The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort)
Background The Geroscience field focuses on the core biological mechanisms of aging, which are involved in the onset of age-related diseases, as well as declines in intrinsic capacity (IC) (body functions) leading to dependency. A better understanding on how to measure the true age of an individual...
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| Veröffentlicht in: | The Journal of Frailty & Aging 2021, Vol.10 (2), p.110-120 |
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| container_title | The Journal of Frailty & Aging |
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| creator | Guyonnet, Sophie Rolland, Y. Takeda, C. Ousset, P.-J. Ader, I. Davezac, N. Dray, C. Fazilleau, N. Gourdy, P. Liblau, R. Parini, A. Payoux, P. Pénicaud, L. Rampon, C. Valet, P. Vergnolle, N. Andrieu, S. De Souto Barreto, P. Casteilla, L. Vellas, B. |
| description | Background
The Geroscience field focuses on the core biological mechanisms of aging, which are involved in the onset of age-related diseases, as well as declines in intrinsic capacity (IC) (body functions) leading to dependency. A better understanding on how to measure the true age of an individual or biological aging is an essential step that may lead to the definition of putative markers capable of predicting healthy aging.
Objectives
The main objective of the INStitute for Prevention healthy aging and medicine Rejuvenative (INSPIRE) Platform initiative is to build a program for Geroscience and healthy aging research going from animal models to humans and the health care system. The specific aim of the INSPIRE human translational cohort (INSPIRE-T cohort) is to gather clinical, digital and imaging data, and perform relevant and extensive biobanking to allow basic and translational research on humans.
Methods
The INSPIRE-T cohort consists in a population study comprising 1000 individuals in Toulouse and surrounding areas (France) of different ages (20 years or over — no upper limit for age) and functional capacity levels (from robustness to frailty, and even dependency) with follow-up over 10 years. Diversified data are collected annually in research facilities or at home according to standardized procedures. Between two annual visits, IC domains are monitored every 4-month by using the ICOPE Monitor app developed in collaboration with WHO. Once IC decline is confirmed, participants will have a clinical assessment and blood sampling to investigate markers of aging at the time IC declines are detected. Biospecimens include blood, urine, saliva, and dental plaque that are collected from all subjects at baseline and then, annually. Nasopharyngeal swabs and cutaneous surface samples are collected in a large subgroup of subjects every two years. Feces, hair bulb and skin biopsy are collected optionally at the baseline visit and will be performed again during the longitudinal follow up.
Expected Results
Recruitment started on October 2019 and is expected to last for two years. Bio-resources collected and explored in the INSPIRE-T cohort will be available for academic and industry partners aiming to identify robust (set of) markers of aging, age-related diseases and IC evolution that could be pharmacologically or non-pharmacologically targetable. The INSPIRE-T will also aim to develop an integrative approach to explore the use of innovative technologies and a ne |
| doi_str_mv | 10.14283/jfa.2020.38 |
| format | Article |
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The Geroscience field focuses on the core biological mechanisms of aging, which are involved in the onset of age-related diseases, as well as declines in intrinsic capacity (IC) (body functions) leading to dependency. A better understanding on how to measure the true age of an individual or biological aging is an essential step that may lead to the definition of putative markers capable of predicting healthy aging.
Objectives
The main objective of the INStitute for Prevention healthy aging and medicine Rejuvenative (INSPIRE) Platform initiative is to build a program for Geroscience and healthy aging research going from animal models to humans and the health care system. The specific aim of the INSPIRE human translational cohort (INSPIRE-T cohort) is to gather clinical, digital and imaging data, and perform relevant and extensive biobanking to allow basic and translational research on humans.
Methods
The INSPIRE-T cohort consists in a population study comprising 1000 individuals in Toulouse and surrounding areas (France) of different ages (20 years or over — no upper limit for age) and functional capacity levels (from robustness to frailty, and even dependency) with follow-up over 10 years. Diversified data are collected annually in research facilities or at home according to standardized procedures. Between two annual visits, IC domains are monitored every 4-month by using the ICOPE Monitor app developed in collaboration with WHO. Once IC decline is confirmed, participants will have a clinical assessment and blood sampling to investigate markers of aging at the time IC declines are detected. Biospecimens include blood, urine, saliva, and dental plaque that are collected from all subjects at baseline and then, annually. Nasopharyngeal swabs and cutaneous surface samples are collected in a large subgroup of subjects every two years. Feces, hair bulb and skin biopsy are collected optionally at the baseline visit and will be performed again during the longitudinal follow up.
