Distribution of Human Papillomavirus and Antisperm Antibody in Semen and Its Association with Semen Parameters Among Infertile Men
Sexually transmitted infections (STIs) can be associated with infertility. Human papillomavirus (HPV) has been identified as a potential agent in male infertility. Also, anti-sperm antibodies (ASA) have been detected in men with infertility. The aim of this study was to investigate the prevalence an...
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| Veröffentlicht in: | Journal of reproduction & infertility 2020-07, Vol.21 (3), p.183-188 |
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| container_title | Journal of reproduction & infertility |
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| creator | Piroozmand, Ahmad Mousavi Nasab, Seyed Dawood Erami, Mahzad Hashemi, Seyed Mohammad Ali Khodabakhsh, Elnaz Ahmadi, Nayebali Vahedpoor, Zahra |
| description | Sexually transmitted infections (STIs) can be associated with infertility. Human papillomavirus (HPV) has been identified as a potential agent in male infertility. Also, anti-sperm antibodies (ASA) have been detected in men with infertility. The aim of this study was to investigate the prevalence and association of HPV and ASA in infected semen of infertile men.
This cross-sectional study was performed on 96 infertile men referring to infertility treatment center of Kashan University of Medical Sciences during March 2017 till September 2017 in Iran. Semen analysis and diagnostic PCR test were performed for detection of HPV DNA. The semen parameters in HPV infected and ASA positive samples were compared with HPV non-infected and ASA negative samples. Chi square test was used to determine the correlation between variables and p |
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This cross-sectional study was performed on 96 infertile men referring to infertility treatment center of Kashan University of Medical Sciences during March 2017 till September 2017 in Iran. Semen analysis and diagnostic PCR test were performed for detection of HPV DNA. The semen parameters in HPV infected and ASA positive samples were compared with HPV non-infected and ASA negative samples. Chi square test was used to determine the correlation between variables and p<0.05 was considered statistically significant.
HPV DNA and ASA were detected in 17.4% and 15.2% of 96 semen samples, respectively. Semen volume, sperm count, sperm motility and the normal morphology rate were significantly decreased in HPV-positive subjects (p=0.004, p= 0.016, p<0.001, and p=0.017, respectively). Also, sperm motility was significantly decreased in ASA-positive subjects (p=0.002), also patients with HPV infection had a higher rate of ASA than the non-HPV group. In contrast to ASA, HPV infection had a significant correlation with education level (p=0.039).
The findings suggest that asymptomatic seminal infection of HPV and ASA by adversely affecting sperm quality, in particular sperm motility and count, may play an important role in male infertility.</description><identifier>ISSN: 2228-5482</identifier><identifier>EISSN: 2251-676X</identifier><identifier>PMID: 32685415</identifier><language>eng</language><publisher>Iran: Office for Scientific Journals</publisher><subject>Antibodies ; Chi-square test ; Deoxyribonucleic acid ; DNA ; Human papillomavirus ; Infections ; Infertility ; Medical treatment ; Motility ; Original ; Parameters ; Semen ; Sexually transmitted diseases ; Sperm ; Statistical analysis ; Statistical methods ; Statistical tests ; STD</subject><ispartof>Journal of reproduction & infertility, 2020-07, Vol.21 (3), p.183-188</ispartof><rights>Copyright© 2020, Avicenna Research Institute.</rights><rights>Copyright Office for Scientific Journals 2020</rights><rights>Copyright© 2020, Avicenna Research Institute. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362092/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362092/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32685415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piroozmand, Ahmad</creatorcontrib><creatorcontrib>Mousavi Nasab, Seyed Dawood</creatorcontrib><creatorcontrib>Erami, Mahzad</creatorcontrib><creatorcontrib>Hashemi, Seyed Mohammad Ali</creatorcontrib><creatorcontrib>Khodabakhsh, Elnaz</creatorcontrib><creatorcontrib>Ahmadi, Nayebali</creatorcontrib><creatorcontrib>Vahedpoor, Zahra</creatorcontrib><title>Distribution of Human Papillomavirus and Antisperm Antibody in Semen and Its Association with Semen Parameters Among Infertile Men</title><title>Journal of reproduction & infertility</title><addtitle>J Reprod Infertil</addtitle><description>Sexually transmitted infections (STIs) can be associated with infertility. Human papillomavirus (HPV) has been identified as a potential agent in male infertility. Also, anti-sperm antibodies (ASA) have been detected in men with infertility. The aim of this study was to investigate the prevalence and association of HPV and ASA in infected semen of infertile men.
