Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis Molecular Bacterial Load Assay

In this comparative biomarker study, we analysed 1768 serial sputum samples from 178 patients at 4 sites in Southeast Africa. We show that tuberculosis Molecular Bacterial Load Assay (TB-MBLA) reduces time-to-TB-bacillary-load-result from days/weeks by culture to hours and detects early patient trea...

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Veröffentlicht in:	Thorax 2020-07, Vol.75 (7), p.606-608
Hauptverfasser:	Sabiiti, Wilber, Azam, Khalide, Farmer, Eoghan Charles William, Kuchaka, Davis, Mtafya, Bariki, Bowness, Ruth, Oravcova, Katarina, Honeyborne, Isobella, Evangelopoulos, Dimitrios, McHugh, Timothy Daniel, Khosa, Celso, Rachow, Andrea, Heinrich, Norbert, Kampira, Elizabeth, Davies, Geraint, Bhatt, Nilesh, Ntinginya, Elias N, Viegas, Sofia, Jani, Ilesh, Kamdolozi, Mercy, Mdolo, Aaron, Khonga, Margaret, Boeree, Martin J, Phillips, Patrick P J, Sloan, Derek, Hoelscher, Michael, Kibiki, Gibson, Gillespie, Stephen H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Antibiotics, Antitubercular - therapeutic use bacterial Infection Bacterial Load Biomarkers Biomarkers - metabolism Brief Communication Clinical outcomes Clinical trials Cost analysis Disease management Drug resistance Female Follow-Up Studies HIV Human immunodeficiency virus Humans Immunoassay Infections Male Medical personnel Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - isolation & purification Patients Prognosis respiratory infection Sputum - microbiology Tuberculosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - microbiology Variance analysis
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