Effects of weaning age and housing conditions on phenotypic differences in mice

Poor reproducibility is considered a serious problem in laboratory animal research, with important scientific, economic, and ethical implications. One possible source of conflicting findings in laboratory animal research are environmental differences between animal facilities combined with rigorous...

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Veröffentlicht in:	Scientific reports 2020-07, Vol.10 (1), p.11684, Article 11684
Hauptverfasser:	Bailoo, Jeremy D., Voelkl, Bernhard, Varholick, Justin, Novak, Janja, Murphy, Eimear, Rosso, Marianna, Palme, Rupert, Würbel, Hanno
Format:	Artikel
Sprache:	eng
Schlagworte:	631/158 631/378 Age Age Factors Animal Experimentation - standards Animal research Animals Animals, Laboratory - physiology Animals, Newborn Behavioral plasticity Biological Variation, Individual Body Weight Environmental conditions Female Glucocorticoids Glucocorticoids - metabolism Housing Housing conditions Housing, Animal - standards Humanities and Social Sciences Laboratory animals Male Maze Learning - physiology Metabolites Mice multidisciplinary Open-field behavior Phenotype Phenotypes Phenotypic plasticity Reproducibility of Results Science Science (multidisciplinary) Standardization Weaning
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