Helical tomotherapy with a complete-directional-complete block technique effectively reduces cardiac and lung dose for left-sided breast cancer
To evaluate the feasibility and optimal restricted angle of the complete-directional-complete block (CDCB) technique in helical tomotherapy (HT) by including regional nodal irradiation (RNI) with the internal mammary node (IMN) in left-sided breast cancer. Ten left-sided breast cancer patients treat...
Gespeichert in:
| Veröffentlicht in: | British journal of radiology 2020-04, Vol.93 (1108), p.20190792 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1108 |
| container_start_page | 20190792 |
| container_title | British journal of radiology |
| container_volume | 93 |
| creator | Yeh, Hsin-Pei Huang, Yu-Chuen Wang, Li-Ying Shueng, Pei-Wei Tien, Hui-Ju Chang, Chiu-Han Chou, San-Fang Hsieh, Chen-Hsi |
| description | To evaluate the feasibility and optimal restricted angle of the complete-directional-complete block (CDCB) technique in helical tomotherapy (HT) by including regional nodal irradiation (RNI) with the internal mammary node (IMN) in left-sided breast cancer.
Ten left-sided breast cancer patients treated with 50 Gy in 25 fractions were compared with five-field intensity-modulated radiation therapy (5F-IMRT) and six types of HT plans. In the HT plans, complete block (CB), organ-based directional block (OBDB) and CDCB with different restricted angles were used.
The conformity index (CI) between the CDCB
and 5F-IMRT groups was similar. Compared to CB, OBDB and 5F-IMRT, CDCB
resulted in a decreased ipsilateral mean lung dose. The low-dose region (V
) of the ipsilateral lung in OBDB (84.0%) was the highest among all techniques (
< 0.001). The mean dose of the heart in CB was significantly reduced (by 11.5-22.4%) compared with other techniques. The V
of the heart in CDCB
(1.9%) was significantly lower than that of CB, OBDB and 5F-IMRT. Compared to the mean dose of the left anterior descending (LAD) artery of 5F-IMRT (27.0 Gy), CDCB
, CDCB
, CDCB
, CDCB
and OBDB reduced the mean dose effectively by 31.7%, 38.3%, 39.6%, 42.0 and 56.2%, respectively. Considering the parameters of the organs-at-risk (OARs), CDCB
had higher expectative values than the other techniques (
= 0.01).
HT with the CDCB technique is feasible for treating left-sided breast cancer patients. The CDCB
techniques not only achieved similar planning target volume coverage, homogeneity and dose conformity but also allowed better sparing of the heart and bilateral lungs.
For left-sided breast cancer patients whose RNI field includes the IMN, heart avoidance is an important issue. The CDCB technique achieved good PTV coverage, homogeneity and dose conformity and allowed better sparing of the mean dose of the lung, the LAD artery, and the heart and reduced the V
of the heart. |
| doi_str_mv | 10.1259/bjr.20190792 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7362916</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>31939310</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-29ea53fcbe73f5f397c0ceb1dcaffde35a70c760022adac92e72e3cb7c16b78c3</originalsourceid><addsrcrecordid>eNpVkc9OGzEQh60KVAL01nPlB2Cp_2Tj9aVShShUQuICErfV7HhMTJ11ajtBeYq-MonSoPY0mplvfnP4GPssxaVUrf06vORLJaQVxqoPbCLNtGu6TjwdsYkQwjRSde0JOy3lZde2VnxkJ1pabbUUE_bnlmJAiLymRapzyrDc8NdQ5xw4psUyUqXGhUxYQxohNochH2LCX7wSzsfwe0WcvN9Ba4obnsmtkApHyC4Achgdj6vxmbtUiPuUeSRfmxIcOT5kglK37IiUz9mxh1jo0996xh5_XD9c3TZ39zc_r77fNai7aW2UJWi1x4GM9q3X1qBAGqRD8N6RbsEINDMhlAIHaBUZRRoHg3I2mA71Gfu2z12uhgU5pLFmiP0yhwXkTZ8g9P9vxjDvn9O6N3qmrJxtAy72AZhTKZn8-60U_U5MvxXTH8Rs8S___nuHDyb0G_JOkBQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Helical tomotherapy with a complete-directional-complete block technique effectively reduces cardiac and lung dose for left-sided breast cancer</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Yeh, Hsin-Pei ; Huang, Yu-Chuen ; Wang, Li-Ying ; Shueng, Pei-Wei ; Tien, Hui-Ju ; Chang, Chiu-Han ; Chou, San-Fang ; Hsieh, Chen-Hsi</creator><creatorcontrib>Yeh, Hsin-Pei ; Huang, Yu-Chuen ; Wang, Li-Ying ; Shueng, Pei-Wei ; Tien, Hui-Ju ; Chang, Chiu-Han ; Chou, San-Fang ; Hsieh, Chen-Hsi</creatorcontrib><description>To evaluate the feasibility and optimal restricted angle of the complete-directional-complete block (CDCB) technique in helical tomotherapy (HT) by including regional nodal irradiation (RNI) with the internal mammary node (IMN) in left-sided breast cancer.
