Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing
•The composite filaments were successfully developed via melt-blending technique.•AMP-PEEK filaments can serve as feedstock for 3D printing of patient-specific implants.•The bioactivity of the composites significantly increased cell adhesion and proliferation.•AMP-PEEK facilitate in vivo osseointegr...
Gespeichert in:
| Veröffentlicht in: | Dental materials 2020-07, Vol.36 (7), p.865-883 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 883 |
|---|---|
| container_issue | 7 |
| container_start_page | 865 |
| container_title | Dental materials |
| container_volume | 36 |
| creator | Sikder, Prabaha Ferreira, Jessica A. Fakhrabadi, Ehsan Akbari Kantorski, Karla Z. Liberatore, Matthew W. Bottino, Marco C. Bhaduri, Sarit B. |
| description | •The composite filaments were successfully developed via melt-blending technique.•AMP-PEEK filaments can serve as feedstock for 3D printing of patient-specific implants.•The bioactivity of the composites significantly increased cell adhesion and proliferation.•AMP-PEEK facilitate in vivo osseointegration and suitable bone regeneration capabilities.
The aim of this study was to develop bioactive and osseointegrable polyetheretherketone (PEEK)-based composite filaments melt-blended with novel amorphous magnesium phosphate (AMP) particles for 3D printing of dental and orthopedic implants.
A series of materials and biological analyses of AMP-PEEK were performed. Thermal stability, thermogravimetric and differential scanning calorimetry curves of as-synthesized AMP were measured. Complex viscosity, elastic modulus and viscous modulus were determined using a rotational rheometer. In vitro bioactivity was analyzed using SBF immersion method. SEM, EDS and XRD were used to study the apatite-forming ability of the AMP-PEEK filaments. Mouse pre-osteoblasts (MC3T3-E1) were cultured and analyzed for cell viability, proliferation and gene expression. For in vivo analyses, bare PEEK was used as the control and 15AMP-PEEK was chosen based on its in vitro cell-related results. After 4 or 12 weeks, animals were euthanized, and the femurs were collected for micro-computed tomography (μ-CT) and histology.
The collected findings confirmed the homogeneous dispersion of AMP particles within the PEEK matrix with no phase degradation. Rheological studies demonstrated that AMP-PEEK composites are good candidates for 3D printing by exhibiting high zero-shear and low infinite-shear viscosities. In vitro results revealed enhanced bioactivity and superior pre-osteoblast cell function in the case of AMP-PEEK composites as compared to bare PEEK. In vivo analyses further corroborated the enhanced osseointegration capacity for AMP-PEEK implants.
Collectively, the present investigation demonstrated that AMP-PEEK composite filaments can serve as feedstock for 3D printing of orthopedic and dental implants due to enhanced bioactivity and osseointegration capacity. |
| doi_str_mv | 10.1016/j.dental.2020.04.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7359049</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0109564120301056</els_id><sourcerecordid>2438721486</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-21b364ec7aecc872fce8bb786e3f3c1a9960035ce84630143bd95d44420872cc3</originalsourceid><addsrcrecordid>eNp9UU1v1DAQtRCILoV_gFAkLlwSxh_58AWJlk-pUi9wNo4z2fWS2MF2Vuq_r9sthXLg4pE9b57fm0fISwoVBdq83VcDuqSnigGDCkQF0D0iG9q1sgSQ7WOyAQqyrBtBT8izGPcAIJikT8kJZ6KmDLoN-XFmvTbJHrDQsw_Lzq-xmPXWYbTrXOR7XHY6Ybn46QrTDsPt8ROTd1gYPy8-2oTFaCc9Zz2xGH0o-IdiCdYl67bPyZNRTxFf3NVT8v3Tx2_nX8qLy89fz99flEZImkpGe94INK1GY7qWjQa7vm-7BvnIDdVSNgC8zq-i4UAF7wdZD0KI7KJlxvBT8u7Iu6z9jIPJWoKeVJYx63ClvLbqYcfZndr6g2p5LUHITPDmjiD4XyvGpGYbDU6TdpiXopiARtZMsDZDX_8D3fs1uGwvo3jWQ0XXZJQ4okzwMQYc78VQUDcRqr06RqhuIlQgVI4wj73628j90O_M_jjFvM6DxaCisegMDjagSWrw9v8_XAPaQrFf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2438721486</pqid></control><display><type>article</type><title>Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Sikder, Prabaha ; Ferreira, Jessica A. ; Fakhrabadi, Ehsan Akbari ; Kantorski, Karla Z. ; Liberatore, Matthew W. ; Bottino, Marco C. ; Bhaduri, Sarit B.</creator><creatorcontrib>Sikder, Prabaha ; Ferreira, Jessica A. ; Fakhrabadi, Ehsan Akbari ; Kantorski, Karla Z. ; Liberatore, Matthew W. ; Bottino, Marco C. ; Bhaduri, Sarit B.</creatorcontrib><description>•The composite filaments were successfully developed via melt-blending technique.•AMP-PEEK filaments can serve as feedstock for 3D printing of patient-specific implants.•The bioactivity of the composites significantly increased cell adhesion and proliferation.•AMP-PEEK facilitate in vivo osseointegration and suitable bone regeneration capabilities.
