Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy
Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients. Benefits include not...
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| Veröffentlicht in: | Nutrients 2020-06, Vol.12 (6), p.1675 |
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| description | Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients. Benefits include not only better nutrition, but also decreased mucosal damage (mucositis, stomatitis, pharyngitis, esophagitis, and enteritis). Glutamine supplementation in a high protein diet (10 grams/day) + disaccharides, such as sucrose and/or trehalose, is a combination that increases glutamine uptake by mucosal cells. This increased topical effect can reduce painful mucosal symptoms and ulceration associated with chemotherapy and radiation in the head and neck region, esophagus, stomach and small intestine. Topical and oral glutamine seem to be the preferred routes for this amino acid to promote mucosal healing during and after cancer treatment. |
| doi_str_mv | 10.3390/nu12061675 |
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Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients. Benefits include not only better nutrition, but also decreased mucosal damage (mucositis, stomatitis, pharyngitis, esophagitis, and enteritis). Glutamine supplementation in a high protein diet (10 grams/day) + disaccharides, such as sucrose and/or trehalose, is a combination that increases glutamine uptake by mucosal cells. This increased topical effect can reduce painful mucosal symptoms and ulceration associated with chemotherapy and radiation in the head and neck region, esophagus, stomach and small intestine. Topical and oral glutamine seem to be the preferred routes for this amino acid to promote mucosal healing during and after cancer treatment.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12061675</identifier><identifier>PMID: 32512833</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject><![CDATA[Amino acids ; Antineoplastic Agents - adverse effects ; Cancer ; Cancer therapies ; Chemotherapy ; Cytokines ; Diet, High-Protein ; Dietary Proteins - administration & dosage ; Dietary Sucrose - administration & dosage ; Dietary Supplements ; Disaccharides ; Enteral nutrition ; Enteritis ; Esophagitis ; Esophagus ; Ewings sarcoma ; Glutamine ; Glutamine - administration & dosage ; Glutamine - metabolism ; Glutamine - pharmacology ; Healing ; High protein diet ; Humans ; Infections ; Inflammation ; Intestine ; Lymphocytes ; Malnutrition ; Malnutrition - etiology ; Medical prognosis ; Metabolism ; Mucosa ; Mucositis ; Mucositis - etiology ; Mucositis - physiopathology ; Mucositis - prevention & control ; Mucositis - therapy ; Mucous Membrane - metabolism ; Neoplasms - drug therapy ; Neoplasms - radiotherapy ; Nutrition ; Ostomy ; Pain management ; Parenteral nutrition ; Pharyngitis ; Quality of life ; Radiation ; Radiation damage ; Radiation therapy ; Radiotherapy - adverse effects ; Review ; Sarcopenia ; Small intestine ; Stomatitis ; Sucrose ; Sugar ; Transplants & implants ; Trehalose ; Trehalose - administration & dosage ; Tumors ; Wound Healing - drug effects]]></subject><ispartof>Nutrients, 2020-06, Vol.12 (6), p.1675</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-4dfca6742569fb23ae02a187b9f2c5867e262758331666f78662d76ea85bc24d3</citedby><cites>FETCH-LOGICAL-c472t-4dfca6742569fb23ae02a187b9f2c5867e262758331666f78662d76ea85bc24d3</cites><orcidid>0000-0002-0011-0969</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352314/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352314/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32512833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Peter M</creatorcontrib><creatorcontrib>Lalla, Rajesh V</creatorcontrib><title>Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients. Benefits include not only better nutrition, but also decreased mucosal damage (mucositis, stomatitis, pharyngitis, esophagitis, and enteritis). Glutamine supplementation in a high protein diet (10 grams/day) + disaccharides, such as sucrose and/or trehalose, is a combination that increases glutamine uptake by mucosal cells. This increased topical effect can reduce painful mucosal symptoms and ulceration associated with chemotherapy and radiation in the head and neck region, esophagus, stomach and small intestine. Topical and oral glutamine seem to be the preferred routes for this amino acid to promote mucosal healing during and after cancer treatment.</description><subject>Amino acids</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Cytokines</subject><subject>Diet, High-Protein</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Dietary Sucrose - administration & dosage</subject><subject>Dietary Supplements</subject><subject>Disaccharides</subject><subject>Enteral nutrition</subject><subject>Enteritis</subject><subject>Esophagitis</subject><subject>Esophagus</subject><subject>Ewings sarcoma</subject><subject>Glutamine</subject><subject>Glutamine - administration & dosage</subject><subject>Glutamine - metabolism</subject><subject>Glutamine - pharmacology</subject><subject>Healing</subject><subject>High protein diet</subject><subject>Humans</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Intestine</subject><subject>Lymphocytes</subject><subject>Malnutrition</subject><subject>Malnutrition - etiology</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Mucosa</subject><subject>Mucositis</subject><subject>Mucositis - etiology</subject><subject>Mucositis - physiopathology</subject><subject>Mucositis - prevention & control</subject><subject>Mucositis - therapy</subject><subject>Mucous Membrane - metabolism</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - radiotherapy</subject><subject>Nutrition</subject><subject>Ostomy</subject><subject>Pain