This cross-sectional study was performed on 96 infertile men referring to infertility treatment center of Kashan University of Medical Sciences during March 2017 till September 2017 in Iran. Semen analysis and diagnostic PCR test were performed for detection of HPV DNA. The semen parameters in HPV infected and ASA positive samples were compared with HPV non-infected and ASA negative samples. Chi square test was used to determine the correlation between variables and p<0.05 was considered statistically significant.
HPV DNA and ASA were detected in 17.4% and 15.2% of 96 semen samples, respectively. Semen volume, sperm count, sperm motility and the normal morphology rate were significantly decreased in HPV-positive subjects (p=0.004, p= 0.016, p<0.001, and p=0.017, respectively). Also, sperm motility was significantly decreased in ASA-positive subjects (p=0.002), also patients with HPV infection had a higher rate of ASA than the non-HPV group. In contrast to ASA, HPV infection had a significant correlation with education level (p=0.039).
The findings suggest that asymptomatic seminal infection of HPV and ASA by adversely affecting sperm quality, in particular sperm motility and count, may play an important role in male infertility.</description><subject>Antibodies</subject><subject>Chi-square test</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Human papillomavirus</subject><subject>Infections</subject><subject>Infertility</subject><subject>Medical treatment</subject><subject>Motility</subject><subject>Original</subject><subject>Parameters</subject><subject>Semen</subject><subject>Sexually transmitted diseases</subject><subject>Sperm</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Statistical tests</subject><subject>STD</subject><issn>2228-5482</issn><issn>2251-676X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkV9LwzAUxYsobky_ggR88aWwJE2XvAhj_tlAcaCCbyVtb11Gk9QkVfbqJzfOKep9uQfOj8O53L1kSAjDaT7Jn_Y_NeEpyzgZJMfer8dxhMCEisNkQEnOWYbZMHm_UD44VfZBWYNsg-a9lgYtZafa1mr5qlzvkTQ1mpqgfAdOb1Vp6w1SBt2DBrP1F8Gjqfe2UnKb9abCamcvpZMaArhIaGue0cI04IJqAd2COUoOGtl6ON7tUfJ4dfkwm6c3d9eL2fQm7chYhFTwpsSClyxrMswZxjlQ4FSWvAQpqGzGVIyhylhNscRCVNUEas5ojhvBGcnpKDn_yu36UkNdgQlOtkXnlJZuU1ipir-OUavi2b4WE5rHBiQGnO0CnH3pwYdCK19B20oDtvcFyQhjIot0RE__oWvbOxPPK0iOY1OOxSRSJ78b_VT5fg_9AAZKj5Q</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Piroozmand, Ahmad</creator><creator>Mousavi Nasab, Seyed Dawood</creator><creator>Erami, Mahzad</creator><creator>Hashemi, Seyed Mohammad Ali</creator><creator>Khodabakhsh, Elnaz</creator><creator>Ahmadi, Nayebali</creator><creator>Vahedpoor, Zahra</creator><general>Office for Scientific Journals</general><general>Avicenna Research Institute</general><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200701</creationdate><title>Distribution of Human Papillomavirus and Antisperm Antibody in Semen and Its Association with Semen Parameters Among Infertile Men</title><author>Piroozmand, Ahmad ; Mousavi Nasab, Seyed Dawood ; Erami, Mahzad ; Hashemi, Seyed Mohammad Ali ; Khodabakhsh, Elnaz ; Ahmadi, Nayebali ; Vahedpoor, Zahra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-98fb198b54f4185116e3e83ab8bea93af0390ec45d31a199cc7ed85361f985263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibodies</topic><topic>Chi-square test</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Human papillomavirus</topic><topic>Infections</topic><topic>Infertility</topic><topic>Medical treatment</topic><topic>Motility</topic><topic>Original</topic><topic>Parameters</topic><topic>Semen</topic><topic>Sexually transmitted