The aim of this study was to develop bioactive and osseointegrable polyetheretherketone (PEEK)-based composite filaments melt-blended with novel amorphous magnesium phosphate (AMP) particles for 3D printing of dental and orthopedic implants.
A series of materials and biological analyses of AMP-PEEK were performed. Thermal stability, thermogravimetric and differential scanning calorimetry curves of as-synthesized AMP were measured. Complex viscosity, elastic modulus and viscous modulus were determined using a rotational rheometer. In vitro bioactivity was analyzed using SBF immersion method. SEM, EDS and XRD were used to study the apatite-forming ability of the AMP-PEEK filaments. Mouse pre-osteoblasts (MC3T3-E1) were cultured and analyzed for cell viability, proliferation and gene expression. For in vivo analyses, bare PEEK was used as the control and 15AMP-PEEK was chosen based on its in vitro cell-related results. After 4 or 12 weeks, animals were euthanized, and the femurs were collected for micro-computed tomography (μ-CT) and histology.
The collected findings confirmed the homogeneous dispersion of AMP particles within the PEEK matrix with no phase degradation. Rheological studies demonstrated that AMP-PEEK composites are good candidates for 3D printing by exhibiting high zero-shear and low infinite-shear viscosities. In vitro results revealed enhanced bioactivity and superior pre-osteoblast cell function in the case of AMP-PEEK composites as compared to bare PEEK. In vivo analyses further corroborated the enhanced osseointegration capacity for AMP-PEEK implants.
Collectively, the present investigation demonstrated that AMP-PEEK composite filaments can serve as feedstock for 3D printing of orthopedic and dental implants due to enhanced bioactivity and osseointegration capacity.</description><identifier>ISSN: 0109-5641</identifier><identifier>EISSN: 1879-0097</identifier><identifier>DOI: 10.1016/j.dental.2020.04.008</identifier><identifier>PMID: 32451208</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>3-D printers ; 3D printing ; Amorphous magnesium phosphate ; AMP ; Animals ; Apatite ; Benzophenones ; Biological activity ; Biological analysis ; Biomedical materials ; Calorimetry ; Cell viability ; Computed tomography ; Dental Implants ; Dental materials ; Dental prosthetics ; Dental restorative materials ; Differential scanning calorimetry ; Filaments ; Gene expression ; Histology ; Implants ; Ketones ; Magnesium ; Magnesium Compounds ; Magnesium phosphate ; Mechanical properties ; Mice ; Modulus of elasticity ; Orthopaedic implants ; Orthopedics ; Osseointegration ; Osteoblasts ; Phosphates ; Polyether ether ketones ; Polyetheretherketone ; Polyethylene Glycols ; Polymer matrix composites ; Polymers ; Printing ; Printing, Three-Dimensional ; Rheological properties ; Stability analysis ; Submerging ; Surgical implants ; Thermal stability ; Thermogravimetric analysis ; Three dimensional composites ; Three dimensional printing ; X-Ray Microtomography</subject><ispartof>Dental materials, 2020-07, Vol.36 (7), p.865-883</ispartof><rights>2020 The Academy of Dental Materials</rights><rights>Copyright © 2020 The Academy of Dental Materials. All rights reserved.</rights><rights>Copyright Elsevier BV Jul 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-21b364ec7aecc872fce8bb786e3f3c1a9960035ce84630143bd95d44420872cc3</citedby><cites>FETCH-LOGICAL-c491t-21b364ec7aecc872fce8bb786e3f3c1a9960035ce84630143bd95d44420872cc3</cites><orcidid>0000-0001-6910-4199 ; 0000-0001-9302-2310 ; 0000-0002-6219-0255 ; 0000-0001-8740-2464 ; 0000-0002-5495-7145</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dental.2020.04.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32451208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sikder, Prabaha</creatorcontrib><creatorcontrib>Ferreira, Jessica A.</creatorcontrib><creatorcontrib>Fakhrabadi, Ehsan Akbari</creatorcontrib><creatorcontrib>Kantorski, Karla Z.</creatorcontrib><creatorcontrib>Liberatore, Matthew W.</creatorcontrib><creatorcontrib>Bottino, Marco C.</creatorcontrib><creatorcontrib>Bhaduri, Sarit B.</creatorcontrib><title>Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing</title><title>Dental materials</title><addtitle>Dent Mater</addtitle><description>•The composite filaments were successfully developed via melt-blending technique.•AMP-PEEK filaments can serve as feedstock for 3D printing of patient-specific implants.•The bioactivity of the composites significantly increased cell adhesion and proliferation.•AMP-PEEK facilitate in vivo osseointegration and suitable bone regeneration capabilities.
