Intra-Articular Route for the System of Molecules 14G1862 from Centella Asiatica : Pain Relieving and Protective Effects in a Rat Model of Osteoarthritis
Current pharmacological therapies for the management of chronic articular diseases are far from being satisfactory, so new strategies need to be investigated. We tested the intra-articular pain relieving properties of a system of molecules from a characterized extract (14G1862) in a rat model of ost...
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| Veröffentlicht in: | Nutrients 2020-05, Vol.12 (6), p.1618 |
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| creator | Micheli, Laura Di Cesare Mannelli, Lorenzo Mattoli, Luisa Tamimi, Sara Flamini, Enrico Garetto, Stefano Lucci, Jacopo Giovagnoni, Emiliano Cinci, Lorenzo D'Ambrosio, Mario Luceri, Cristina Ghelardini, Carla |
| description | Current pharmacological therapies for the management of chronic articular diseases are far from being satisfactory, so new strategies need to be investigated. We tested the intra-articular pain relieving properties of a system of molecules from a characterized
extract (14G1862) in a rat model of osteoarthritis induced by monoiodoacetate (MIA). 14G1862 (0.2-2 mg mL
) was intra-articularly (i.a.) injected 7 days after MIA, behavioural and histological evaluations were performed 14, 30 and 60 days after treatments. Moreover, the effect of 14G1862 on nitrate production and iNOS expression in RAW 264.7 macrophages stimulated with LPS was assessed.
, 14G1862 treatment attenuated LPS-induced NO production and iNOS expression in a comparable manner to celecoxib.
, 14G1862 significantly reduced mechanical allodynia and hyperalgesia, spontaneous pain and motor alterations starting on day 14 up to day 60. The efficacy was higher or comparable to that evoked by triamcinolone acetonide (100 μg i.a.) used as reference drug. Histological evaluation highlighted the improvement of several morphological parameters in MIA + 14G1862-treated animals with particularly benefic effects on joint space and fibrin deposition. In conclusion, i.a. treatment with
is a candidate to be a novel effective approach for osteoarthritis therapy. |
| doi_str_mv | 10.3390/nu12061618 |
| format | Article |
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extract (14G1862) in a rat model of osteoarthritis induced by monoiodoacetate (MIA). 14G1862 (0.2-2 mg mL
) was intra-articularly (i.a.) injected 7 days after MIA, behavioural and histological evaluations were performed 14, 30 and 60 days after treatments. Moreover, the effect of 14G1862 on nitrate production and iNOS expression in RAW 264.7 macrophages stimulated with LPS was assessed.
, 14G1862 treatment attenuated LPS-induced NO production and iNOS expression in a comparable manner to celecoxib.
, 14G1862 significantly reduced mechanical allodynia and hyperalgesia, spontaneous pain and motor alterations starting on day 14 up to day 60. The efficacy was higher or comparable to that evoked by triamcinolone acetonide (100 μg i.a.) used as reference drug. Histological evaluation highlighted the improvement of several morphological parameters in MIA + 14G1862-treated animals with particularly benefic effects on joint space and fibrin deposition. In conclusion, i.a. treatment with
is a candidate to be a novel effective approach for osteoarthritis therapy.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12061618</identifier><identifier>PMID: 32486519</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analgesics - pharmacology ; Analgesics - therapeutic use ; Animals ; Arthritis ; Arthritis, Experimental - chemically induced ; Arthritis, Experimental - drug therapy ; Biomedical materials ; Celecoxib ; Cell Survival - drug effects ; Centella - chemistry ; Centella asiatica ; Disease Models, Animal ; Ethanol ; Evaluation ; Fibrin ; Hyperalgesia ; Hyperalgesia - drug therapy ; Injections, Intra-Articular - methods ; Iodoacetic Acid ; Lipopolysaccharides ; Macrophages ; Macrophages - drug effects ; Male ; Mice ; Nitrates - metabolism ; Nitric Oxide Synthase Type II - metabolism ; Nitric-oxide synthase ; Nonsteroidal anti-inflammatory drugs ; Osteoarthritis ; Osteoarthritis - drug therapy ; Osteoarthritis, Knee - drug therapy ; Pain ; Pain - drug therapy ; Pain Management ; Pain perception ; Rats ; Rats, Sprague-Dawley ; RAW 264.7 Cells ; Reagents ; Triamcinolone acetonide ; Triterpenes - pharmacology ; Triterpenes - therapeutic use</subject><ispartof>Nutrients, 2020-05, Vol.12 (6), p.1618</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3218-40e3ac43ad20a29bae429cac3035d9c3cf773f5d1531af4a1bf2110296ad702c3</citedby><cites>FETCH-LOGICAL-c3218-40e3ac43ad20a29bae429cac3035d9c3cf773f5d1531af4a1bf2110296ad702c3</cites><orcidid>0000-0003-1232-8778 ; 0000-0001-8374-4432</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352185/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352185/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32486519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Micheli, Laura</creatorcontrib><creatorcontrib>Di Cesare Mannelli, Lorenzo</creatorcontrib><creatorcontrib>Mattoli, Luisa</creatorcontrib><creatorcontrib>Tamimi, Sara</creatorcontrib><creatorcontrib>Flamini, Enrico</creatorcontrib><creatorcontrib>Garetto, Stefano</creatorcontrib><creatorcontrib>Lucci, Jacopo</creatorcontrib><creatorcontrib>Giovagnoni, Emiliano</creatorcontrib><creatorcontrib>Cinci, Lorenzo</creatorcontrib><creatorcontrib>D'Ambrosio, Mario</creatorcontrib><creatorcontrib>Luceri, Cristina</creatorcontrib><creatorcontrib>Ghelardini, Carla</creatorcontrib><title>Intra-Articular Route for the System of Molecules 14G1862 from Centella Asiatica : Pain Relieving and Protective Effects in a Rat Model of Osteoarthritis</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Current pharmacological therapies for the management of chronic articular diseases are far from being satisfactory, so new strategies need to be investigated. We tested the intra-articular pain relieving properties of a system of molecules from a characterized
extract (14G1862) in a rat model of osteoarthritis induced by monoiodoacetate (MIA). 14G1862 (0.2-2 mg mL
) was intra-articularly (i.a.) injected 7 days after MIA, behavioural and histological evaluations were performed 14, 30 and 60 days after treatments. Moreover, the effect of 14G1862 on nitrate production and iNOS expression in RAW 264.7 macrophages stimulated with LPS was assessed.
