Structure-based virtual screening of phytochemicals and repurposing of FDA approved antiviral drugs unravels lead molecules as potential inhibitors of coronavirus 3C-like protease enzyme

Coronaviruses are enveloped positive-strand RNA viruses belonging to family Coronaviridae and order Nidovirales which cause infections in birds and mammals. Among the human coronaviruses, highly pathogenic ones are Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and the Middle East Respirat...

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Veröffentlicht in:	Journal of King Saud University. Science 2020-09, Vol.32 (6), p.2845-2853
Hauptverfasser:	Bahadur Gurung, Arun, Ajmal Ali, Mohammad, Lee, Joongku, Abul Farah, Mohammad, Mashay Al-Anazi, Khalid
Format:	Artikel
Sprache:	eng
Schlagworte:	3C-like protease Antiviral drugs Coronaviruses FDA approved drugs MERS-CoV Molecular docking Phytochemicals SARS-CoV Virtual screening
Online-Zugang:	Volltext
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