Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

ABSTRACT Clinical radiotherapy treats life‐threatening cancers, but the radiation often affects neighboring normal tissues including bone. Acute effects of ionizing radiation include oxidative stress, DNA damage, and cellular apoptosis. We show in this study that a large proportion of bone marrow ce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of bone and mineral research 2020-06, Vol.35 (6), p.1119-1131
Hauptverfasser:	Chandra, Abhishek, Lagnado, Anthony B, Farr, Joshua N, Monroe, David G, Park, Sean, Hachfeld, Christine, Tchkonia, Tamar, Kirkland, James L, Khosla, Sundeep, Passos, João F, Pignolo, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute effects Apoptosis Bone loss Bone marrow DNA damage INK4a protein Ionizing radiation Osteoblasts Osteocytes OSTEOPOROSIS Oxidative stress p16 Protein Phenotypes Quercetin Radiation therapy RADIOTHERAPY SENESCENCE SENOLYTICS TELOMERE DYSFUNCTION Telomeres β-Galactosidase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!