A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe
Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University...
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creator | Borobia, Alberto Carcas, Antonio Arnalich, Francisco Álvarez-Sala, Rodolfo Monserrat-Villatoro, Jaime Quintana, Manuel Figueira, Juan Torres Santos-Olmo, Rosario García-Rodríguez, Julio Martín-Vega, Alberto Buño, Antonio Ramírez, Elena Martínez-Alés, Gonzalo García-Arenzana, Nicolás Núñez, M. Martí-de-Gracia, Milagros Moreno Ramos, Francisco Reinoso-Barbero, Francisco Martin-Quiros, Alejandro Rivera Núñez, Angélica Mingorance, Jesús Carpio Segura, Carlos Prieto Arribas, Daniel Rey Cuevas, Esther Prados Sánchez, Concepción Rios, Juan Hernán, Miguel Frías, Jesús Arribas, José |
description | Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes. |
doi_str_mv | 10.3390/jcm9061733 |
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This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9061733</identifier><identifier>PMID: 32512688</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age groups ; Clinical medicine ; Coronaviruses ; COVID-19 ; Data collection ; Demographics ; Diabetes ; Disease transmission ; Dyspnea ; Hospitalization ; Hypertension ; Infections ; Laboratories ; Mortality ; Oxygen saturation ; Pandemics ; Proteins ; Severe acute respiratory syndrome coronavirus 2 ; Teaching hospitals</subject><ispartof>Journal of clinical medicine, 2020-06, Vol.9 (6), p.1733</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.</description><subject>Age groups</subject><subject>Clinical medicine</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Data collection</subject><subject>Demographics</subject><subject>Diabetes</subject><subject>Disease transmission</subject><subject>Dyspnea</subject><subject>Hospitalization</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Mortality</subject><subject>Oxygen saturation</subject><subject>Pandemics</subject><subject>Proteins</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Teaching 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Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe</title><author>Borobia, Alberto ; Carcas, Antonio ; Arnalich, Francisco ; Álvarez-Sala, Rodolfo ; Monserrat-Villatoro, Jaime ; Quintana, Manuel ; Figueira, Juan ; Torres Santos-Olmo, Rosario ; García-Rodríguez, Julio ; Martín-Vega, Alberto ; Buño, Antonio ; Ramírez, Elena ; Martínez-Alés, Gonzalo ; García-Arenzana, Nicolás ; Núñez, M. ; Martí-de-Gracia, Milagros ; Moreno Ramos, Francisco ; Reinoso-Barbero, Francisco ; Martin-Quiros, Alejandro ; Rivera Núñez, Angélica ; Mingorance, Jesús ; Carpio Segura, Carlos ; Prieto Arribas, Daniel ; Rey Cuevas, Esther ; Prados Sánchez, Concepción ; Rios, Juan ; Hernán, Miguel ; Frías, Jesús ; Arribas, 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Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe</atitle><jtitle>Journal of clinical medicine</jtitle><date>2020-06-04</date><risdate>2020</risdate><volume>9</volume><issue>6</issue><spage>1733</spage><pages>1733-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. 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source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Age groups Clinical medicine Coronaviruses COVID-19 Data collection Demographics Diabetes Disease transmission Dyspnea Hospitalization Hypertension Infections Laboratories Mortality Oxygen saturation Pandemics Proteins Severe acute respiratory syndrome coronavirus 2 Teaching hospitals |
title | A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe |
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