Sclerostin Antibody Treatment Rescues the Osteopenic Bone Phenotype of TGFß Inducible Early Gene-1 Knockout Female Mice

Deletion of TGFβ Inducible Early Gene-1 (TIEG) in mice results in an osteopenic phenotype which exists only in female animals. Molecular analyses on female TIEG knockout (KO) mouse bones identified increased expression of sclerostin, an effect that was confirmed at the protein level in serum. Sclero...

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Veröffentlicht in:	Journal of cellular physiology 2020-01, Vol.235 (7-8), p.5679-5688
Hauptverfasser:	Gingery, Anne, Subramaniam, Malayannan, Pitel, Kevin S., Li, Xiaodong, Ke, Hua Z., Turner, Russell T., Iwaniec, Urszula T., Hawse, John R.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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