Kinome profiling of peripheral blood mononuclear cells collected prior to vaccination reveals biomarkers and potential mechanisms of vaccine unresponsiveness in pigs

Inter-individual variance in host immune responses following vaccination can result in failure to develop protective immunity leaving individuals at risk for infection in addition to compromising herd immunity. While developing more efficacious vaccines is one strategy to mitigate this problem, pred...

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Veröffentlicht in:	Scientific reports 2020-07, Vol.10 (1), p.11546-11546, Article 11546
Hauptverfasser:	Lipsit, Sean W. L., Wilkinson, James, Scruten, Erin, Facciuolo, Antonio, Denomy, Connor, Griebel, Philip J., Kusalik, Anthony, Plastow, Graham, Napper, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/590 692/53/2423 Animals Animals, Newborn Antibodies, Bacterial - blood Bacterial Vaccines - immunology Biomarkers Biomarkers - metabolism Body weight Cytokines Cytokines - blood Female Herd immunity Humanities and Social Sciences Immune response Immunoglobulin G - blood Inflammation Interferon-gamma - blood Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Male multidisciplinary Mycoplasma hyopneumoniae Peptides Peripheral blood mononuclear cells Phosphorylation Pneumonia of Swine, Mycoplasmal - immunology Pneumonia of Swine, Mycoplasmal - prevention & control Science Science (multidisciplinary) Signal Transduction Swine Transcription, Genetic Vaccination - veterinary Vaccines γ-Interferon
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