Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis

Loss of iron-sulfur cluster function predisposes cancer cells to ferroptosis by upregulating iron-starvation response, but the role of glutaredoxin 5 (GLRX5) silencing in ferroptosis remains unknown. We examined the role of GLRX5 functional loss in promoting ferroptosis in cisplatin-resistant head a...

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Veröffentlicht in:	Theranostics 2020-01, Vol.10 (17), p.7775-7786
Hauptverfasser:	Lee, Jaewang, You, Ji Hyeon, Shin, Daiha, Roh, Jong-Lyel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Biosynthesis Cell Line, Tumor Chemotherapy Cisplatin - pharmacology Cisplatin - therapeutic use Cloning Cysts Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Ferroptosis Ferroptosis - drug effects Glutaredoxins - antagonists & inhibitors Glutaredoxins - genetics Glutaredoxins - metabolism Head & neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - pathology Humans Iron Iron - metabolism Lipid peroxidation Lipids Male Mice Mitochondria - drug effects Mitochondria - pathology Mutation Plasmids Proteins Reactive oxygen species Research Paper RNA Interference Sulfasalazine - pharmacology Sulfasalazine - therapeutic use Xenograft Model Antitumor Assays
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