management</subject><subject>Parenteral nutrition</subject><subject>Pharyngitis</subject><subject>Quality of life</subject><subject>Radiation</subject><subject>Radiation damage</subject><subject>Radiation therapy</subject><subject>Radiotherapy - adverse effects</subject><subject>Review</subject><subject>Sarcopenia</subject><subject>Small intestine</subject><subject>Stomatitis</subject><subject>Sucrose</subject><subject>Sugar</subject><subject>Transplants & implants</subject><subject>Trehalose</subject><subject>Trehalose - administration & dosage</subject><subject>Tumors</subject><subject>Wound Healing - drug effects</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpVkV9LwzAUxYMobsy9-AEk4JtQzZ8maV-EUXQKE0Hmc8jSdMtok5m0wr69HZtz3pd7L_fHuQcOANcY3VOaowfXYYI45oKdgSFBgiScp_T8ZB6AcYxrtCuBBKeXYEAJwySjdAj0tO5a1VhnYOUDnDSmtj6o1noHfQU_VGn3i3IlLFam8e3KBLXZwkmMXvdHU8K3TvtoWxth2QXrlrBQTpsA53v0ClxUqo5mfOgj8Pn8NC9ektn79LWYzBKdCtImaVlpxUVKGM-rBaHKIKJwJhZ5RTTLuDCEE8F625hzXomMc1IKblTGFpqkJR2Bx73upls0ptTGtUHVchNso8JWemXl_4uzK7n031JQRihOe4Hbg0DwX52JrVz7LrjesyQpRixlOM976m5P6eBjDKY6fsBI7jKRf5n08M2ppyP6mwD9Achlh9Y</recordid><startdate>20200604</startdate><enddate>20200604</enddate><creator>Anderson, Peter M</creator><creator>Lalla, Rajesh V</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0011-0969</orcidid></search><sort><creationdate>20200604</creationdate><title>Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy</title><author>Anderson, Peter M ; Lalla, Rajesh V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-4dfca6742569fb23ae02a187b9f2c5867e262758331666f78662d76ea85bc24d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acids</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Cytokines</topic><topic>Diet, High-Protein</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Dietary Sucrose - administration & dosage</topic><topic>Dietary Supplements</topic><topic>Disaccharides</topic><topic>Enteral nutrition</topic><topic>Enteritis</topic><topic>Esophagitis</topic><topic>Esophagus</topic><topic>Ewings sarcoma</topic><topic>Glutamine</topic><topic>Glutamine - administration & dosage</topic><topic>Glutamine - metabolism</topic><topic>Glutamine - pharmacology</topic><topic>Healing</topic><topic>High protein diet</topic><topic>Humans</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Intestine</topic><topic>Lymphocytes</topic><topic>Malnutrition</topic><topic>Malnutrition - etiology</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Mucosa</topic><topic>Mucositis</topic><topic>Mucositis - etiology</topic><topic>Mucositis - physiopathology</topic><topic>Mucositis - prevention & control</topic><topic>Mucositis - therapy</topic><topic>Mucous Membrane - metabolism</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - radiotherapy</topic><topic>Nutrition</topic><topic>Ostomy</topic><topic>Pain management</topic><topic>Parenteral nutrition</topic><topic>Pharyngitis</topic><topic>Quality of life</topic><topic>Radiation</topic><topic>Radiation damage</topic><topic>Radiation therapy</topic><topic>Radiotherapy - adverse effects</topic><topic>Review</topic><topic>Sarcopenia</topic><topic>Small intestine</topic><topic>Stomatitis</topic><topic>Sucrose</topic><topic>Sugar</topic><topic>Transplants & implants</topic><topic>Trehalose</topic><topic>Trehalose - administration & dosage</topic><topic>Tumors</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Peter M</creatorcontrib><creatorcontrib>Lalla, Rajesh V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Peter M</au><au>Lalla, Rajesh V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2020-06-04</date><risdate>2020</risdate><volume>12</volume><issue>6</issue><spage>1675</spage><pages>1675-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients. Benefits include not only better nutrition, but also decreased mucosal damage (mucositis, stomatitis, pharyngitis, esophagitis, and enteritis). Glutamine supplementation in a high protein diet (10 grams/day) + disaccharides, such as sucrose and/or trehalose, is a combination that increases glutamine uptake by mucosal cells. This increased topical effect can reduce painful mucosal symptoms and ulceration associated with chemotherapy and radiation in the head and neck region, esophagus, stomach and small intestine. Topical and oral glutamine seem to be the preferred routes for this amino acid to promote mucosal healing during and after cancer treatment.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32512833</pmid><doi>10.3390/nu12061675</doi><orcidid>https://orcid.org/0000-0002-0011-0969</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Antineoplastic Agents - adverse effects Cancer Cancer therapies Chemotherapy Cytokines Diet, High-Protein Dietary Proteins - administration & dosage Dietary Sucrose - administration & dosage Dietary Supplements Disaccharides Enteral nutrition Enteritis Esophagitis Esophagus Ewings sarcoma Glutamine Glutamine - administration & dosage Glutamine - metabolism Glutamine - pharmacology Healing High protein diet Humans Infections Inflammation Intestine Lymphocytes Malnutrition Malnutrition - etiology Medical prognosis Metabolism Mucosa Mucositis Mucositis - etiology Mucositis - physiopathology Mucositis - prevention & control Mucositis - therapy Mucous Membrane - metabolism Neoplasms - drug therapy Neoplasms - radiotherapy Nutrition Ostomy Pain management Parenteral nutrition Pharyngitis Quality of life Radiation Radiation damage Radiation therapy Radiotherapy - adverse effects Review Sarcopenia Small intestine Stomatitis Sucrose Sugar Transplants & implants Trehalose Trehalose - administration & dosage Tumors Wound Healing - drug effects |
| title | Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy |
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