Expected Results
Recruitment started on October 2019 and is expected to last for two years. Bio-resources collected and explored in the INSPIRE-T cohort will be available for academic and industry partners aiming to identify robust (set of) markers of aging, age-related diseases and IC evolution that could be pharmacologically or non-pharmacologically targetable. The INSPIRE-T will also aim to develop an integrative approach to explore the use of innovative technologies and a new, function and person-centered health care pathway that will promote a healthy aging.</description><identifier>ISSN: 2260-1341</identifier><identifier>EISSN: 2273-4309</identifier><identifier>DOI: 10.14283/jfa.2020.38</identifier><identifier>PMID: 33575699</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Age differences ; Aged ; Aged, 80 and over ; Aging ; Biological Specimen Banks ; Biomarkers ; Biopsy ; Blood tests ; Clinical assessment ; Cognition & reasoning ; Cohort Studies ; Collaboration ; Data collection ; Dependency ; Evolution ; Exercise ; Frailty ; France ; Functional status ; Geriatrics ; Geriatrics/Gerontology ; Geriatry and gerontology ; Hair ; Health care ; Healthy Aging ; Human health and pathology ; Humans ; Influenza ; Integrative approach ; Internal Medicine ; Life Sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Research ; R&D ; Recruitment ; Research & development ; Rheumatology ; Robustness ; Saliva ; Translational Research, Biomedical</subject><ispartof>The Journal of Frailty & Aging, 2021, Vol.10 (2), p.110-120</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-ded7403e1730ade3e797bd1a09c6d8d45fa06d238b98cac344ed13ea5908876b3</citedby><cites>FETCH-LOGICAL-c484t-ded7403e1730ade3e797bd1a09c6d8d45fa06d238b98cac344ed13ea5908876b3</cites><orcidid>0000-0002-1157-0215 ; 0000-0002-9848-8838 ; 0000-0002-1142-770X ; 0000-0003-1825-6015 ; 0009-0003-9486-9144 ; 0000-0001-8551-8682 ; 0000-0002-6034-6359 ; 0000-0002-3574-5614 ; 0000-0002-1374-1620 ; 0000-0002-8860-425X ; 0000-0002-7678-5065 ; 0000-0001-5477-5475</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2932844127?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,776,780,881,12825,21367,27901,27902,30976,33721,33722,43781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33575699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-03023578$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Guyonnet, Sophie</creatorcontrib><creatorcontrib>Rolland, Y.</creatorcontrib><creatorcontrib>Takeda, C.</creatorcontrib><creatorcontrib>Ousset, P.-J.</creatorcontrib><creatorcontrib>Ader, I.</creatorcontrib><creatorcontrib>Davezac, N.</creatorcontrib><creatorcontrib>Dray, C.</creatorcontrib><creatorcontrib>Fazilleau, N.</creatorcontrib><creatorcontrib>Gourdy, P.</creatorcontrib><creatorcontrib>Liblau, R.</creatorcontrib><creatorcontrib>Parini, A.</creatorcontrib><creatorcontrib>Payoux, P.</creatorcontrib><creatorcontrib>Pénicaud, L.</creatorcontrib><creatorcontrib>Rampon, C.</creatorcontrib><creatorcontrib>Valet, P.</creatorcontrib><creatorcontrib>Vergnolle, N.</creatorcontrib><creatorcontrib>Andrieu, S.</creatorcontrib><creatorcontrib>De Souto Barreto, P.</creatorcontrib><creatorcontrib>Casteilla, L.</creatorcontrib><creatorcontrib>Vellas, B.</creatorcontrib><title>The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort)</title><title>The Journal of Frailty & Aging</title><addtitle>J Frailty Aging</addtitle><addtitle>J Frailty Aging</addtitle><description>Background
The Geroscience field focuses on the core biological mechanisms of aging, which are involved in the onset of age-related diseases, as well as declines in intrinsic capacity (IC) (body functions) leading to dependency. A better understanding on how to measure the true age of an individual or biological aging is an essential step that may lead to the definition of putative markers capable of predicting healthy aging.
