Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications
Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded a...
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| Veröffentlicht in: | Polymers 2020-05, Vol.12 (6), p.1233 |
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| creator | Abdullah, Turdimuhammad Gauthaman, Kalamegam Hammad, Ahmed Joshi Navare, Kasturi Alshahrie, Ahmed Bencherif, Sidi Tamayol, Ali Memic, Adnan |
| description | Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. To address this issue, we designed oxygen-releasing electrospun composite scaffolds, based on a previously developed hybrid polymeric matrix composed of poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL). By performing ball-milling, we were able to embed a large percent of calcium peroxide (CP) nanoparticles into the PGS/PCL nanofibers able to generate oxygen. The composite scaffold exhibited a smooth fiber structure, while providing sustainable oxygen release for several days to a week, and significantly improved cell metabolic activity due to alleviation of hypoxic environment around primary bone-marrow-derived mesenchymal stem cells (BM-MSCs). Moreover, the composite scaffolds also showed good antibacterial performance. In conjunction to other improved features, such as degradation behavior, the developed scaffolds are promising biomaterials for various tissue-engineering and wound-healing applications. |
| doi_str_mv | 10.3390/polym12061233 |
| format | Article |
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Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. To address this issue, we designed oxygen-releasing electrospun composite scaffolds, based on a previously developed hybrid polymeric matrix composed of poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL). By performing ball-milling, we were able to embed a large percent of calcium peroxide (CP) nanoparticles into the PGS/PCL nanofibers able to generate oxygen. The composite scaffold exhibited a smooth fiber structure, while providing sustainable oxygen release for several days to a week, and significantly improved cell metabolic activity due to alleviation of hypoxic environment around primary bone-marrow-derived mesenchymal stem cells (BM-MSCs). Moreover, the composite scaffolds also showed good antibacterial performance. In conjunction to other improved features, such as degradation behavior, the developed scaffolds are promising biomaterials for various tissue-engineering and wound-healing applications.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym12061233</identifier><identifier>PMID: 32485817</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Analysis ; Antiinfectives and antibacterials ; Antimicrobial agents ; Ball milling ; Biomedical materials ; Bone marrow ; Composite materials ; Glycerol ; Identification and classification ; Microscopy ; Nanofibers ; Nanoparticles ; Oxygen ; Polyesters ; Polymers ; Properties ; Proteins ; Public health ; Scaffolds ; Stem cells ; Structure ; Surgical implants ; Tissue engineering ; Transplants & implants ; Wound healing</subject><ispartof>Polymers, 2020-05, Vol.12 (6), p.1233</ispartof><rights>COPYRIGHT 2020 MDPI AG</rights><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-e25d0bbe81d5e2cd08e51ae58e6d046d95819c97bbe03f03397de47b38c5239f3</citedby><cites>FETCH-LOGICAL-c420t-e25d0bbe81d5e2cd08e51ae58e6d046d95819c97bbe03f03397de47b38c5239f3</cites><orcidid>0000-0003-3335-4561 ; 0000-0002-7704-5608 ; 0000-0002-3096-1131 ; 0000-0002-4529-8731</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361702/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361702/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Abdullah, Turdimuhammad</creatorcontrib><creatorcontrib>Gauthaman, Kalamegam</creatorcontrib><creatorcontrib>Hammad, Ahmed</creatorcontrib><creatorcontrib>Joshi Navare, Kasturi</creatorcontrib><creatorcontrib>Alshahrie, Ahmed</creatorcontrib><creatorcontrib>Bencherif, Sidi</creatorcontrib><creatorcontrib>Tamayol, Ali</creatorcontrib><creatorcontrib>Memic, Adnan</creatorcontrib><title>Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications</title><title>Polymers</title><description>Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. To address this issue, we designed oxygen-releasing electrospun composite scaffolds, based on a previously developed hybrid polymeric matrix composed of poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL). By performing ball-milling, we were able to embed a large percent of calcium peroxide (CP) nanoparticles into the PGS/PCL nanofibers able to generate oxygen. The composite scaffold exhibited a smooth fiber structure, while providing sustainable oxygen release for several days to a week, and significantly improved cell metabolic activity due to alleviation of hypoxic environment around primary bone-marrow-derived mesenchymal stem cells (BM-MSCs). Moreover, the composite scaffolds also showed good antibacterial performance. In conjunction to other improved features, such as degradation behavior, the developed scaffolds are promising biomaterials for various tissue-engineering and wound-healing applications.