Facilitating Complex Trait Analysis via Reduced Complexity Crosses

Genetically diverse inbred strains are frequently used in quantitative trait mapping to identify sequence variants underlying trait variation. Poor locus resolution and high genetic complexity impede variant discovery. As a solution, we explore reduced complexity crosses (RCCs) between phenotypicall...

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Veröffentlicht in:	Trends in genetics 2020-08, Vol.36 (8), p.549-562
Hauptverfasser:	Bryant, Camron D., Smith, Desmond J., Kantak, Kathleen M., Nowak, Thaddeus S., Williams, Robert W., Damaj, M. Imad, Redei, Eva E., Chen, Hao, Mulligan, Megan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	functional variant GWAS positional cloning rat genetics substrain, QTL
Online-Zugang:	Volltext
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