Evaluation of the New American Joint Committee on Cancer Staging Manual 8th Edition for Perihilar Cholangiocarcinoma
Background The aim was to compare the prognostic accuracy of cross-sectional imaging of the 7th and 8th editions of the American Joint Committee on Cancer(AJCC) staging system for perihilar cholangiocarcinoma(PHC). Methods All patients with PHC between 2002 and 2014 were included. Imaging at the tim...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2020-07, Vol.24 (7), p.1612-1618 |
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| creator | Gaspersz, Marcia P. Buettner, Stefan van Vugt, Jeroen L. A. de Jonge, Jeroen Polak, Wojciech G. Doukas, Michail Ijzermans, Jan N. M. Koerkamp, Bas Groot Willemssen, François E. J. A. |
| description | Background
The aim was to compare the prognostic accuracy of cross-sectional imaging of the 7th and 8th editions of the American Joint Committee on Cancer(AJCC) staging system for perihilar cholangiocarcinoma(PHC).
Methods
All patients with PHC between 2002 and 2014 were included. Imaging at the time of presentation was reassessed and clinical tumor–node–metastasis (cTNM) stage was determined according to the 7th and 8th editions of the AJCC staging system. Comparison of the prognostic accuracy was performed using the concordance index (c-index).
Results
A total of 248 PHC patients were included;45 patients(18.1%) underwent a curative-intent resection, whereas 203 patients(81.9%) did not because they were unfit for surgery or were diagnosed with locally advanced or metastatic disease during workup. Prognostic accuracy was comparable between the 7th and 8th editions (c-index 0.57 vs 0.58). For patients who underwent a curative-intent resection, the prognostic accuracy of the 8th edition (0.67) was higher than the 7th (0.65). For patients who did not undergo a curative-intent resection, the prognostic accuracy was poor in both the 7th as the 8th editions (0.54 vs 0.57).
Conclusion
The 7th and 8th editions of the AJCC staging system for PHC have comparable prognostic accuracy. Prognostic accuracy was particularly poor in unresectable patients. |
| doi_str_mv | 10.1007/s11605-019-04127-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7359130</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2178842368</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-a80ee5fc9693e571341ff2bb264c77508017b25f817029df2a60530ac1f833233</originalsourceid><addsrcrecordid>eNp9kUtv1TAQhS0EoqXwB1ggS2zYBPyIY2eDVEWXl8pDAiR21lxfO3GV2K3tlPLvcXtLeSxYjaX55swcH4QeU_KcEiJfZEo7IhpC-4a0lMnm8g46pErypu1Yd7e-SU8bJsS3A_Qg51NCqCRU3UcHnEjRcdoeorK5gHmF4mPA0eEyWfzBfsfHi03eQMDvog8FD3FZfCnW4ooNEIxN-HOB0YcRv4ewwoxVmfBm56-FXEz4UxWY_AwJD1OcIYw-GkjGh7jAQ3TPwZzto5t6hL6-2nwZ3jQnH1-_HY5PGiNaUhpQxFrhTN_13ApJeUudY9st61ojpSCq-tky4VS1xfqdY1C_gxMw1CnOGedH6OVe92zdLnZnbCgJZn2W_ALph47g9d-d4Cc9xgstuegpJ1Xg2Y1AiuerzUUvPhs7Vz82rlkzxnpSz2uv0Kf_oKdxTaHa04xKpVrGO1UptqdMijkn626PoURfhar3oeoaqr4OVV_WoSd_2rgd-ZViBfgeyLUVRpt-7_6P7E_0va3l</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2178842368</pqid></control><display><type>article</type><title>Evaluation of the New American Joint Committee on Cancer Staging Manual 8th Edition for Perihilar Cholangiocarcinoma</title><source>MEDLINE</source><source>SpringerNature Complete Journals</source><creator>Gaspersz, Marcia P. ; Buettner, Stefan ; van Vugt, Jeroen L. A. ; de Jonge, Jeroen ; Polak, Wojciech G. ; Doukas, Michail ; Ijzermans, Jan N. M. ; Koerkamp, Bas Groot ; Willemssen, François E. J. A.</creator><creatorcontrib>Gaspersz, Marcia P. ; Buettner, Stefan ; van Vugt, Jeroen L. A. ; de Jonge, Jeroen ; Polak, Wojciech G. ; Doukas, Michail ; Ijzermans, Jan N. M. ; Koerkamp, Bas Groot ; Willemssen, François E. J. A.</creatorcontrib><description>Background
The aim was to compare the prognostic accuracy of cross-sectional imaging of the 7th and 8th editions of the American Joint Committee on Cancer(AJCC) staging system for perihilar cholangiocarcinoma(PHC).
