The Metabolism of Epoxyeicosatrienoic Acids by Soluble Epoxide Hydrolase Is Protective against the Development of Vascular Calcification

This study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes endothelium-derived epoxyeicosatrienoic acids, plays a role in vascular calcification. The sEH inhibitor -4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid ( -AUCB) potentiated the increase in calciu...

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Veröffentlicht in:	International journal of molecular sciences 2020-06, Vol.21 (12), p.4313
Hauptverfasser:	Varennes, Olivier, Mentaverri, Romuald, Duflot, Thomas, Kauffenstein, Gilles, Objois, Thibaut, Lenglet, Gaëlle, Avondo, Carine, Morisseau, Christophe, Brazier, Michel, Kamel, Saïd, Six, Isabelle, Bellien, Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Animals Aorta Benzoic acid Bioavailability Biomedical materials Calcification Calcification (ectopic) Calcium Carotid Arteries - metabolism Carotid Arteries - pathology Cbfa-1 protein Cell Differentiation Cytochrome Cytochrome P450 Cytochromes P450 Disease Susceptibility Endothelium Endothelium - metabolism Epoxide hydrolase Epoxide Hydrolases - metabolism Experiments Fatty Acids, Monounsaturated - metabolism Fluconazole Gene expression Humans Kinases Life Sciences Lipid Metabolism Metabolism Metabolites Mineralization Muscles Phosphatase Phosphoric Monoester Hydrolases - metabolism Plaques Protein kinase A Rats RNA, Messenger - genetics Smooth muscle Staphylococcal enterotoxin H Vascular Calcification - etiology Vascular Calcification - metabolism
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