, 14G1862 treatment attenuated LPS-induced NO production and iNOS expression in a comparable manner to celecoxib.
, 14G1862 significantly reduced mechanical allodynia and hyperalgesia, spontaneous pain and motor alterations starting on day 14 up to day 60. The efficacy was higher or comparable to that evoked by triamcinolone acetonide (100 μg i.a.) used as reference drug. Histological evaluation highlighted the improvement of several morphological parameters in MIA + 14G1862-treated animals with particularly benefic effects on joint space and fibrin deposition. In conclusion, i.a. treatment with
is a candidate to be a novel effective approach for osteoarthritis therapy.</description><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>Arthritis</subject><subject>Arthritis, Experimental - chemically induced</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Biomedical materials</subject><subject>Celecoxib</subject><subject>Cell Survival - drug effects</subject><subject>Centella - chemistry</subject><subject>Centella asiatica</subject><subject>Disease Models, Animal</subject><subject>Ethanol</subject><subject>Evaluation</subject><subject>Fibrin</subject><subject>Hyperalgesia</subject><subject>Hyperalgesia - drug therapy</subject><subject>Injections, Intra-Articular - methods</subject><subject>Iodoacetic Acid</subject><subject>Lipopolysaccharides</subject><subject>Macrophages</subject><subject>Macrophages - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Nitrates - 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pharmacology</topic><topic>Analgesics - therapeutic use</topic><topic>Animals</topic><topic>Arthritis</topic><topic>Arthritis, Experimental - chemically induced</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Biomedical materials</topic><topic>Celecoxib</topic><topic>Cell Survival - drug effects</topic><topic>Centella - chemistry</topic><topic>Centella asiatica</topic><topic>Disease Models, Animal</topic><topic>Ethanol</topic><topic>Evaluation</topic><topic>Fibrin</topic><topic>Hyperalgesia</topic><topic>Hyperalgesia - drug therapy</topic><topic>Injections, Intra-Articular - methods</topic><topic>Iodoacetic Acid</topic><topic>Lipopolysaccharides</topic><topic>Macrophages</topic><topic>Macrophages - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Nitrates - metabolism</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Nitric-oxide synthase</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - 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We tested the intra-articular pain relieving properties of a system of molecules from a characterized
extract (14G1862) in a rat model of osteoarthritis induced by monoiodoacetate (MIA). 14G1862 (0.2-2 mg mL
) was intra-articularly (i.a.) injected 7 days after MIA, behavioural and histological evaluations were performed 14, 30 and 60 days after treatments. Moreover, the effect of 14G1862 on nitrate production and iNOS expression in RAW 264.7 macrophages stimulated with LPS was assessed.
, 14G1862 treatment attenuated LPS-induced NO production and iNOS expression in a comparable manner to celecoxib.
, 14G1862 significantly reduced mechanical allodynia and hyperalgesia, spontaneous pain and motor alterations starting on day 14 up to day 60. The efficacy was higher or comparable to that evoked by triamcinolone acetonide (100 μg i.a.) used as reference drug. Histological evaluation highlighted the improvement of several morphological parameters in MIA + 14G1862-treated animals with particularly benefic effects on joint space and fibrin deposition. In conclusion, i.a. treatment with
is a candidate to be a novel effective approach for osteoarthritis therapy.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32486519</pmid><doi>10.3390/nu12061618</doi><orcidid>https://orcid.org/0000-0003-1232-8778</orcidid><orcidid>https://orcid.org/0000-0001-8374-4432</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2020-05, Vol.12 (6), p.1618 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Analgesics - pharmacology Analgesics - therapeutic use Animals Arthritis Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Biomedical materials Celecoxib Cell Survival - drug effects Centella - chemistry Centella asiatica Disease Models, Animal Ethanol Evaluation Fibrin Hyperalgesia Hyperalgesia - drug therapy Injections, Intra-Articular - methods Iodoacetic Acid Lipopolysaccharides Macrophages Macrophages - drug effects Male Mice Nitrates - metabolism Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Nonsteroidal anti-inflammatory drugs Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis, Knee - drug therapy Pain Pain - drug therapy Pain Management Pain perception Rats Rats, Sprague-Dawley RAW 264.7 Cells Reagents Triamcinolone acetonide Triterpenes - pharmacology Triterpenes - therapeutic use |
| title | Intra-Articular Route for the System of Molecules 14G1862 from Centella Asiatica : Pain Relieving and Protective Effects in a Rat Model of Osteoarthritis |
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