HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia

In mammalian cells, cytosines found within cytosine guanine dinucleotides can be methylated to 5-methylcytosine (5-mC) by DNA methyltransferases and further oxidized by the Ten-eleven translocation dioxygenase (TET) enzymes to 5-hydroxymethylcytosine (5-hmC). We have previously shown that hematopoie...

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Veröffentlicht in:	Blood advances 2020-07, Vol.4 (13), p.3053-3062
Hauptverfasser:	Cao, John Z., Liu, Hui, Wickrema, Amittha, Godley, Lucy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytosine Dioxygenases - genetics DNA-Binding Proteins - genetics Gene Expression Humans Hypoxia - genetics Proto-Oncogene Proteins - genetics Red Cells, Iron, and Erythropoiesis
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