Objectives
The main objective of the INStitute for Prevention healthy aging and medicine Rejuvenative (INSPIRE) Platform initiative is to build a program for Geroscience and healthy aging research going from animal models to humans and the health care system. The specific aim of the INSPIRE human translational cohort (INSPIRE-T cohort) is to gather clinical, digital and imaging data, and perform relevant and extensive biobanking to allow basic and translational research on humans.
Methods
The INSPIRE-T cohort consists in a population study comprising 1000 individuals in Toulouse and surrounding areas (France) of different ages (20 years or over — no upper limit for age) and functional capacity levels (from robustness to frailty, and even dependency) with follow-up over 10 years. Diversified data are collected annually in research facilities or at home according to standardized procedures. Between two annual visits, IC domains are monitored every 4-month by using the ICOPE Monitor app developed in collaboration with WHO. Once IC decline is confirmed, participants will have a clinical assessment and blood sampling to investigate markers of aging at the time IC declines are detected. Biospecimens include blood, urine, saliva, and dental plaque that are collected from all subjects at baseline and then, annually. Nasopharyngeal swabs and cutaneous surface samples are collected in a large subgroup of subjects every two years. Feces, hair bulb and skin biopsy are collected optionally at the baseline visit and will be performed again during the longitudinal follow up.
Expected Results
Recruitment started on October 2019 and is expected to last for two years. Bio-resources collected and explored in the INSPIRE-T cohort will be available for academic and industry partners aiming to identify robust (set of) markers of aging, age-related diseases and IC evolution that could be pharmacologically or non-pharmacologically targetable. The INSPIRE-T will also aim to develop an integrative approach to explore the use of innovative technologies and a new, function and person-centered health care pathway that will promote a healthy aging.</description><subject>Adult</subject><subject>Age differences</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Biological Specimen Banks</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Blood tests</subject><subject>Clinical assessment</subject><subject>Cognition & reasoning</subject><subject>Cohort Studies</subject><subject>Collaboration</subject><subject>Data collection</subject><subject>Dependency</subject><subject>Evolution</subject><subject>Exercise</subject><subject>Frailty</subject><subject>France</subject><subject>Functional status</subject><subject>Geriatrics</subject><subject>Geriatrics/Gerontology</subject><subject>Geriatry and gerontology</subject><subject>Hair</subject><subject>Health care</subject><subject>Healthy Aging</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Influenza</subject><subject>Integrative approach</subject><subject>Internal Medicine</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Research</subject><subject>R&D</subject><subject>Recruitment</subject><subject>Research & development</subject><subject>Rheumatology</subject><subject>Robustness</subject><subject>Saliva</subject><subject>Translational Research, Biomedical</subject><issn>2260-1341</issn><issn>2273-4309</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>BENPR</sourceid><recordid>eNptksFuEzEQhlcIRKvQG2dkiUsrscH2eHdtDkghaptIEVQlnC3HO8lutbGLvVupD8L74pDQloqLbc18_see-bPsLaNjJriEjzdrM-aU0zHIF9kx5xXkAqh6uTuXNGcg2FF2EmO7okIpWTJgr7MjgKIqSqWOs1_LBsn86_er-fU5-dL6_BqjH4JFkg5ogm3IVWf6tQ9bkhYyQ9P1zT2ZbFq3IcbV5BKDj7ZFZ_ETufB2iMQ70ifZ2bA1jiyDcTFJtN6Z7lF16hsfenL6pH6-PETP3mSv1qaLeHLYR9mPi_PldJYvvl3Op5NFboUUfV5jXQkKyCqgpkbASlWrmhmqbFnLWhRrQ8uag1wpaY0FIbBmgKZQVMqqXMEo-7zXvR1WW6wtuj6YTt-GdmvCvfam1f9mXNvojb_TFRScSpEEzvYCzbNrs8lC72IUKE_NlncssaeHYsH_HDD2ettGi11nHPohai6k4oUAoAl9_wy9SUNJ_UuUAi6FYGnSo-zDnrJpAjHg-uEFjOo_9tDJHnpnDw0y4e-efvYB_muGBOR7IKaU22B4rPpfwd9YT8Ox</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Guyonnet, Sophie</creator><creator>Rolland, 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INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort)</title><author>Guyonnet, Sophie ; Rolland, Y. ; Takeda, C. ; Ousset, P.