Yeast as a promising heterologous host for steroid bioproduction
With the rapid development of synthetic biology and metabolic engineering technologies, yeast has been generally considered as promising hosts for the bioproduction of secondary metabolites. Sterols are essential components of cell membrane, and are the precursors for the biosynthesis of steroid hor...
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| Veröffentlicht in: | Journal of industrial microbiology & biotechnology 2020-10, Vol.47 (9-10), p.829-843 |
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| container_issue | 9-10 |
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| container_title | Journal of industrial microbiology & biotechnology |
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| creator | Xu, Shanhui Li, Yanran |
| description | With the rapid development of synthetic biology and metabolic engineering technologies, yeast has been generally considered as promising hosts for the bioproduction of secondary metabolites. Sterols are essential components of cell membrane, and are the precursors for the biosynthesis of steroid hormones, signaling molecules, and defense molecules in the higher eukaryotes, which are of pharmaceutical and agricultural significance. In this mini-review, we summarize the recent engineering efforts of using yeast to synthesize various steroids, and discuss the structural diversity that the current steroid-producing yeast can achieve, the challenge and the potential of using yeast as the bioproduction platform of various steroids from higher eukaryotes. |
| doi_str_mv | 10.1007/s10295-020-02291-7 |
| format | Article |
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Sterols are essential components of cell membrane, and are the precursors for the biosynthesis of steroid hormones, signaling molecules, and defense molecules in the higher eukaryotes, which are of pharmaceutical and agricultural significance. In this mini-review, we summarize the recent engineering efforts of using yeast to synthesize various steroids, and discuss the structural diversity that the current steroid-producing yeast can achieve, the challenge and the potential of using yeast as the bioproduction platform of various steroids from higher eukaryotes.</description><subject>Agricultural engineering</subject><subject>Biochemistry</subject><subject>Bioinformatics</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Cell membranes</subject><subject>Eukaryotes</subject><subject>Genetic Engineering</subject><subject>Hormones</subject><subject>Inorganic Chemistry</subject><subject>Life Sciences</subject><subject>Metabolic Engineering</subject><subject>Metabolic Engineering and Synthetic Biology - Mini Review</subject><subject>Metabolites</subject><subject>Microbiology</subject><subject>Reviews</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Secondary metabolites</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>Sterols</subject><subject>Sterols - 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| subjects | Agricultural engineering Biochemistry Bioinformatics Biomedical and Life Sciences Biosynthesis Biotechnology Cell membranes Eukaryotes Genetic Engineering Hormones Inorganic Chemistry Life Sciences Metabolic Engineering Metabolic Engineering and Synthetic Biology - Mini Review Metabolites Microbiology Reviews Saccharomyces cerevisiae - metabolism Secondary metabolites Steroid hormones Steroids Sterols Sterols - chemistry Synthetic Biology Yeast Yeasts |
| title | Yeast as a promising heterologous host for steroid bioproduction |
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