</description><subject>Analysis</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Ball milling</subject><subject>Biomedical materials</subject><subject>Bone marrow</subject><subject>Composite materials</subject><subject>Glycerol</subject><subject>Identification and classification</subject><subject>Microscopy</subject><subject>Nanofibers</subject><subject>Nanoparticles</subject><subject>Oxygen</subject><subject>Polyesters</subject><subject>Polymers</subject><subject>Properties</subject><subject>Proteins</subject><subject>Public health</subject><subject>Scaffolds</subject><subject>Stem cells</subject><subject>Structure</subject><subject>Surgical implants</subject><subject>Tissue engineering</subject><subject>Transplants & implants</subject><subject>Wound healing</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkc1LHTEUxUNpqWJddj_gxs3UfE4mG-EhtgpSobXQXchkbsZIXjJNZqTvvzcPpWjvJhfyy7nn5CL0meAvjCl8Nqew2xKKO0IZe4cOKZas5azD71_1B-i4lAdci4uuI_IjOmCU96In8hD9vv27myC2PyCAKT5OzSYufjB2gexNaL6bmJwfclpL89Ma51IYS-NSbu58KSs0l3HyESq8fzrPwVuz-BTLJ_TBmVDg-OU8Qr--Xt5dXLU3t9-uLzY3reUULy1QMeJhgJ6MAqgdcQ-CGBA9dCPm3aiqTWWVrAhmDtfUcgQuB9ZbQZly7AidP-vO67CF0UJcsgl6zn5r8k4n4_Xbm-jv9ZQetWT1LzCtAqcvAjn9WaEseuuLhRBMhJpaU44VUZyorqIn_6EPac2xxttTvSSdkK-oyQTQPrpU59q9qN5IwXqpBOOVap8pm1MpGdw_ywTr_XL1m-WyJ3JllwA</recordid><startdate>20200529</startdate><enddate>20200529</enddate><creator>Abdullah, Turdimuhammad</creator><creator>Gauthaman, Kalamegam</creator><creator>Hammad, Ahmed</creator><creator>Joshi Navare, Kasturi</creator><creator>Alshahrie, Ahmed</creator><creator>Bencherif, Sidi</creator><creator>Tamayol, Ali</creator><creator>Memic, Adnan</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3335-4561</orcidid><orcidid>https://orcid.org/0000-0002-7704-5608</orcidid><orcidid>https://orcid.org/0000-0002-3096-1131</orcidid><orcidid>https://orcid.org/0000-0002-4529-8731</orcidid></search><sort><creationdate>20200529</creationdate><title>Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications</title><author>Abdullah, Turdimuhammad ; Gauthaman, Kalamegam ; Hammad, Ahmed ; Joshi Navare, Kasturi ; Alshahrie, Ahmed ; Bencherif, Sidi ; Tamayol, Ali ; Memic, Adnan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-e25d0bbe81d5e2cd08e51ae58e6d046d95819c97bbe03f03397de47b38c5239f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Ball milling</topic><topic>Biomedical materials</topic><topic>Bone marrow</topic><topic>Composite materials</topic><topic>Glycerol</topic><topic>Identification and classification</topic><topic>Microscopy</topic><topic>Nanofibers</topic><topic>Nanoparticles</topic><topic>Oxygen</topic><topic>Polyesters</topic><topic>Polymers</topic><topic>Properties</topic><topic>Proteins</topic><topic>Public health</topic><topic>Scaffolds</topic><topic>Stem cells</topic><topic>Structure</topic><topic>Surgical implants</topic><topic>Tissue engineering</topic><topic>Transplants & implants</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdullah, Turdimuhammad</creatorcontrib><creatorcontrib>Gauthaman, Kalamegam</creatorcontrib><creatorcontrib>Hammad, Ahmed</creatorcontrib><creatorcontrib>Joshi Navare, Kasturi</creatorcontrib><creatorcontrib>Alshahrie, Ahmed</creatorcontrib><creatorcontrib>Bencherif, Sidi</creatorcontrib><creatorcontrib>Tamayol, Ali</creatorcontrib><creatorcontrib>Memic, Adnan</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdullah, Turdimuhammad</au><au>Gauthaman, Kalamegam</au><au>Hammad, Ahmed</au><au>Joshi Navare, Kasturi</au><au>Alshahrie, Ahmed</au><au>Bencherif, Sidi</au><au>Tamayol, Ali</au><au>Memic, Adnan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications</atitle><jtitle>Polymers</jtitle><date>2020-05-29</date><risdate>2020</risdate><volume>12</volume><issue>6</issue><spage>1233</spage><pages>1233-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. To address this issue, we designed oxygen-releasing electrospun composite scaffolds, based on a previously developed hybrid polymeric matrix composed of poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL). By performing ball-milling, we were able to embed a large percent of calcium peroxide (CP) nanoparticles into the PGS/PCL nanofibers able to generate oxygen. The composite scaffold exhibited a smooth fiber structure, while providing sustainable oxygen release for several days to a week, and significantly improved cell metabolic activity due to alleviation of hypoxic environment around primary bone-marrow-derived mesenchymal stem cells (BM-MSCs). Moreover, the composite scaffolds also showed good antibacterial performance. In conjunction to other improved features, such as degradation behavior, the developed scaffolds are promising biomaterials for various tissue-engineering and wound-healing applications.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>32485817</pmid><doi>10.3390/polym12061233</doi><orcidid>https://orcid.org/0000-0003-3335-4561</orcidid><orcidid>https://orcid.org/0000-0002-7704-5608</orcidid><orcidid>https://orcid.org/0000-0002-3096-1131</orcidid><orcidid>https://orcid.org/0000-0002-4529-8731</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Antiinfectives and antibacterials Antimicrobial agents Ball milling Biomedical materials Bone marrow Composite materials Glycerol Identification and classification Microscopy Nanofibers Nanoparticles Oxygen Polyesters Polymers Properties Proteins Public health Scaffolds Stem cells Structure Surgical implants Tissue engineering Transplants & implants Wound healing |
| title | Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications |
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