Ten left-sided breast cancer patients treated with 50 Gy in 25 fractions were compared with five-field intensity-modulated radiation therapy (5F-IMRT) and six types of HT plans. In the HT plans, complete block (CB), organ-based directional block (OBDB) and CDCB with different restricted angles were used.
The conformity index (CI) between the CDCB
and 5F-IMRT groups was similar. Compared to CB, OBDB and 5F-IMRT, CDCB
resulted in a decreased ipsilateral mean lung dose. The low-dose region (V
) of the ipsilateral lung in OBDB (84.0%) was the highest among all techniques (
< 0.001). The mean dose of the heart in CB was significantly reduced (by 11.5-22.4%) compared with other techniques. The V
of the heart in CDCB
(1.9%) was significantly lower than that of CB, OBDB and 5F-IMRT. Compared to the mean dose of the left anterior descending (LAD) artery of 5F-IMRT (27.0 Gy), CDCB
, CDCB
, CDCB
, CDCB
and OBDB reduced the mean dose effectively by 31.7%, 38.3%, 39.6%, 42.0 and 56.2%, respectively. Considering the parameters of the organs-at-risk (OARs), CDCB
had higher expectative values than the other techniques (
= 0.01).
HT with the CDCB technique is feasible for treating left-sided breast cancer patients. The CDCB
techniques not only achieved similar planning target volume coverage, homogeneity and dose conformity but also allowed better sparing of the heart and bilateral lungs.
For left-sided breast cancer patients whose RNI field includes the IMN, heart avoidance is an important issue. The CDCB technique achieved good PTV coverage, homogeneity and dose conformity and allowed better sparing of the mean dose of the lung, the LAD artery, and the heart and reduced the V
of the heart.</description><identifier>ISSN: 0007-1285</identifier><identifier>EISSN: 1748-880X</identifier><identifier>DOI: 10.1259/bjr.20190792</identifier><identifier>PMID: 31939310</identifier><language>eng</language><publisher>England: The British Institute of Radiology</publisher><subject>Dose Fractionation, Radiation ; Feasibility Studies ; Female ; Heart - radiation effects ; Humans ; Lung - radiation effects ; Lymphatic Irradiation - methods ; Organs at Risk - diagnostic imaging ; Organs at Risk - radiation effects ; Radiation Injuries - prevention & control ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Intensity-Modulated - methods ; Unilateral Breast Neoplasms - diagnostic imaging ; Unilateral Breast Neoplasms - radiotherapy</subject><ispartof>British journal of radiology, 2020-04, Vol.93 (1108), p.20190792</ispartof><rights>2020 The Authors. Published by the British Institute of Radiology 2020 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-29ea53fcbe73f5f397c0ceb1dcaffde35a70c760022adac92e72e3cb7c16b78c3</citedby><cites>FETCH-LOGICAL-c384t-29ea53fcbe73f5f397c0ceb1dcaffde35a70c760022adac92e72e3cb7c16b78c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31939310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeh, Hsin-Pei</creatorcontrib><creatorcontrib>Huang, Yu-Chuen</creatorcontrib><creatorcontrib>Wang, Li-Ying</creatorcontrib><creatorcontrib>Shueng, Pei-Wei</creatorcontrib><creatorcontrib>Tien, Hui-Ju</creatorcontrib><creatorcontrib>Chang, Chiu-Han</creatorcontrib><creatorcontrib>Chou, San-Fang</creatorcontrib><creatorcontrib>Hsieh, Chen-Hsi</creatorcontrib><title>Helical tomotherapy with a complete-directional-complete block technique effectively reduces cardiac and lung dose for left-sided breast cancer</title><title>British journal of radiology</title><addtitle>Br J Radiol</addtitle><description>To evaluate the feasibility and optimal restricted angle of the complete-directional-complete block (CDCB) technique in helical tomotherapy (HT) by including regional nodal irradiation (RNI) with the internal mammary node (IMN) in left-sided breast cancer.
Ten left-sided breast cancer patients treated with 50 Gy in 25 fractions were compared with five-field intensity-modulated radiation therapy (5F-IMRT) and six types of HT plans. In the HT plans, complete block (CB), organ-based directional block (OBDB) and CDCB with different restricted angles were used.
