Vitamin C in Home Parenteral Nutrition: A Need for Monitoring
To date, there are no recommendations about screening plasma vitamin C concentration and adjust its supplementation in patients on long-term home parenteral nutrition (HPN). The aim of this study was to evaluate vitamin C status and determine if a commercial multivitamin preparation (CMVP) containin...
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| Veröffentlicht in: | Nutrients 2020-06, Vol.12 (6), p.1667 |
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| creator | Grillot, Julienne Ait, Sabrina Bergoin, Charlotte Couronne, Thomas Blond, Emilie Peraldi, Catherine Barnoud, Didier Chambrier, Cécile Lauverjat, Madeleine |
| description | To date, there are no recommendations about screening plasma vitamin C concentration and adjust its supplementation in patients on long-term home parenteral nutrition (HPN). The aim of this study was to evaluate vitamin C status and determine if a commercial multivitamin preparation (CMVP) containing 125 mg of vitamin C is sufficient in stable patients on HPN. All clinically stable patients receiving HPN or an intravenous fluid infusion at least two times per week for at least 6 months, hospitalized for nutritional assessment, were retrospectively included, for a total of 186 patients. We found that 29% of the patients had vitamin C insufficiency (i.e., |
| doi_str_mv | 10.3390/nu12061667 |
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= 0.002) and intake of only 125 mg of vitamin C (
= 0.001) were negatively associated with vitamin C levels, and duration of follow-up in our referral center (
= 0.009) was positively associated with vitamin C levels. In multivariate analysis, only CRP (
= 0.001) and intake of 125 mg of vitamin C (
< 0.0001) were independently associated with low plasma vitamin C concentration. Patients receiving only CMVP with a low plasma vitamin C level significantly received personal compounded HPN (
= 0.008) and presented an inflammatory syndrome (
= 0.002). Vitamin C insufficiency is frequent in individuals undergoing home parenteral nutrition; therefore, there is a need to monitor plasma vitamin C levels, especially in patients on HPN with an inflammatory syndrome and only on CMVP.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12061667</identifier><identifier>PMID: 32503297</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acids ; Adult ; Aged ; Ascorbic acid ; Ascorbic Acid - administration & dosage ; Ascorbic Acid - analysis ; Ascorbic Acid - blood ; Ascorbic Acid Deficiency - blood ; Ascorbic Acid Deficiency - diagnosis ; Ascorbic Acid Deficiency - etiology ; Ascorbic Acid Deficiency - prevention & control ; Biomarkers - blood ; C-reactive protein ; Eating - physiology ; Enteral nutrition ; Female ; Humans ; Inflammation ; Inflammation - etiology ; Intravenous administration ; Kidney diseases ; Life Sciences ; Male ; Metabolism ; Middle Aged ; Monitoring, Physiologic ; Multivariate analysis ; Nutrition ; Nutrition Assessment ; Nutritional Physiological Phenomena - physiology ; Nutritional Status ; Parenteral nutrition ; Parenteral Nutrition, Home Total - adverse effects ; Patients ; Plasma ; Retrospective Studies ; Trace elements ; Vitamin C</subject><ispartof>Nutrients, 2020-06, Vol.12 (6), p.1667</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-fef4def67f36c78dc3196da7bad67d45ed37a07aafd2acc381dc53c2ce1be28f3</citedby><cites>FETCH-LOGICAL-c440t-fef4def67f36c78dc3196da7bad67d45ed37a07aafd2acc381dc53c2ce1be28f3</cites><orcidid>0000-0002-3929-5382 ; 0000-0002-4606-8356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352530/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352530/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32503297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02902508$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Grillot, Julienne</creatorcontrib><creatorcontrib>Ait, Sabrina</creatorcontrib><creatorcontrib>Bergoin, Charlotte</creatorcontrib><creatorcontrib>Couronne, Thomas</creatorcontrib><creatorcontrib>Blond, Emilie</creatorcontrib><creatorcontrib>Peraldi, Catherine</creatorcontrib><creatorcontrib>Barnoud, Didier</creatorcontrib><creatorcontrib>Chambrier, Cécile</creatorcontrib><creatorcontrib>Lauverjat, Madeleine</creatorcontrib><title>Vitamin C in Home Parenteral Nutrition: A Need for Monitoring</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>To date, there are no recommendations about screening plasma vitamin C concentration and adjust its supplementation in patients on long-term home parenteral nutrition (HPN). The aim of this study was to evaluate vitamin C status and determine if a commercial multivitamin preparation (CMVP) containing 125 mg of vitamin C is sufficient in stable patients on HPN. All clinically stable patients receiving HPN or an intravenous fluid infusion at least two times per week for at least 6 months, hospitalized for nutritional assessment, were retrospectively included, for a total of 186 patients. We found that 29% of the patients had vitamin C insufficiency (i.e., <25 µmol/L). In univariate analysis, C-reactive protein (CRP) (
= 0.002) and intake of only 125 mg of vitamin C (
= 0.001) were negatively associated with vitamin C levels, and duration of follow-up in our referral center (
= 0.009) was positively associated with vitamin C levels. In multivariate analysis, only CRP (
= 0.001) and intake of 125 mg of vitamin C (
