Bone turnover markers in serum but not in saliva correlate with bone mineral density
Saliva was proposed as a diagnostic tool for systemic diseases. Here we determined the correlation of bone turnover markers in saliva, bone turnover markers in serum and bone mineral density in postmenopausal osteoporotic and healthy women. Forty postmenopausal osteoporotic and 40 age-matched health...
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| Veröffentlicht in: | Scientific reports 2020-07, Vol.10 (1), p.11550, Article 11550 |
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| description | Saliva was proposed as a diagnostic tool for systemic diseases. Here we determined the correlation of bone turnover markers in saliva, bone turnover markers in serum and bone mineral density in postmenopausal osteoporotic and healthy women. Forty postmenopausal osteoporotic and 40 age-matched healthy non-osteoporotic females were recruited for this case–control study. Serum and stimulated saliva levels of osteocalcin, N-terminal propeptide of type I collagen, bone-specific alkaline phosphatase and cross-linked-C-telopeptide of type I collagen were determined. Bone mineral density of the lumbar spine, proximal femur, and total hip were obtained. We show that osteocalcin and cross-linked-C-telopeptide of type I collagen (CTX) reached detectable levels in saliva while N-terminal propeptide of type I collagen and alkaline phosphatase were close or below the detection limit. Serum levels of bone turnover markers were significantly higher than saliva levels. Correlation analysis revealed a strong correlation of serum osteocalcin and, to a lesser extent, also serum CTX values with bone mineral density in lumbar spine, femoral neck, or total hip, respectively. There was, however, no significant correlation of bone mineral density with the respective bone turnover markers in saliva. There was a trend that saliva osteocalcin correlates with femoral neck (
p
= 0.16) or total hip (
p
= 0.06). There was also no association between serum and saliva bone turnover markers. This study reveals that saliva cannot replace the withdrawal of serum to evaluate bone metabolism. |
| doi_str_mv | 10.1038/s41598-020-68442-z |
| format | Article |
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p
= 0.16) or total hip (
p
= 0.06). There was also no association between serum and saliva bone turnover markers. This study reveals that saliva cannot replace the withdrawal of serum to evaluate bone metabolism.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-68442-z</identifier><identifier>PMID: 32665632</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743 ; 692/163/2743/316 ; 692/163/2743/316/801 ; 692/53/2422 ; 692/700/3032/3086 ; 692/700/3032/3139 ; Aged ; Alkaline phosphatase ; Biomarkers - metabolism ; Bone and Bones - physiology ; Bone Density ; Bone mineral density ; Bone Remodeling ; Bone turnover ; Case-Control Studies ; Collagen ; Collagen (type I) ; Collagen Type I - metabolism ; Correlation analysis ; Cross-Sectional Studies ; Female ; Femur ; Femur Neck - metabolism ; Health risk assessment ; Hip ; Humanities and Social Sciences ; Humans ; Kinetics ; Lumbar Vertebrae - metabolism ; Middle Aged ; multidisciplinary ; Osteocalcin ; Osteocalcin - blood ; Osteocalcin - metabolism ; Osteoporosis ; Osteoporosis, Postmenopausal - blood ; Osteoporosis, Postmenopausal - metabolism ; Outpatients ; Peptides - metabolism ; Phosphatase ; Post-menopause ; Prognosis ; Saliva ; Saliva - metabolism ; Science ; Science (multidisciplinary) ; Serum levels ; Spine ; Spine (lumbar)</subject><ispartof>Scientific reports, 2020-07, Vol.10 (1), p.11550, Article 11550</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-241405d93ca72e0d09f744204ffb2ff83676eb1c8fa22a97d5b4dfc5b903b1823</citedby><cites>FETCH-LOGICAL-c474t-241405d93ca72e0d09f744204ffb2ff83676eb1c8fa22a97d5b4dfc5b903b1823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360752/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360752/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32665632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kerschan-Schindl, Katharina</creatorcontrib><creatorcontrib>Boschitsch, Ewald</creatorcontrib><creatorcontrib>Marculescu, Rodrig</creatorcontrib><creatorcontrib>Gruber, Reinhard</creatorcontrib><creatorcontrib>Pietschmann, Peter</creatorcontrib><title>Bone turnover markers in serum but not in saliva correlate with bone mineral density</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Saliva was proposed as a diagnostic tool for systemic diseases. Here we determined the correlation of bone turnover markers in saliva, bone turnover markers in serum and bone mineral density in postmenopausal osteoporotic and healthy women. Forty postmenopausal osteoporotic and 40 age-matched healthy non-osteoporotic females were recruited for this case–control study. Serum and stimulated saliva levels of osteocalcin, N-terminal propeptide of type I collagen, bone-specific alkaline phosphatase and cross-linked-C-telopeptide of type I collagen were determined. Bone mineral density of the lumbar spine, proximal femur, and total hip were obtained. We show that osteocalcin and cross-linked-C-telopeptide of type I collagen (CTX) reached detectable levels in saliva while N-terminal propeptide of type I collagen and alkaline phosphatase were close or below the detection limit. Serum levels of bone turnover markers were significantly higher than saliva levels. Correlation analysis revealed a strong correlation of serum osteocalcin and, to a lesser extent, also serum CTX values with bone mineral density in lumbar spine, femoral neck, or total hip, respectively. There was, however, no significant correlation of bone mineral density with the respective bone turnover markers in saliva. There was a trend that saliva osteocalcin correlates with femoral neck (