The aim of this study was to develop bioactive and osseointegrable polyetheretherketone (PEEK)-based composite filaments melt-blended with novel amorphous magnesium phosphate (AMP) particles for 3D printing of dental and orthopedic implants.
A series of materials and biological analyses of AMP-PEEK were performed. Thermal stability, thermogravimetric and differential scanning calorimetry curves of as-synthesized AMP were measured. Complex viscosity, elastic modulus and viscous modulus were determined using a rotational rheometer. In vitro bioactivity was analyzed using SBF immersion method. SEM, EDS and XRD were used to study the apatite-forming ability of the AMP-PEEK filaments. Mouse pre-osteoblasts (MC3T3-E1) were cultured and analyzed for cell viability, proliferation and gene expression. For in vivo analyses, bare PEEK was used as the control and 15AMP-PEEK was chosen based on its in vitro cell-related results. After 4 or 12 weeks, animals were euthanized, and the femurs were collected for micro-computed tomography (μ-CT) and histology.
The collected findings confirmed the homogeneous dispersion of AMP particles within the PEEK matrix with no phase degradation. Rheological studies demonstrated that AMP-PEEK composites are good candidates for 3D printing by exhibiting high zero-shear and low infinite-shear viscosities. In vitro results revealed enhanced bioactivity and superior pre-osteoblast cell function in the case of AMP-PEEK composites as compared to bare PEEK. In vivo analyses further corroborated the enhanced osseointegration capacity for AMP-PEEK implants.
Collectively, the present investigation demonstrated that AMP-PEEK composite filaments can serve as feedstock for 3D printing of orthopedic and dental implants due to enhanced bioactivity and osseointegration capacity.</description><subject>3-D printers</subject><subject>3D printing</subject><subject>Amorphous magnesium phosphate</subject><subject>AMP</subject><subject>Animals</subject><subject>Apatite</subject><subject>Benzophenones</subject><subject>Biological activity</subject><subject>Biological analysis</subject><subject>Biomedical materials</subject><subject>Calorimetry</subject><subject>Cell viability</subject><subject>Computed tomography</subject><subject>Dental Implants</subject><subject>Dental materials</subject><subject>Dental prosthetics</subject><subject>Dental restorative materials</subject><subject>Differential scanning calorimetry</subject><subject>Filaments</subject><subject>Gene expression</subject><subject>Histology</subject><subject>Implants</subject><subject>Ketones</subject><subject>Magnesium</subject><subject>Magnesium Compounds</subject><subject>Magnesium phosphate</subject><subject>Mechanical properties</subject><subject>Mice</subject><subject>Modulus of elasticity</subject><subject>Orthopaedic implants</subject><subject>Orthopedics</subject><subject>Osseointegration</subject><subject>Osteoblasts</subject><subject>Phosphates</subject><subject>Polyether ether ketones</subject><subject>Polyetheretherketone</subject><subject>Polyethylene Glycols</subject><subject>Polymer matrix composites</subject><subject>Polymers</subject><subject>Printing</subject><subject>Printing, Three-Dimensional</subject><subject>Rheological properties</subject><subject>Stability analysis</subject><subject>Submerging</subject><subject>Surgical implants</subject><subject>Thermal stability</subject><subject>Thermogravimetric analysis</subject><subject>Three dimensional composites</subject><subject>Three dimensional printing</subject><subject>X-Ray Microtomography</subject><issn>0109-5641</issn><issn>1879-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRCILoV_gFAkLlwSxh_58AWJlk-pUi9wNo4z2fWS2MF2Vuq_r9sthXLg4pE9b57fm0fISwoVBdq83VcDuqSnigGDCkQF0D0iG9q1sgSQ7WOyAQqyrBtBT8izGPcAIJikT8kJZ6KmDLoN-XFmvTbJHrDQsw_Lzq-xmPXWYbTrXOR7XHY6Ybn46QrTDsPt8ROTd1gYPy8-2oTFaCc9Zz2xGH0o-IdiCdYl67bPyZNRTxFf3NVT8v3Tx2_nX8qLy89fz99flEZImkpGe94INK1GY7qWjQa7vm-7BvnIDdVSNgC8zq-i4UAF7wdZD0KI7KJlxvBT8u7Iu6z9jIPJWoKeVJYx63ClvLbqYcfZndr6g2p5LUHITPDmjiD4XyvGpGYbDU6TdpiXopiARtZMsDZDX_8D3fs1uGwvo3jWQ0XXZJQ4okzwMQYc78VQUDcRqr06RqhuIlQgVI4wj73628j90O_M_jjFvM6DxaCisegMDjagSWrw9v8_XAPaQrFf</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Sikder, Prabaha</creator><creator>Ferreira, Jessica A.