-J. ; Ader, I. ; Davezac, N. ; Dray, C. ; Fazilleau, N. ; Gourdy, P. ; Liblau, R. ; Parini, A. ; Payoux, P. ; Pénicaud, L. ; Rampon, C. ; Valet, P. ; Vergnolle, N. ; Andrieu, S. ; De Souto Barreto, P. ; Casteilla, L. ; Vellas, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-ded7403e1730ade3e797bd1a09c6d8d45fa06d238b98cac344ed13ea5908876b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Age differences</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Biological Specimen Banks</topic><topic>Biomarkers</topic><topic>Biopsy</topic><topic>Blood tests</topic><topic>Clinical assessment</topic><topic>Cognition & reasoning</topic><topic>Cohort Studies</topic><topic>Collaboration</topic><topic>Data collection</topic><topic>Dependency</topic><topic>Evolution</topic><topic>Exercise</topic><topic>Frailty</topic><topic>France</topic><topic>Functional status</topic><topic>Geriatrics</topic><topic>Geriatrics/Gerontology</topic><topic>Geriatry and gerontology</topic><topic>Hair</topic><topic>Health care</topic><topic>Healthy Aging</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Influenza</topic><topic>Integrative approach</topic><topic>Internal Medicine</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Research</topic><topic>R&D</topic><topic>Recruitment</topic><topic>Research & development</topic><topic>Rheumatology</topic><topic>Robustness</topic><topic>Saliva</topic><topic>Translational Research, Biomedical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guyonnet, Sophie</creatorcontrib><creatorcontrib>Rolland, Y.</creatorcontrib><creatorcontrib>Takeda, C.</creatorcontrib><creatorcontrib>Ousset, P.-J.</creatorcontrib><creatorcontrib>Ader, I.</creatorcontrib><creatorcontrib>Davezac, N.</creatorcontrib><creatorcontrib>Dray, C.</creatorcontrib><creatorcontrib>Fazilleau, N.</creatorcontrib><creatorcontrib>Gourdy, P.</creatorcontrib><creatorcontrib>Liblau, R.</creatorcontrib><creatorcontrib>Parini, A.</creatorcontrib><creatorcontrib>Payoux, P.</creatorcontrib><creatorcontrib>Pénicaud, L.</creatorcontrib><creatorcontrib>Rampon, C.</creatorcontrib><creatorcontrib>Valet, P.</creatorcontrib><creatorcontrib>Vergnolle, N.</creatorcontrib><creatorcontrib>Andrieu, S.</creatorcontrib><creatorcontrib>De Souto Barreto, P.</creatorcontrib><creatorcontrib>Casteilla, L.</creatorcontrib><creatorcontrib>Vellas, B.</creatorcontrib><collection>Springer 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Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of Frailty & Aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guyonnet, Sophie</au><au>Rolland, Y.</au><au>Takeda, C.</au><au>Ousset, P.-J.</au><au>Ader, I.</au><au>Davezac, N.</au><au>Dray, C.</au><au>Fazilleau, N.</au><au>Gourdy, P.</au><au>Liblau, R.</au><au>Parini, A.</au><au>Payoux, P.</au><au>Pénicaud, L.</au><au>Rampon, C.</au><au>Valet, P.</au><au>Vergnolle, N.</au><au>Andrieu, S.</au><au>De Souto Barreto, P.</au><au>Casteilla, L.</au><au>Vellas, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort)</atitle><jtitle>The Journal of Frailty & Aging</jtitle><stitle>J Frailty Aging</stitle><addtitle>J Frailty Aging</addtitle><date>2021</date><risdate>2021</risdate><volume>10</volume><issue>2</issue><spage>110</spage><epage>120</epage><pages>110-120</pages><issn>2260-1341</issn><eissn>2273-4309</eissn><abstract>Background
The Geroscience field focuses on the core biological mechanisms of aging, which are involved in the onset of age-related diseases, as well as declines in intrinsic capacity (IC) (body functions) leading to dependency. A better understanding on how to measure the true age of an individual or biological aging is an essential step that may lead to the definition of putative markers capable of predicting healthy aging.
