyWk-k_-bpJQiXGKSyepA1jGkFG17vA9Gag5UbdWcm5pzU3Og6iFQtc_S13_WcxT-TjAD7w7AT-ft3X8bq5uzq3mU9cVBn_-B3R_1Ou4UF1SU6tvVhbq-XK2uqVgrRn8BXYfApQ</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>Conesa, A.</creator><creator>Fernández-Mestre, M.</creator><creator>Padrón, D.</creator><creator>Toro, F.</creator><creator>Silva, N.</creator><creator>Tassinari, P.</creator><creator>Blanca, I.</creator><creator>Martin, M.P.</creator><creator>Carrington, M.</creator><creator>Layrisse, Z.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201006</creationdate><title>Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela</title><author>Conesa, A. ; Fernández-Mestre, M. ; Padrón, D. ; Toro, F. ; Silva, N. ; Tassinari, P. ; Blanca, I. ; Martin, M.P. ; Carrington, M. ; Layrisse, Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5436-f67bc22a9a2c6d6bd62604d2ee687f0bbabdc319755fe8b3278582268684b4903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Gene Frequency</topic><topic>Humans</topic><topic>KIR</topic><topic>mestizo Venezuelan population</topic><topic>natural killer cells</topic><topic>Phylogeny</topic><topic>polymerase chain reaction-sequence-specific primers</topic><topic>Population - genetics</topic><topic>Receptors, KIR - genetics</topic><topic>Venezuela</topic><toplevel>online_resources</toplevel><creatorcontrib>Conesa, A.</creatorcontrib><creatorcontrib>Fernández-Mestre, M.</creatorcontrib><creatorcontrib>Padrón, D.</creatorcontrib><creatorcontrib>Toro, F.</creatorcontrib><creatorcontrib>Silva, N.</creatorcontrib><creatorcontrib>Tassinari, P.</creatorcontrib><creatorcontrib>Blanca, I.</creatorcontrib><creatorcontrib>Martin, M.P.</creatorcontrib><creatorcontrib>Carrington, M.</creatorcontrib><creatorcontrib>Layrisse, Z.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Tissue antigens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conesa, A.</au><au>Fernández-Mestre, M.</au><au>Padrón, D.</au><au>Toro, F.</au><au>Silva, N.</au><au>Tassinari, P.</au><au>Blanca, I.</au><au>Martin, M.P.</au><au>Carrington, M.</au><au>Layrisse, Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela</atitle><jtitle>Tissue antigens</jtitle><addtitle>Tissue Antigens</addtitle><date>2010-06</date><risdate>2010</risdate><volume>75</volume><issue>6</issue><spage>724</spage><epage>729</epage><pages>724-729</pages><issn>0001-2815</issn><issn>1399-0039</issn><eissn>1399-0039</eissn><abstract>This study represents the first report on the distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all KIR genes are present in this population. Frequency of inhibitory killer cell immunoglobulin‐like receptors (KIRs) exceeded 0.69, except for KIR2DL2 (0.29) and 2DL5 (0.37). Activating KIRs showed low frequencies (0.11–0.29), except for KIR2DS4 (0.68). Forty‐five different KIR genotypes were identified, with a predominance of three genotypes found in 50.7% of the population of which 25.9% were individuals homozygous for haplotype A. The frequencies of KIR genes reflect the ethnic admixture existing in the mestizo Venezuelan population.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20210918</pmid><doi>10.1111/j.1399-0039.2010.01446.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-2815 |
| ispartof | Tissue antigens, 2010-06, Vol.75 (6), p.724-729 |
| issn | 0001-2815 1399-0039 1399-0039 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7366394 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Gene Frequency Humans KIR mestizo Venezuelan population natural killer cells Phylogeny polymerase chain reaction-sequence-specific primers Population - genetics Receptors, KIR - genetics Venezuela |
| title | Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T03%3A10%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Distribution%20of%20killer%20cell%20immunoglobulin-like%20receptor%20genes%20in%20the%20mestizo%20population%20from%20Venezuela&rft.jtitle=Tissue%20antigens&rft.au=Conesa,%20A.&rft.date=2010-06&rft.volume=75&rft.issue=6&rft.spage=724&rft.epage=729&rft.pages=724-729&rft.issn=0001-2815&rft.eissn=1399-0039&rft_id=info:doi/10.1111/j.1399-0039.2010.01446.x&rft_dat=%3Cproquest_pubme%3E745635826%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733301512&rft_id=info:pmid/20210918&rfr_iscdi=true |