</creator><creator>Fakhrabadi, Ehsan Akbari</creator><creator>Kantorski, Karla Z.</creator><creator>Liberatore, Matthew W.</creator><creator>Bottino, Marco C.</creator><creator>Bhaduri, Sarit B.</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6910-4199</orcidid><orcidid>https://orcid.org/0000-0001-9302-2310</orcidid><orcidid>https://orcid.org/0000-0002-6219-0255</orcidid><orcidid>https://orcid.org/0000-0001-8740-2464</orcidid><orcidid>https://orcid.org/0000-0002-5495-7145</orcidid></search><sort><creationdate>20200701</creationdate><title>Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing</title><author>Sikder, Prabaha ; Ferreira, Jessica A. ; Fakhrabadi, Ehsan Akbari ; Kantorski, Karla Z. ; Liberatore, Matthew W. ; Bottino, Marco C. ; Bhaduri, Sarit B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-21b364ec7aecc872fce8bb786e3f3c1a9960035ce84630143bd95d44420872cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>3-D printers</topic><topic>3D printing</topic><topic>Amorphous magnesium phosphate</topic><topic>AMP</topic><topic>Animals</topic><topic>Apatite</topic><topic>Benzophenones</topic><topic>Biological activity</topic><topic>Biological analysis</topic><topic>Biomedical materials</topic><topic>Calorimetry</topic><topic>Cell viability</topic><topic>Computed tomography</topic><topic>Dental Implants</topic><topic>Dental materials</topic><topic>Dental prosthetics</topic><topic>Dental restorative materials</topic><topic>Differential scanning calorimetry</topic><topic>Filaments</topic><topic>Gene expression</topic><topic>Histology</topic><topic>Implants</topic><topic>Ketones</topic><topic>Magnesium</topic><topic>Magnesium Compounds</topic><topic>Magnesium phosphate</topic><topic>Mechanical properties</topic><topic>Mice</topic><topic>Modulus of elasticity</topic><topic>Orthopaedic implants</topic><topic>Orthopedics</topic><topic>Osseointegration</topic><topic>Osteoblasts</topic><topic>Phosphates</topic><topic>Polyether ether ketones</topic><topic>Polyetheretherketone</topic><topic>Polyethylene Glycols</topic><topic>Polymer matrix composites</topic><topic>Polymers</topic><topic>Printing</topic><topic>Printing, Three-Dimensional</topic><topic>Rheological properties</topic><topic>Stability analysis</topic><topic>Submerging</topic><topic>Surgical implants</topic><topic>Thermal stability</topic><topic>Thermogravimetric analysis</topic><topic>Three dimensional composites</topic><topic>Three dimensional printing</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sikder, Prabaha</creatorcontrib><creatorcontrib>Ferreira, Jessica A.</creatorcontrib><creatorcontrib>Fakhrabadi, Ehsan Akbari</creatorcontrib><creatorcontrib>Kantorski, Karla Z.</creatorcontrib><creatorcontrib>Liberatore, Matthew W.</creatorcontrib><creatorcontrib>Bottino, Marco C.</creatorcontrib><creatorcontrib>Bhaduri, Sarit B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Dental materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sikder, Prabaha</au><au>Ferreira, Jessica A.</au><au>Fakhrabadi, Ehsan Akbari</au><au>Kantorski, Karla Z.</au><au>Liberatore, Matthew W.</au><au>Bottino, Marco C.</au><au>Bhaduri, Sarit B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing</atitle><jtitle>Dental materials</jtitle><addtitle>Dent Mater</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>36</volume><issue>7</issue><spage>865</spage><epage>883</epage><pages>865-883</pages><issn>0109-5641</issn><eissn>1879-0097</eissn><abstract>•The composite filaments were successfully developed via melt-blending technique.•AMP-PEEK filaments can serve as feedstock for 3D printing of patient-specific implants.•The bioactivity of the composites significantly increased cell adhesion and proliferation.•AMP-PEEK facilitate in vivo osseointegration and suitable bone regeneration capabilities.