Methods
All patients with PHC between 2002 and 2014 were included. Imaging at the time of presentation was reassessed and clinical tumor–node–metastasis (cTNM) stage was determined according to the 7th and 8th editions of the AJCC staging system. Comparison of the prognostic accuracy was performed using the concordance index (c-index).
Results
A total of 248 PHC patients were included;45 patients(18.1%) underwent a curative-intent resection, whereas 203 patients(81.9%) did not because they were unfit for surgery or were diagnosed with locally advanced or metastatic disease during workup. Prognostic accuracy was comparable between the 7th and 8th editions (c-index 0.57 vs 0.58). For patients who underwent a curative-intent resection, the prognostic accuracy of the 8th edition (0.67) was higher than the 7th (0.65). For patients who did not undergo a curative-intent resection, the prognostic accuracy was poor in both the 7th as the 8th editions (0.54 vs 0.57).
Conclusion
The 7th and 8th editions of the AJCC staging system for PHC have comparable prognostic accuracy. Prognostic accuracy was particularly poor in unresectable patients.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-019-04127-x</identifier><identifier>PMID: 30756314</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Accuracy ; Bile Duct Neoplasms - pathology ; Bile Duct Neoplasms - surgery ; Cancer ; Cholangiocarcinoma ; Comparative studies ; Gastroenterology ; Gastrointestinal surgery ; Humans ; Klatskin Tumor - surgery ; Medical prognosis ; Medicine ; Medicine & Public Health ; Neoplasm Staging ; Original ; Original Article ; Prognosis ; Surgery ; United States</subject><ispartof>Journal of gastrointestinal surgery, 2020-07, Vol.24 (7), p.1612-1618</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-a80ee5fc9693e571341ff2bb264c77508017b25f817029df2a60530ac1f833233</citedby><cites>FETCH-LOGICAL-c540t-a80ee5fc9693e571341ff2bb264c77508017b25f817029df2a60530ac1f833233</cites><orcidid>0000-0003-2729-7222</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-019-04127-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-019-04127-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30756314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaspersz, Marcia P.</creatorcontrib><creatorcontrib>Buettner, Stefan</creatorcontrib><creatorcontrib>van Vugt, Jeroen L. A.</creatorcontrib><creatorcontrib>de Jonge, Jeroen</creatorcontrib><creatorcontrib>Polak, Wojciech G.</creatorcontrib><creatorcontrib>Doukas, Michail</creatorcontrib><creatorcontrib>Ijzermans, Jan N. M.</creatorcontrib><creatorcontrib>Koerkamp, Bas Groot</creatorcontrib><creatorcontrib>Willemssen, François E. J. A.</creatorcontrib><title>Evaluation of the New American Joint Committee on Cancer Staging Manual 8th Edition for Perihilar Cholangiocarcinoma</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Background
The aim was to compare the prognostic accuracy of cross-sectional imaging of the 7th and 8th editions of the American Joint Committee on Cancer(AJCC) staging system for perihilar cholangiocarcinoma(PHC).
Methods
All patients with PHC between 2002 and 2014 were included. Imaging at the time of presentation was reassessed and clinical tumor–node–metastasis (cTNM) stage was determined according to the 7th and 8th editions of the AJCC staging system. Comparison of the prognostic accuracy was performed using the concordance index (c-index).
Results
A total of 248 PHC patients were included;45 patients(18.1%) underwent a curative-intent resection, whereas 203 patients(81.9%) did not because they were unfit for surgery or were diagnosed with locally advanced or metastatic disease during workup. Prognostic accuracy was comparable between the 7th and 8th editions (c-index 0.57 vs 0.58). For patients who underwent a curative-intent resection, the prognostic accuracy of the 8th edition (0.67) was higher than the 7th (0.65). For patients who did not undergo a curative-intent resection, the prognostic accuracy was poor in both the 7th as the 8th editions (0.54 vs 0.57).
