Host Immune Response and Novel Diagnostic Approach to NTM Infections
The incidence and prevalence of non-tuberculous mycobacteria (NTM) infections are steadily increasing worldwide, partially due to the increased incidence of immunocompromised conditions, such as the post-transplantation state. The importance of proper diagnosis and management of NTM infection has be...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2020-06, Vol.21 (12), p.4351 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 12 |
| container_start_page | 4351 |
| container_title | International journal of molecular sciences |
| container_volume | 21 |
| creator | Abe, Yuko Fukushima, Kiyoharu Hosono, Yuki Matsumoto, Yuki Motooka, Daisuke Ose, Naoko Nakamura, Shota Kitada, Seigo Kida, Hiroshi Kumanogoh, Atsushi |
| description | The incidence and prevalence of non-tuberculous mycobacteria (NTM) infections are steadily increasing worldwide, partially due to the increased incidence of immunocompromised conditions, such as the post-transplantation state. The importance of proper diagnosis and management of NTM infection has been recently recognized. Host immunological responses play integral roles in vulnerability to NTM infections, and may contribute to the onset of specific types of NTM infection. Furthermore, distinct NTM species are known to affect and attenuate these host immune responses in unique manners. Therefore, host immune responses must be understood with respect to each causative NTM species. Here, we review innate, cellular-mediated, and humoral immunity to NTM and provide perspectives on novel diagnostic approaches regarding each NTM species. |
| doi_str_mv | 10.3390/ijms21124351 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7352966</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2416265227</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-4021047e99ae08d2d89ef416a0c5716f7722a75da060fa0c549af028dead87393</originalsourceid><addsrcrecordid>eNpdkcFLwzAUxoMobk5vniXgxYPT5DVtmoswNnWDOUHmOcQ23TrapDbtwP_ezM0xPb3He7_38T0-hC4puQsCQe7zVemAUmBBSI9QlzKAPiERPz7oO-jMuRUhEEAoTlHHF04Ej7toNLauwZOybI3Gb9pV1jiNlUnxzK51gUe5WhiP5AkeVFVtVbLEjcWz-QuemEwnTe4PztFJpgqnL3a1h96fHufDcX_6-jwZDqb9hPG46TMClDCuhVCaxCmksdAZo5EiSchplHEOoHiYKhKRbDNkQmUE4lSrNOaBCHroYatbtR-lThNtmloVsqrzUtVf0qpc_t2YfCkXdi15EIKIIi9wsxOo7WerXSPL3CW6KJTRtnUSvBuIQgDu0et_6Mq2tfHv_VAEBDDw1O2WSmrrXK2zvRlK5CYeeRiPx68OH9jDv3kE3zcPil0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2416029242</pqid></control><display><type>article</type><title>Host Immune Response and Novel Diagnostic Approach to NTM Infections</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Abe, Yuko ; Fukushima, Kiyoharu ; Hosono, Yuki ; Matsumoto, Yuki ; Motooka, Daisuke ; Ose, Naoko ; Nakamura, Shota ; Kitada, Seigo ; Kida, Hiroshi ; Kumanogoh, Atsushi</creator><creatorcontrib>Abe, Yuko ; Fukushima, Kiyoharu ; Hosono, Yuki ; Matsumoto, Yuki ; Motooka, Daisuke ; Ose, Naoko ; Nakamura, Shota ; Kitada, Seigo ; Kida, Hiroshi ; Kumanogoh, Atsushi</creatorcontrib><description>The incidence and prevalence of non-tuberculous mycobacteria (NTM) infections are steadily increasing worldwide, partially due to the increased incidence of immunocompromised conditions, such as the post-transplantation state. The importance of proper diagnosis and management of NTM infection has been recently recognized. Host immunological responses play integral roles in vulnerability to NTM infections, and may contribute to the onset of specific types of NTM infection. Furthermore, distinct NTM species are known to affect and attenuate these host immune responses in unique manners. Therefore, host immune responses must be understood with respect to each causative NTM species. Here, we review innate, cellular-mediated, and humoral immunity to NTM and provide perspectives on novel diagnostic approaches regarding each NTM species.