The conformity index (CI) between the CDCB
and 5F-IMRT groups was similar. Compared to CB, OBDB and 5F-IMRT, CDCB
resulted in a decreased ipsilateral mean lung dose. The low-dose region (V
) of the ipsilateral lung in OBDB (84.0%) was the highest among all techniques (
< 0.001). The mean dose of the heart in CB was significantly reduced (by 11.5-22.4%) compared with other techniques. The V
of the heart in CDCB
(1.9%) was significantly lower than that of CB, OBDB and 5F-IMRT. Compared to the mean dose of the left anterior descending (LAD) artery of 5F-IMRT (27.0 Gy), CDCB
, CDCB
, CDCB
, CDCB
and OBDB reduced the mean dose effectively by 31.7%, 38.3%, 39.6%, 42.0 and 56.2%, respectively. Considering the parameters of the organs-at-risk (OARs), CDCB
had higher expectative values than the other techniques (
= 0.01).
HT with the CDCB technique is feasible for treating left-sided breast cancer patients. The CDCB
techniques not only achieved similar planning target volume coverage, homogeneity and dose conformity but also allowed better sparing of the heart and bilateral lungs.
For left-sided breast cancer patients whose RNI field includes the IMN, heart avoidance is an important issue. The CDCB technique achieved good PTV coverage, homogeneity and dose conformity and allowed better sparing of the mean dose of the lung, the LAD artery, and the heart and reduced the V
of the heart.</description><subject>Dose Fractionation, Radiation</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Heart - radiation effects</subject><subject>Humans</subject><subject>Lung - radiation effects</subject><subject>Lymphatic Irradiation - methods</subject><subject>Organs at Risk - diagnostic imaging</subject><subject>Organs at Risk - radiation effects</subject><subject>Radiation Injuries - prevention & control</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>Unilateral Breast Neoplasms - diagnostic imaging</subject><subject>Unilateral Breast Neoplasms - radiotherapy</subject><issn>0007-1285</issn><issn>1748-880X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9OGzEQh60KVAL01nPlB2Cp_2Tj9aVShShUQuICErfV7HhMTJ11ajtBeYq-MonSoPY0mplvfnP4GPssxaVUrf06vORLJaQVxqoPbCLNtGu6TjwdsYkQwjRSde0JOy3lZde2VnxkJ1pabbUUE_bnlmJAiLymRapzyrDc8NdQ5xw4psUyUqXGhUxYQxohNochH2LCX7wSzsfwe0WcvN9Ba4obnsmtkApHyC4Achgdj6vxmbtUiPuUeSRfmxIcOT5kglK37IiUz9mxh1jo0996xh5_XD9c3TZ39zc_r77fNai7aW2UJWi1x4GM9q3X1qBAGqRD8N6RbsEINDMhlAIHaBUZRRoHg3I2mA71Gfu2z12uhgU5pLFmiP0yhwXkTZ8g9P9vxjDvn9O6N3qmrJxtAy72AZhTKZn8-60U_U5MvxXTH8Rs8S___nuHDyb0G_JOkBQ</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Yeh, Hsin-Pei</creator><creator>Huang, Yu-Chuen</creator><creator>Wang, Li-Ying</creator><creator>Shueng, Pei-Wei</creator><creator>Tien, Hui-Ju</creator><creator>Chang, Chiu-Han</creator><creator>Chou, San-Fang</creator><creator>Hsieh, Chen-Hsi</creator><general>The British Institute of Radiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200401</creationdate><title>Helical tomotherapy with a complete-directional-complete block technique effectively reduces cardiac and lung dose for left-sided breast cancer</title><author>Yeh, Hsin-Pei ; Huang, Yu-Chuen ; Wang, Li-Ying ; Shueng, Pei-Wei ; Tien, Hui-Ju ; Chang, Chiu-Han ; Chou, San-Fang ; Hsieh, Chen-Hsi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-29ea53fcbe73f5f397c0ceb1dcaffde35a70c760022adac92e72e3cb7c16b78c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Dose Fractionation, Radiation</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Heart - radiation effects</topic><topic>Humans</topic><topic>Lung - radiation effects</topic><topic>Lymphatic Irradiation - methods</topic><topic>Organs at Risk - diagnostic imaging</topic><topic>Organs at Risk - radiation effects</topic><topic>Radiation Injuries - prevention & control</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>Unilateral Breast Neoplasms - diagnostic imaging</topic><topic>Unilateral Breast Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, Hsin-Pei</creatorcontrib><creatorcontrib>Huang, Yu-Chuen</creatorcontrib><creatorcontrib>Wang, Li-Ying</creatorcontrib><creatorcontrib>Shueng, Pei-Wei</creatorcontrib><creatorcontrib>Tien, Hui-Ju</creatorcontrib><creatorcontrib>Chang, Chiu-Han</creatorcontrib><creatorcontrib>Chou, San-Fang</creatorcontrib><creatorcontrib>Hsieh, Chen-Hsi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, Hsin-Pei</au><au>Huang, Yu-Chuen</au><au>Wang, Li-Ying</au><au>Shueng, Pei-Wei</au><au>Tien, Hui-Ju</au><au>Chang, Chiu-Han</au><au>Chou, San-Fang</au><au>Hsieh, Chen-Hsi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Helical