< 0.0001) were independently associated with low plasma vitamin C concentration. Patients receiving only CMVP with a low plasma vitamin C level significantly received personal compounded HPN (
= 0.008) and presented an inflammatory syndrome (
= 0.002). Vitamin C insufficiency is frequent in individuals undergoing home parenteral nutrition; therefore, there is a need to monitor plasma vitamin C levels, especially in patients on HPN with an inflammatory syndrome and only on CMVP.</description><subject>Acids</subject><subject>Adult</subject><subject>Aged</subject><subject>Ascorbic acid</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Ascorbic Acid - analysis</subject><subject>Ascorbic Acid - blood</subject><subject>Ascorbic Acid Deficiency - blood</subject><subject>Ascorbic Acid Deficiency - diagnosis</subject><subject>Ascorbic Acid Deficiency - etiology</subject><subject>Ascorbic Acid Deficiency - prevention & control</subject><subject>Biomarkers - blood</subject><subject>C-reactive protein</subject><subject>Eating - physiology</subject><subject>Enteral nutrition</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Intravenous administration</subject><subject>Kidney diseases</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic</subject><subject>Multivariate analysis</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Nutritional Physiological Phenomena - physiology</subject><subject>Nutritional Status</subject><subject>Parenteral nutrition</subject><subject>Parenteral Nutrition, Home Total - adverse effects</subject><subject>Patients</subject><subject>Plasma</subject><subject>Retrospective Studies</subject><subject>Trace elements</subject><subject>Vitamin C</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkUtLAzEUhYMoVrQbf4AMuFGhmuTOJFNBoRS1Qn0s1G1I89BIJ9HMjOC_N0O1VrNIQvLdk5N7ENol-BhgiE98SyhmhDG-hrYo5nTAWA7rK_se6tf1K-4Gx5zBJuoBLTDQId9CZ0-ukZXz2ThL0yRUJruX0fjGRDnPbtsmusYFf5qNsltjdGZDzG6Cd02Izj_voA0r57Xpf6_b6PHy4mE8GUzvrq7Ho-lA5TluBtbYXBvLuAWmeKkVkCHTks-kZlznhdHAJeZSWk2lUlASrQpQVBkyM7S0sI3OF7pv7awyWiV_yZ54i66S8VME6cTfG-9exHP4EBwKWgBOAocLgZd_ZZPRVHRnmA5xakr5QRJ78P1YDO-tqRtRuVqZ-Vx6E9pa0JxgYCUpO3T_H_oa2uhTKxLFGE6pQEcdLSgVQ11HY5cOCBZdiOI3xATvrX51if5EBl_pwpYy</recordid><startdate>20200603</startdate><enddate>20200603</enddate><creator>Grillot, Julienne</creator><creator>Ait, Sabrina</creator><creator>Bergoin, Charlotte</creator><creator>Couronne, Thomas</creator><creator>Blond, Emilie</creator><creator>Peraldi, Catherine</creator><creator>Barnoud, Didier</creator><creator>Chambrier, Cécile</creator><creator>Lauverjat, Madeleine</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3929-5382</orcidid><orcidid>https://orcid.org/0000-0002-4606-8356</orcidid></search><sort><creationdate>20200603</creationdate><title>Vitamin C in Home Parenteral Nutrition: A Need for Monitoring</title><author>Grillot, Julienne ; 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The aim of this study was to evaluate vitamin C status and determine if a commercial multivitamin preparation (CMVP) containing 125 mg of vitamin C is sufficient in stable patients on HPN. All clinically stable patients receiving HPN or an intravenous fluid infusion at least two times per week for at least 6 months, hospitalized for nutritional assessment, were retrospectively included, for a total of 186 patients. We found that 29% of the patients had vitamin C insufficiency (i.e., <25 µmol/L). In univariate analysis, C-reactive protein (CRP) (
= 0.002) and intake of only 125 mg of vitamin C (
= 0.001) were negatively associated with vitamin C levels, and duration of follow-up in our referral center (
= 0.009) was positively associated with vitamin C levels. In multivariate analysis, only CRP (
= 0.001) and intake of 125 mg of vitamin C (
< 0.0001) were independently associated with low plasma vitamin C concentration. Patients receiving only CMVP with a low plasma vitamin C level significantly received personal compounded HPN (
= 0.008) and presented an inflammatory syndrome (
= 0.002). Vitamin C insufficiency is frequent in individuals undergoing home parenteral nutrition; therefore, there is a need to monitor plasma vitamin C levels, especially in patients on HPN with an inflammatory syndrome and only on CMVP.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32503297</pmid><doi>10.3390/nu12061667</doi><orcidid>https://orcid.org/0000-0002-3929-5382</orcidid><orcidid>https://orcid.org/0000-0002-4606-8356</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2020-06, Vol.12 (6), p.1667 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Acids Adult Aged Ascorbic acid Ascorbic Acid - administration & dosage Ascorbic Acid - analysis Ascorbic Acid - blood Ascorbic Acid Deficiency - blood Ascorbic Acid Deficiency - diagnosis Ascorbic Acid Deficiency - etiology Ascorbic Acid Deficiency - prevention & control Biomarkers - blood C-reactive protein Eating - physiology Enteral nutrition Female Humans Inflammation Inflammation - etiology Intravenous administration Kidney diseases Life Sciences Male Metabolism Middle Aged Monitoring, Physiologic Multivariate analysis Nutrition Nutrition Assessment Nutritional Physiological Phenomena - physiology Nutritional Status Parenteral nutrition Parenteral Nutrition, Home Total - adverse effects Patients Plasma Retrospective Studies Trace elements Vitamin C |
| title | Vitamin C in Home Parenteral Nutrition: A Need for Monitoring |
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