MK801-induced locomotor activity in preweanling and adolescent male and female rats: role of the dopamine and serotonin systems

Rationale MK801, like other NMDA receptor open-channel blockers (e.g., ketamine and phencyclidine), increases the locomotor activity of rats and mice. Whether this behavioral effect ultimately relies on monoamine neurotransmission is of dispute. Objective The purpose of this study was to determine w...

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Veröffentlicht in:	Psychopharmacology 2020-08, Vol.237 (8), p.2469-2483
Hauptverfasser:	McDougall, Sanders A., Apodaca, Matthew G., Park, Ginny I., Teran, Angie, Baum, Timothy J., Montejano, Nazaret R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age differences Animal behavior Animal experimentation Biomedical and Life Sciences Biomedicine Corticosteroids Dopamine Glutamic acid receptors (ionotropic) Ketamine Locomotor activity N-Methyl-D-aspartic acid receptors Neurosciences Neurotransmission Original Investigation Pharmacology/Toxicology Phencyclidine Phenols Phenylalanine Psychiatry Reserpine Rodents Serotonin Sex Sexes Teenage girls Teenagers Tyrosine
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