p
= 0.16) or total hip (
p
= 0.06). There was also no association between serum and saliva bone turnover markers. This study reveals that saliva cannot replace the withdrawal of serum to evaluate bone metabolism.</description><subject>692/163/2743</subject><subject>692/163/2743/316</subject><subject>692/163/2743/316/801</subject><subject>692/53/2422</subject><subject>692/700/3032/3086</subject><subject>692/700/3032/3139</subject><subject>Aged</subject><subject>Alkaline phosphatase</subject><subject>Biomarkers - metabolism</subject><subject>Bone and Bones - physiology</subject><subject>Bone Density</subject><subject>Bone mineral density</subject><subject>Bone Remodeling</subject><subject>Bone turnover</subject><subject>Case-Control Studies</subject><subject>Collagen</subject><subject>Collagen (type I)</subject><subject>Collagen Type I - metabolism</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Femur</subject><subject>Femur Neck - metabolism</subject><subject>Health risk assessment</subject><subject>Hip</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Lumbar Vertebrae - 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metabolism</topic><topic>Bone and Bones - physiology</topic><topic>Bone Density</topic><topic>Bone mineral density</topic><topic>Bone Remodeling</topic><topic>Bone turnover</topic><topic>Case-Control Studies</topic><topic>Collagen</topic><topic>Collagen (type I)</topic><topic>Collagen Type I - metabolism</topic><topic>Correlation analysis</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Femur</topic><topic>Femur Neck - metabolism</topic><topic>Health risk assessment</topic><topic>Hip</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Lumbar Vertebrae - metabolism</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Osteocalcin</topic><topic>Osteocalcin - blood</topic><topic>Osteocalcin - metabolism</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - blood</topic><topic>Osteoporosis, Postmenopausal - metabolism</topic><topic>Outpatients</topic><topic>Peptides - metabolism</topic><topic>Phosphatase</topic><topic>Post-menopause</topic><topic>Prognosis</topic><topic>Saliva</topic><topic>Saliva - metabolism</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Serum levels</topic><topic>Spine</topic><topic>Spine (lumbar)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kerschan-Schindl, Katharina</creatorcontrib><creatorcontrib>Boschitsch, Ewald</creatorcontrib><creatorcontrib>Marculescu, Rodrig</creatorcontrib><creatorcontrib>Gruber, Reinhard</creatorcontrib><creatorcontrib>Pietschmann, Peter</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kerschan-Schindl, Katharina</au><au>Boschitsch, Ewald</au><au>Marculescu, Rodrig</au><au>Gruber, Reinhard</au><au>Pietschmann, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone turnover markers in serum but not in saliva correlate with bone mineral density</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-07-14</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>11550</spage><pages>11550-</pages><artnum>11550</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Saliva was proposed as a diagnostic tool for systemic diseases. Here we determined the correlation of bone turnover markers in saliva, bone turnover markers in serum and bone mineral density in postmenopausal osteoporotic and healthy women. Forty postmenopausal osteoporotic and 40 age-matched healthy non-osteoporotic females were recruited for this case–control study. Serum and stimulated saliva levels of osteocalcin, N-terminal propeptide of type I collagen, bone-specific alkaline phosphatase and cross-linked-C-telopeptide of type I collagen were determined. Bone mineral density of the lumbar spine, proximal femur, and total hip were obtained. We show that osteocalcin and cross-linked-C-telopeptide of type I collagen (CTX) reached detectable levels in saliva while N-terminal propeptide of type I collagen and alkaline phosphatase were close or below the detection limit. Serum levels of bone turnover markers were significantly higher than saliva levels. Correlation analysis revealed a strong correlation of serum osteocalcin and, to a lesser extent, also serum CTX values with bone mineral density in lumbar spine, femoral neck, or total hip, respectively. There was, however, no significant correlation of bone mineral density with the respective bone turnover markers in saliva. There was a trend that saliva osteocalcin correlates with femoral neck (
p
= 0.16) or total hip (
p
= 0.06). There was also no association between serum and saliva bone turnover markers. This study reveals that saliva cannot replace the withdrawal of serum to evaluate bone metabolism.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32665632</pmid><doi>10.1038/s41598-020-68442-z</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 692/163/2743 692/163/2743/316 692/163/2743/316/801 692/53/2422 692/700/3032/3086 692/700/3032/3139 Aged Alkaline phosphatase Biomarkers - metabolism Bone and Bones - physiology Bone Density Bone mineral density Bone Remodeling Bone turnover Case-Control Studies Collagen Collagen (type I) Collagen Type I - metabolism Correlation analysis Cross-Sectional Studies Female Femur Femur Neck - metabolism Health risk assessment Hip Humanities and Social Sciences Humans Kinetics Lumbar Vertebrae - metabolism Middle Aged multidisciplinary Osteocalcin Osteocalcin - blood Osteocalcin - metabolism Osteoporosis Osteoporosis, Postmenopausal - blood Osteoporosis, Postmenopausal - metabolism Outpatients Peptides - metabolism Phosphatase Post-menopause Prognosis Saliva Saliva - metabolism Science Science (multidisciplinary) Serum levels Spine Spine (lumbar) |
| title | Bone turnover markers in serum but not in saliva correlate with bone mineral density |
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