Conclusion
The 7th and 8th editions of the AJCC staging system for PHC have comparable prognostic accuracy. Prognostic accuracy was particularly poor in unresectable patients.</description><subject>Accuracy</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Cancer</subject><subject>Cholangiocarcinoma</subject><subject>Comparative studies</subject><subject>Gastroenterology</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Klatskin Tumor - surgery</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Staging</subject><subject>Original</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Surgery</subject><subject>United States</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtv1TAQhS0EoqXwB1ggS2zYBPyIY2eDVEWXl8pDAiR21lxfO3GV2K3tlPLvcXtLeSxYjaX55swcH4QeU_KcEiJfZEo7IhpC-4a0lMnm8g46pErypu1Yd7e-SU8bJsS3A_Qg51NCqCRU3UcHnEjRcdoeorK5gHmF4mPA0eEyWfzBfsfHi03eQMDvog8FD3FZfCnW4ooNEIxN-HOB0YcRv4ewwoxVmfBm56-FXEz4UxWY_AwJD1OcIYw-GkjGh7jAQ3TPwZzto5t6hL6-2nwZ3jQnH1-_HY5PGiNaUhpQxFrhTN_13ApJeUudY9st61ojpSCq-tky4VS1xfqdY1C_gxMw1CnOGedH6OVe92zdLnZnbCgJZn2W_ALph47g9d-d4Cc9xgstuegpJ1Xg2Y1AiuerzUUvPhs7Vz82rlkzxnpSz2uv0Kf_oKdxTaHa04xKpVrGO1UptqdMijkn626PoURfhar3oeoaqr4OVV_WoSd_2rgd-ZViBfgeyLUVRpt-7_6P7E_0va3l</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Gaspersz, Marcia P.</creator><creator>Buettner, Stefan</creator><creator>van Vugt, Jeroen L. A.</creator><creator>de Jonge, Jeroen</creator><creator>Polak, Wojciech G.</creator><creator>Doukas, Michail</creator><creator>Ijzermans, Jan N. M.</creator><creator>Koerkamp, Bas Groot</creator><creator>Willemssen, François E. J. A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2729-7222</orcidid></search><sort><creationdate>20200701</creationdate><title>Evaluation of the New American Joint Committee on Cancer Staging Manual 8th Edition for Perihilar Cholangiocarcinoma</title><author>Gaspersz, Marcia P. ; Buettner, Stefan ; van Vugt, Jeroen L. A. ; de Jonge, Jeroen ; Polak, Wojciech G. ; Doukas, Michail ; Ijzermans, Jan N. M. ; Koerkamp, Bas Groot ; Willemssen, François E. J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-a80ee5fc9693e571341ff2bb264c77508017b25f817029df2a60530ac1f833233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Accuracy</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Duct Neoplasms - surgery</topic><topic>Cancer</topic><topic>Cholangiocarcinoma</topic><topic>Comparative studies</topic><topic>Gastroenterology</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Klatskin Tumor - surgery</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Staging</topic><topic>Original</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Surgery</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaspersz, Marcia P.</creatorcontrib><creatorcontrib>Buettner, Stefan</creatorcontrib><creatorcontrib>van Vugt, Jeroen L. 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A.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaspersz, Marcia P.</au><au>Buettner, Stefan</au><au>van Vugt, Jeroen L. A.</au><au>de Jonge, Jeroen</au><au>Polak, Wojciech G.</au><au>Doukas, Michail</au><au>Ijzermans, Jan N. M.</au><au>Koerkamp, Bas Groot</au><au>Willemssen, François E. J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the New American Joint Committee on Cancer Staging Manual 8th Edition for Perihilar Cholangiocarcinoma</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>24</volume><issue>7</issue><spage>1612</spage><epage>1618</epage><pages>1612-1618</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Background
The aim was to compare the prognostic accuracy of cross-sectional imaging of the 7th and 8th editions of the American Joint Committee on Cancer(AJCC) staging system for perihilar cholangiocarcinoma(PHC).
Methods
All patients with PHC between 2002 and 2014 were included. Imaging at the time of presentation was reassessed and clinical tumor–node–metastasis (cTNM) stage was determined according to the 7th and 8th editions of the AJCC staging system. Comparison of the prognostic accuracy was performed using the concordance index (c-index).
Results
A total of 248 PHC patients were included;45 patients(18.1%) underwent a curative-intent resection, whereas 203 patients(81.9%) did not because they were unfit for surgery or were diagnosed with locally advanced or metastatic disease during workup. Prognostic accuracy was comparable between the 7th and 8th editions (c-index 0.57 vs 0.58). For patients who underwent a curative-intent resection, the prognostic accuracy of the 8th edition (0.67) was higher than the 7th (0.65). For patients who did not undergo a curative-intent resection, the prognostic accuracy was poor in both the 7th as the 8th editions (0.54 vs 0.57).
Conclusion
The 7th and 8th editions of the AJCC staging system for PHC have comparable prognostic accuracy. Prognostic accuracy was particularly poor in unresectable patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30756314</pmid><doi>10.1007/s11605-019-04127-x</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2729-7222</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Accuracy Bile Duct Neoplasms - pathology Bile Duct Neoplasms - surgery Cancer Cholangiocarcinoma Comparative studies Gastroenterology Gastrointestinal surgery Humans Klatskin Tumor - surgery Medical prognosis Medicine Medicine & Public Health Neoplasm Staging Original Original Article Prognosis Surgery United States |
| title | Evaluation of the New American Joint Committee on Cancer Staging Manual 8th Edition for Perihilar Cholangiocarcinoma |
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