PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties

Mesenchymal stem cell (MSC)-based therapy is being increasingly considered a powerful opportunity for several disorders based on MSC immunoregulatory properties. Nonetheless, MSC are versatile and plastic cells that require an efficient control of their features and functions for their optimal use i...

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Veröffentlicht in:	Scientific reports 2020-07, Vol.10 (1), p.11423-11423, Article 11423
Hauptverfasser:	Contreras-Lopez, R. A., Elizondo-Vega, R., Torres, M. J., Vega-Letter, A. M., Luque-Campos, N., Paredes-Martinez, M. J., Pradenas, C., Tejedor, G., Oyarce, K., Salgado, M., Jorgensen, C., Khoury, M., Kronke, G., Garcia-Robles, M. A., Altamirano, C., Luz-Crawford, P., Djouad, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/1898 631/532/2074 Animals Bone Marrow Cells - cytology CD4-Positive T-Lymphocytes - cytology Cell Proliferation Cellular Biology Gene Silencing Glycolysis Helper cells Humanities and Social Sciences Immunology Immunoregulation Immunosuppression Life Sciences Lymphocytes T Mesenchymal Stem Cells - metabolism Mesenchyme Metabolism Mice Mitochondria multidisciplinary Oligomycins - chemistry PPAR-beta - metabolism Receptors, Cytoplasmic and Nuclear - metabolism Science Science (multidisciplinary) Stem cells Th1 Cells - cytology Th17 Cells - cytology
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