Evaluation of the effect of UGT1A1 polymorphisms on the pharmacokinetics of oral and long-acting injectable cabotegravir

Cabotegravir is an HIV integrase inhibitor in clinical development with both oral and long-acting (LA) injectable formulations. Cabotegravir is primarily metabolized by uridine 5'-diphospho-glucuronosyltransferase (UGT) 1A1, a known polymorphic enzyme with functional variants that can affect dr...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2020-08, Vol.75 (8), p.2240-2248
Hauptverfasser:	Patel, Parul, Xue, Zhengyu, King, Karen S, Parham, Laura, Ford, Susan, Lou, Yu, Bakshi, Kalpana K, Sutton, Kenneth, Margolis, David, Hughes, Arlene R, Spreen, William R
Format:	Artikel
Sprache:	eng
Schlagworte:	Original Research
Online-Zugang:	Volltext
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