diseases</topic><topic>Sperm</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Statistical tests</topic><topic>STD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piroozmand, Ahmad</creatorcontrib><creatorcontrib>Mousavi Nasab, Seyed Dawood</creatorcontrib><creatorcontrib>Erami, Mahzad</creatorcontrib><creatorcontrib>Hashemi, Seyed Mohammad Ali</creatorcontrib><creatorcontrib>Khodabakhsh, Elnaz</creatorcontrib><creatorcontrib>Ahmadi, Nayebali</creatorcontrib><creatorcontrib>Vahedpoor, Zahra</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of reproduction & infertility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piroozmand, Ahmad</au><au>Mousavi Nasab, Seyed Dawood</au><au>Erami, Mahzad</au><au>Hashemi, Seyed Mohammad Ali</au><au>Khodabakhsh, Elnaz</au><au>Ahmadi, Nayebali</au><au>Vahedpoor, Zahra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of Human Papillomavirus and Antisperm Antibody in Semen and Its Association with Semen Parameters Among Infertile Men</atitle><jtitle>Journal of reproduction & infertility</jtitle><addtitle>J Reprod Infertil</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>21</volume><issue>3</issue><spage>183</spage><epage>188</epage><pages>183-188</pages><issn>2228-5482</issn><eissn>2251-676X</eissn><abstract>Sexually transmitted infections (STIs) can be associated with infertility. Human papillomavirus (HPV) has been identified as a potential agent in male infertility. Also, anti-sperm antibodies (ASA) have been detected in men with infertility. The aim of this study was to investigate the prevalence and association of HPV and ASA in infected semen of infertile men.
This cross-sectional study was performed on 96 infertile men referring to infertility treatment center of Kashan University of Medical Sciences during March 2017 till September 2017 in Iran. Semen analysis and diagnostic PCR test were performed for detection of HPV DNA. The semen parameters in HPV infected and ASA positive samples were compared with HPV non-infected and ASA negative samples. Chi square test was used to determine the correlation between variables and p<0.05 was considered statistically significant.
HPV DNA and ASA were detected in 17.4% and 15.2% of 96 semen samples, respectively. Semen volume, sperm count, sperm motility and the normal morphology rate were significantly decreased in HPV-positive subjects (p=0.004, p= 0.016, p<0.001, and p=0.017, respectively). Also, sperm motility was significantly decreased in ASA-positive subjects (p=0.002), also patients with HPV infection had a higher rate of ASA than the non-HPV group. In contrast to ASA, HPV infection had a significant correlation with education level (p=0.039).
The findings suggest that asymptomatic seminal infection of HPV and ASA by adversely affecting sperm quality, in particular sperm motility and count, may play an important role in male infertility.</abstract><cop>Iran</cop><pub>Office for Scientific Journals</pub><pmid>32685415</pmid><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of reproduction & infertility, 2020-07, Vol.21 (3), p.183-188 |
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| subjects | Antibodies Chi-square test Deoxyribonucleic acid DNA Human papillomavirus Infections Infertility Medical treatment Motility Original Parameters Semen Sexually transmitted diseases Sperm Statistical analysis Statistical methods Statistical tests STD |
| title | Distribution of Human Papillomavirus and Antisperm Antibody in Semen and Its Association with Semen Parameters Among Infertile Men |
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