ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals

Neurons face unique transport challenges. They need to deliver cargo over long axonal distances and to many presynaptic nerve terminals. Rab GTPases are master regulators of vesicular traffic, but essential presynaptic Rabs have not been identified. Here, we find that Rab6, a Golgi-derived GTPase fo...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-06, Vol.31 (10), p.107712-107712, Article 107712
Hauptverfasser:	Nyitrai, Hajnalka, Wang, Shan Shan H., Kaeser, Pascal S.
Format:	Artikel
Sprache:	eng
Schlagworte:	active zone Animals axonal traffic cargo capture CAST ELKS1 Erc1 Golgin HEK293 Cells Humans Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - metabolism Neurons - metabolism Presynaptic Terminals - metabolism rab GTP-Binding Proteins - metabolism Rab6 Rab6IP2 synaptic vesicle
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