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21124351</identifier><identifier>PMID: 32570978</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adaptive immunity ; Cytokines ; Dendritic cells ; Humans ; Humoral immunity ; Immune response ; Immune system ; Immunity ; Immunology ; Incidence ; Infections ; Lectins ; Ligands ; Lipids ; Lymphocytes ; Mutation ; Mycobacterium Infections, Nontuberculous - diagnosis ; Mycobacterium Infections, Nontuberculous - epidemiology ; Mycobacterium Infections, Nontuberculous - immunology ; Nontuberculous Mycobacteria - immunology ; Pathogens ; Prevalence ; Review ; Roles ; Transplantation ; Tuberculosis ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2020-06, Vol.21 (12), p.4351</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-4021047e99ae08d2d89ef416a0c5716f7722a75da060fa0c549af028dead87393</citedby><cites>FETCH-LOGICAL-c478t-4021047e99ae08d2d89ef416a0c5716f7722a75da060fa0c549af028dead87393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352966/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352966/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32570978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abe, Yuko</creatorcontrib><creatorcontrib>Fukushima, Kiyoharu</creatorcontrib><creatorcontrib>Hosono, Yuki</creatorcontrib><creatorcontrib>Matsumoto, Yuki</creatorcontrib><creatorcontrib>Motooka, Daisuke</creatorcontrib><creatorcontrib>Ose, Naoko</creatorcontrib><creatorcontrib>Nakamura, Shota</creatorcontrib><creatorcontrib>Kitada, Seigo</creatorcontrib><creatorcontrib>Kida, Hiroshi</creatorcontrib><creatorcontrib>Kumanogoh, Atsushi</creatorcontrib><title>Host Immune Response and Novel Diagnostic Approach to NTM Infections</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The incidence and prevalence of non-tuberculous mycobacteria (NTM) infections are steadily increasing worldwide, partially due to the increased incidence of immunocompromised conditions, such as the post-transplantation state. The importance of proper diagnosis and management of NTM infection has been recently recognized. Host immunological responses play integral roles in vulnerability to NTM infections, and may contribute to the onset of specific types of NTM infection. Furthermore, distinct NTM species are known to affect and attenuate these host immune responses in unique manners. Therefore, host immune responses must be understood with respect to each causative NTM species. Here, we review innate, cellular-mediated, and humoral immunity to NTM and provide perspectives on novel diagnostic approaches regarding each NTM species.</description><subject>Adaptive immunity</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Humans</subject><subject>Humoral immunity</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunology</subject><subject>Incidence</subject><subject>Infections</subject><subject>Lectins</subject><subject>Ligands</subject><subject>Lipids</subject><subject>Lymphocytes</subject><subject>Mutation</subject><subject>Mycobacterium Infections, Nontuberculous - diagnosis</subject><subject>Mycobacterium Infections, Nontuberculous - epidemiology</subject><subject>Mycobacterium Infections, Nontuberculous - immunology</subject><subject>Nontuberculous Mycobacteria - immunology</subject><subject>Pathogens</subject><subject>Prevalence</subject><subject>Review</subject><subject>Roles</subject><subject>Transplantation</subject><subject>Tuberculosis</subject><subject>Tumor necrosis factor-TNF</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkcFLwzAUxoMobk5vniXgxYPT5DVtmoswNnWDOUHmOcQ23TrapDbtwP_ezM0xPb3He7_38T0-hC4puQsCQe7zVemAUmBBSI9QlzKAPiERPz7oO-jMuRUhEEAoTlHHF04Ej7toNLauwZOybI3Gb9pV1jiNlUnxzK51gUe5WhiP5AkeVFVtVbLEjcWz-QuemEwnTe4PztFJpgqnL3a1h96fHufDcX_6-jwZDqb9hPG46TMClDCuhVCaxCmksdAZo5EiSchplHEOoHiYKhKRbDNkQmUE4lSrNOaBCHroYatbtR-lThNtmloVsqrzUtVf0qpc_t2YfCkXdi15EIKIIi9wsxOo7WerXSPL3CW6KJTRtnUSvBuIQgDu0et_6Mq2tfHv_VAEBDDw1O2WSmrrXK2zvRlK5CYeeRiPx68OH9jDv3kE3zcPil0</recordid><startdate>20200618</startdate><enddate>20200618</enddate><creator>Abe, Yuko</creator><creator>Fukushima, Kiyoharu</creator><creator>Hosono, Yuki</creator><creator>Matsumoto, Yuki</creator><creator>Motooka, Daisuke</creator><creator>Ose, Naoko</creator><creator>Nakamura, Shota</creator><creator>Kitada, Seigo</creator><creator>Kida, Hiroshi</creator><creator>Kumanogoh, Atsushi</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200618</creationdate><title>Host Immune Response and Novel Diagnostic Approach to NTM Infections</title><author>Abe, Yuko ; Fukushima, Kiyoharu ; Hosono, Yuki ; Matsumoto, Yuki ; Motooka, Daisuke ; Ose, Naoko ; Nakamura, Shota ; Kitada, Seigo ; Kida, Hiroshi ; Kumanogoh, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-4021047e99ae08d2d89ef416a0c5716f7722a75da060fa0c549af028dead87393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adaptive immunity</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>Humans</topic><topic>Humoral immunity</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunology</topic><topic>Incidence</topic><topic>Infections</topic><topic>Lectins</topic><topic>Ligands</topic><topic>Lipids</topic><topic>Lymphocytes</topic><topic>Mutation</topic><topic>Mycobacterium Infections, Nontuberculous - diagnosis</topic><topic>Mycobacterium Infections, Nontuberculous - epidemiology</topic><topic>Mycobacterium Infections, Nontuberculous - immunology</topic><topic>Nontuberculous Mycobacteria - immunology</topic><topic>Pathogens</topic><topic>Prevalence</topic><topic>Review</topic><topic>Roles</topic><topic>Transplantation</topic><topic>Tuberculosis</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abe, Yuko</creatorcontrib><creatorcontrib>Fukushima, Kiyoharu</creatorcontrib><creatorcontrib>Hosono, Yuki</creatorcontrib><creatorcontrib>Matsumoto, Yuki</creatorcontrib><creatorcontrib>Motooka, Daisuke</creatorcontrib><creatorcontrib>Ose, Naoko</creatorcontrib><creatorcontrib>Nakamura, Shota</creatorcontrib><creatorcontrib>Kitada, Seigo</creatorcontrib><creatorcontrib>Kida, Hiroshi</creatorcontrib><creatorcontrib>Kumanogoh, Atsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abe, Yuko</au><au>Fukushima, Kiyoharu</au><au>Hosono, Yuki</au><au>Matsumoto, Yuki</au><au>Motooka, Daisuke</au><au>Ose, Naoko</au><au>Nakamura, Shota</au><au>Kitada, Seigo</au><au>Kida, Hiroshi</au><au>Kumanogoh, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Host Immune Response and Novel Diagnostic Approach to NTM Infections</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-06-18</date><risdate>2020</risdate><volume>21</volume><issue>12</issue><spage>4351</spage><pages>4351-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The incidence and prevalence of non-tuberculous mycobacteria (NTM) infections are steadily increasing worldwide, partially due to the increased incidence of immunocompromised conditions, such as the post-transplantation state. The importance of proper diagnosis and management of NTM infection has been recently recognized. Host immunological responses play integral roles in vulnerability to NTM infections, and may contribute to the onset of specific types of NTM infection. Furthermore, distinct NTM species are known to affect and attenuate these host immune responses in unique manners. Therefore, host immune responses must be understood with respect to each causative NTM species. Here, we review innate, cellular-mediated, and humoral immunity to NTM and provide perspectives on novel diagnostic approaches regarding each NTM species.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32570978</pmid><doi>10.3390/ijms21124351</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2020-06, Vol.21 (12), p.4351 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7352966 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adaptive immunity Cytokines Dendritic cells Humans Humoral immunity Immune response Immune system Immunity Immunology Incidence Infections Lectins Ligands Lipids Lymphocytes Mutation Mycobacterium Infections, Nontuberculous - diagnosis Mycobacterium Infections, Nontuberculous - epidemiology Mycobacterium Infections, Nontuberculous - immunology Nontuberculous Mycobacteria - immunology Pathogens Prevalence Review Roles Transplantation Tuberculosis Tumor necrosis factor-TNF |
| title | Host Immune Response and Novel Diagnostic Approach to NTM Infections |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T20%3A36%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Host%20Immune%20Response%20and%20Novel%20Diagnostic%20Approach%20to%20NTM%20Infections&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Abe,%20Yuko&rft.date=2020-06-18&rft.volume=21&rft.issue=12&rft.spage=4351&rft.pages=4351-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms21124351&rft_dat=%3Cproquest_pubme%3E2416265227%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2416029242&rft_id=info:pmid/32570978&rfr_iscdi=true |