tomotherapy with a complete-directional-complete block technique effectively reduces cardiac and lung dose for left-sided breast cancer</atitle><jtitle>British journal of radiology</jtitle><addtitle>Br J Radiol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>93</volume><issue>1108</issue><spage>20190792</spage><pages>20190792-</pages><issn>0007-1285</issn><eissn>1748-880X</eissn><abstract>To evaluate the feasibility and optimal restricted angle of the complete-directional-complete block (CDCB) technique in helical tomotherapy (HT) by including regional nodal irradiation (RNI) with the internal mammary node (IMN) in left-sided breast cancer.
Ten left-sided breast cancer patients treated with 50 Gy in 25 fractions were compared with five-field intensity-modulated radiation therapy (5F-IMRT) and six types of HT plans. In the HT plans, complete block (CB), organ-based directional block (OBDB) and CDCB with different restricted angles were used.
The conformity index (CI) between the CDCB
and 5F-IMRT groups was similar. Compared to CB, OBDB and 5F-IMRT, CDCB
resulted in a decreased ipsilateral mean lung dose. The low-dose region (V
) of the ipsilateral lung in OBDB (84.0%) was the highest among all techniques (
< 0.001). The mean dose of the heart in CB was significantly reduced (by 11.5-22.4%) compared with other techniques. The V
of the heart in CDCB
(1.9%) was significantly lower than that of CB, OBDB and 5F-IMRT. Compared to the mean dose of the left anterior descending (LAD) artery of 5F-IMRT (27.0 Gy), CDCB
, CDCB
, CDCB
, CDCB
and OBDB reduced the mean dose effectively by 31.7%, 38.3%, 39.6%, 42.0 and 56.2%, respectively. Considering the parameters of the organs-at-risk (OARs), CDCB
had higher expectative values than the other techniques (
= 0.01).
HT with the CDCB technique is feasible for treating left-sided breast cancer patients. The CDCB
techniques not only achieved similar planning target volume coverage, homogeneity and dose conformity but also allowed better sparing of the heart and bilateral lungs.
For left-sided breast cancer patients whose RNI field includes the IMN, heart avoidance is an important issue. The CDCB technique achieved good PTV coverage, homogeneity and dose conformity and allowed better sparing of the mean dose of the lung, the LAD artery, and the heart and reduced the V
of the heart.</abstract><cop>England</cop><pub>The British Institute of Radiology</pub><pmid>31939310</pmid><doi>10.1259/bjr.20190792</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1285 |
| ispartof | British journal of radiology, 2020-04, Vol.93 (1108), p.20190792 |
| issn | 0007-1285 1748-880X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7362916 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Dose Fractionation, Radiation Feasibility Studies Female Heart - radiation effects Humans Lung - radiation effects Lymphatic Irradiation - methods Organs at Risk - diagnostic imaging Organs at Risk - radiation effects Radiation Injuries - prevention & control Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - methods Unilateral Breast Neoplasms - diagnostic imaging Unilateral Breast Neoplasms - radiotherapy |
| title | Helical tomotherapy with a complete-directional-complete block technique effectively reduces cardiac and lung dose for left-sided breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T03%3A10%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Helical%20tomotherapy%20with%20a%20complete-directional-complete%20block%20technique%20effectively%20reduces%20cardiac%20and%20lung%20dose%20for%20left-sided%20breast%20cancer&rft.jtitle=British%20journal%20of%20radiology&rft.au=Yeh,%20Hsin-Pei&rft.date=2020-04-01&rft.volume=93&rft.issue=1108&rft.spage=20190792&rft.pages=20190792-&rft.issn=0007-1285&rft.eissn=1748-880X&rft_id=info:doi/10.1259/bjr.20190792&rft_dat=%3Cpubmed_cross%3E31939310%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/31939310&rfr_iscdi=true |