Objectives
The main objective of the INStitute for Prevention healthy aging and medicine Rejuvenative (INSPIRE) Platform initiative is to build a program for Geroscience and healthy aging research going from animal models to humans and the health care system. The specific aim of the INSPIRE human translational cohort (INSPIRE-T cohort) is to gather clinical, digital and imaging data, and perform relevant and extensive biobanking to allow basic and translational research on humans.
Methods
The INSPIRE-T cohort consists in a population study comprising 1000 individuals in Toulouse and surrounding areas (France) of different ages (20 years or over — no upper limit for age) and functional capacity levels (from robustness to frailty, and even dependency) with follow-up over 10 years. Diversified data are collected annually in research facilities or at home according to standardized procedures. Between two annual visits, IC domains are monitored every 4-month by using the ICOPE Monitor app developed in collaboration with WHO. Once IC decline is confirmed, participants will have a clinical assessment and blood sampling to investigate markers of aging at the time IC declines are detected. Biospecimens include blood, urine, saliva, and dental plaque that are collected from all subjects at baseline and then, annually. Nasopharyngeal swabs and cutaneous surface samples are collected in a large subgroup of subjects every two years. Feces, hair bulb and skin biopsy are collected optionally at the baseline visit and will be performed again during the longitudinal follow up.
Expected Results
Recruitment started on October 2019 and is expected to last for two years. Bio-resources collected and explored in the INSPIRE-T cohort will be available for academic and industry partners aiming to identify robust (set of) markers of aging, age-related diseases and IC evolution that could be pharmacologically or non-pharmacologically targetable. The INSPIRE-T will also aim to develop an integrative approach to explore the use of innovative technologies and a new, function and person-centered health care pathway that will promote a healthy aging.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33575699</pmid><doi>10.14283/jfa.2020.38</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1157-0215</orcidid><orcidid>https://orcid.org/0000-0002-9848-8838</orcidid><orcidid>https://orcid.org/0000-0002-1142-770X</orcidid><orcidid>https://orcid.org/0000-0003-1825-6015</orcidid><orcidid>https://orcid.org/0009-0003-9486-9144</orcidid><orcidid>https://orcid.org/0000-0001-8551-8682</orcidid><orcidid>https://orcid.org/0000-0002-6034-6359</orcidid><orcidid>https://orcid.org/0000-0002-3574-5614</orcidid><orcidid>https://orcid.org/0000-0002-1374-1620</orcidid><orcidid>https://orcid.org/0000-0002-8860-425X</orcidid><orcidid>https://orcid.org/0000-0002-7678-5065</orcidid><orcidid>https://orcid.org/0000-0001-5477-5475</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2260-1341 |
| ispartof | The Journal of Frailty & Aging, 2021, Vol.10 (2), p.110-120 |
| issn | 2260-1341 2273-4309 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7352084 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Adult Age differences Aged Aged, 80 and over Aging Biological Specimen Banks Biomarkers Biopsy Blood tests Clinical assessment Cognition & reasoning Cohort Studies Collaboration Data collection Dependency Evolution Exercise Frailty France Functional status Geriatrics Geriatrics/Gerontology Geriatry and gerontology Hair Health care Healthy Aging Human health and pathology Humans Influenza Integrative approach Internal Medicine Life Sciences Medicine Medicine & Public Health Middle Aged Original Research R&D Recruitment Research & development Rheumatology Robustness Saliva Translational Research, Biomedical |
| title | The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T01%3A52%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20INSPIRE%20Bio-Resource%20Research%20Platform%20for%20Healthy%20Aging%20and%20Geroscience:%20Focus%20on%20the%20Human%20Translational%20Research%20Cohort%20(The%20INSPIRE-T%20Cohort)&rft.jtitle=The%20Journal%20of%20Frailty%20&%20Aging&rft.au=Guyonnet,%20Sophie&rft.date=2021&rft.volume=10&rft.issue=2&rft.spage=110&rft.epage=120&rft.pages=110-120&rft.issn=2260-1341&rft.eissn=2273-4309&rft_id=info:doi/10.14283/jfa.2020.38&rft_dat=%3Cproquest_pubme%3E2932844127%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2932844127&rft_id=info:pmid/33575699&rfr_iscdi=true |