The aim of this study was to develop bioactive and osseointegrable polyetheretherketone (PEEK)-based composite filaments melt-blended with novel amorphous magnesium phosphate (AMP) particles for 3D printing of dental and orthopedic implants.
A series of materials and biological analyses of AMP-PEEK were performed. Thermal stability, thermogravimetric and differential scanning calorimetry curves of as-synthesized AMP were measured. Complex viscosity, elastic modulus and viscous modulus were determined using a rotational rheometer. In vitro bioactivity was analyzed using SBF immersion method. SEM, EDS and XRD were used to study the apatite-forming ability of the AMP-PEEK filaments. Mouse pre-osteoblasts (MC3T3-E1) were cultured and analyzed for cell viability, proliferation and gene expression. For in vivo analyses, bare PEEK was used as the control and 15AMP-PEEK was chosen based on its in vitro cell-related results. After 4 or 12 weeks, animals were euthanized, and the femurs were collected for micro-computed tomography (μ-CT) and histology.
The collected findings confirmed the homogeneous dispersion of AMP particles within the PEEK matrix with no phase degradation. Rheological studies demonstrated that AMP-PEEK composites are good candidates for 3D printing by exhibiting high zero-shear and low infinite-shear viscosities. In vitro results revealed enhanced bioactivity and superior pre-osteoblast cell function in the case of AMP-PEEK composites as compared to bare PEEK. In vivo analyses further corroborated the enhanced osseointegration capacity for AMP-PEEK implants.
Collectively, the present investigation demonstrated that AMP-PEEK composite filaments can serve as feedstock for 3D printing of orthopedic and dental implants due to enhanced bioactivity and osseointegration capacity.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>32451208</pmid><doi>10.1016/j.dental.2020.04.008</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0001-6910-4199</orcidid><orcidid>https://orcid.org/0000-0001-9302-2310</orcidid><orcidid>https://orcid.org/0000-0002-6219-0255</orcidid><orcidid>https://orcid.org/0000-0001-8740-2464</orcidid><orcidid>https://orcid.org/0000-0002-5495-7145</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0109-5641 |
| ispartof | Dental materials, 2020-07, Vol.36 (7), p.865-883 |
| issn | 0109-5641 1879-0097 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7359049 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 3-D printers 3D printing Amorphous magnesium phosphate AMP Animals Apatite Benzophenones Biological activity Biological analysis Biomedical materials Calorimetry Cell viability Computed tomography Dental Implants Dental materials Dental prosthetics Dental restorative materials Differential scanning calorimetry Filaments Gene expression Histology Implants Ketones Magnesium Magnesium Compounds Magnesium phosphate Mechanical properties Mice Modulus of elasticity Orthopaedic implants Orthopedics Osseointegration Osteoblasts Phosphates Polyether ether ketones Polyetheretherketone Polyethylene Glycols Polymer matrix composites Polymers Printing Printing, Three-Dimensional Rheological properties Stability analysis Submerging Surgical implants Thermal stability Thermogravimetric analysis Three dimensional composites Three dimensional printing X-Ray Microtomography |
| title | Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T19%3A24%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bioactive%20amorphous%20magnesium%20phosphate-polyetheretherketone%20composite%20filaments%20for%203D%20printing&rft.jtitle=Dental%20materials&rft.au=Sikder,%20Prabaha&rft.date=2020-07-01&rft.volume=36&rft.issue=7&rft.spage=865&rft.epage=883&rft.pages=865-883&rft.issn=0109-5641&rft.eissn=1879-0097&rft_id=info:doi/10.1016/j.dental.2020.04.008&rft_dat=%3Cproquest_pubme%3E2438721486%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2438721486&rft_id=info:pmid/32451208&rft_els_id=S0109564120301056&rfr_iscdi=true |