A simple and cost-efficient technique to generate hyperpolarized long-lived 15N-15N nuclear spin order in a diazine by signal amplification by reversible exchange
Signal Amplification by Reversible Exchange (SABRE) is an inexpensive and simple hyperpolarization technique that is capable of boosting nuclear magnetic resonance sensitivity by several orders of magnitude. It utilizes the reversible binding of para-hydrogen, as hydride ligands, and a substrate of...
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description | Signal Amplification by Reversible Exchange (SABRE) is an inexpensive and simple hyperpolarization technique that is capable of boosting nuclear magnetic resonance sensitivity by several orders of magnitude. It utilizes the reversible binding of para-hydrogen, as hydride ligands, and a substrate of interest to a metal catalyst to allow for polarization transfer from para-hydrogen into substrate nuclear spins. While the resulting nuclear spin populations can be dramatically larger than those normally created, their lifetime sets a strict upper limit on the experimental timeframe. Consequently, short nuclear spin lifetimes are a challenge for hyperpolarized metabolic imaging. In this report, we demonstrate how both hyperpolarization and long nuclear spin lifetime can be simultaneously achieved in nitrogen-15 containing derivatives of pyridazine and phthalazine by SABRE. These substrates were chosen to reflect two distinct classes of 15N2-coupled species that differ according to their chemical symmetry and thereby achieve different nuclear spin lifetimes. The pyridazine derivative proves to exhibit a signal lifetime of ∼2.5 min and can be produced with a signal enhancement of ∼2700. In contrast, while the phthalazine derivative yields a superior 15 000-fold 15N signal enhancement at 11.7 T, it has a much shorter signal lifetime. |
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It utilizes the reversible binding of para-hydrogen, as hydride ligands, and a substrate of interest to a metal catalyst to allow for polarization transfer from para-hydrogen into substrate nuclear spins. While the resulting nuclear spin populations can be dramatically larger than those normally created, their lifetime sets a strict upper limit on the experimental timeframe. Consequently, short nuclear spin lifetimes are a challenge for hyperpolarized metabolic imaging. In this report, we demonstrate how both hyperpolarization and long nuclear spin lifetime can be simultaneously achieved in nitrogen-15 containing derivatives of pyridazine and phthalazine by SABRE. These substrates were chosen to reflect two distinct classes of 15N2-coupled species that differ according to their chemical symmetry and thereby achieve different nuclear spin lifetimes. The pyridazine derivative proves to exhibit a signal lifetime of ∼2.5 min and can be produced with a signal enhancement of ∼2700. In contrast, while the phthalazine derivative yields a superior 15 000-fold 15N signal enhancement at 11.7 T, it has a much shorter signal lifetime.</description><identifier>ISSN: 0021-9606</identifier><identifier>EISSN: 1089-7690</identifier><identifier>DOI: 10.1063/1.5132308</identifier><identifier>PMID: 31914733</identifier><identifier>CODEN: JCPSA6</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Amplification ; Exchanging ; Hydrogen storage ; Lifetime ; Nitrogen isotopes ; NMR ; Nuclear magnetic resonance ; Nuclear spin ; Organic chemistry ; Physics ; Substrates</subject><ispartof>The Journal of chemical physics, 2020-01, Vol.152 (1)</ispartof><rights>Author(s)</rights><rights>2020 Author(s). 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It utilizes the reversible binding of para-hydrogen, as hydride ligands, and a substrate of interest to a metal catalyst to allow for polarization transfer from para-hydrogen into substrate nuclear spins. While the resulting nuclear spin populations can be dramatically larger than those normally created, their lifetime sets a strict upper limit on the experimental timeframe. Consequently, short nuclear spin lifetimes are a challenge for hyperpolarized metabolic imaging. In this report, we demonstrate how both hyperpolarization and long nuclear spin lifetime can be simultaneously achieved in nitrogen-15 containing derivatives of pyridazine and phthalazine by SABRE. These substrates were chosen to reflect two distinct classes of 15N2-coupled species that differ according to their chemical symmetry and thereby achieve different nuclear spin lifetimes. The pyridazine derivative proves to exhibit a signal lifetime of ∼2.5 min and can be produced with a signal enhancement of ∼2700. In contrast, while the phthalazine derivative yields a superior 15 000-fold 15N signal enhancement at 11.7 T, it has a much shorter signal lifetime.</description><subject>Amplification</subject><subject>Exchanging</subject><subject>Hydrogen storage</subject><subject>Lifetime</subject><subject>Nitrogen isotopes</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear spin</subject><subject>Organic chemistry</subject><subject>Physics</subject><subject>Substrates</subject><issn>0021-9606</issn><issn>1089-7690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kc9q3DAQxkVpabZpD30DQU8tOJU0tmVdCiH0H4Tk0p6FLI29Cl7JlbxLNo_TJ62SXVJKIQehQfPj-0bfEPKWszPOWvjIzxoOAlj3jKw461QlW8WekxVjgleqZe0JeZXzDWOMS1G_JCfAFa8lwIr8PqfZb-YJqQmO2piXCofBW49hoQvadfC_tkiXSEcMmMyCdL2fMc1xMsnfoaNTDGM1-V0peXNVlUPD1k5oEs2zDzQmh4mWwlDnzZ0PSPt9MR2Dmagp1r7YmcXHcP-ecIcp-74MhLd2bcKIr8mLwUwZ3xzvU_Lzy-cfF9-qy-uv3y_OLysrVNNVTqh6sHWDTV-3KFrmoHVisKw0JXaut4PrJXR1DzgoC6AMOJQGOIrOgoNT8umgO2_7DTpbEkhm0nPyG5P2Ohqv_-0Ev9Zj3GkJDReCF4F3R4EUS2h50Tdxm8o3sxYAvFMgmSzU-wNlU8w54fDowJm-X6fm-rjOwn44sNn65SGjR3gX019Qz254Cv5f-Q8JrbA2</recordid><startdate>20200107</startdate><enddate>20200107</enddate><creator>Roy, Soumya S.</creator><creator>Rayner, Peter J.</creator><creator>Burns, Michael J.</creator><creator>Duckett, Simon B.</creator><general>American Institute of Physics</general><general>AIP Publishing LLC</general><scope>AJDQP</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9193-9712</orcidid><orcidid>https://orcid.org/0000-0002-9788-6615</orcidid><orcidid>https://orcid.org/0000-0002-6577-4117</orcidid></search><sort><creationdate>20200107</creationdate><title>A simple and cost-efficient technique to generate hyperpolarized long-lived 15N-15N nuclear spin order in a diazine by signal amplification by reversible exchange</title><author>Roy, Soumya S. ; Rayner, Peter J. ; Burns, Michael J. ; Duckett, Simon B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2958-d294fc45e5b46e260d36d2fc09587e8dbcfdb7384b3ef9c339a3de7a31e28c3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amplification</topic><topic>Exchanging</topic><topic>Hydrogen storage</topic><topic>Lifetime</topic><topic>Nitrogen isotopes</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nuclear spin</topic><topic>Organic chemistry</topic><topic>Physics</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roy, Soumya S.</creatorcontrib><creatorcontrib>Rayner, Peter J.</creatorcontrib><creatorcontrib>Burns, Michael J.</creatorcontrib><creatorcontrib>Duckett, Simon B.</creatorcontrib><collection>AIP Open Access Journals</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of chemical physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roy, Soumya S.</au><au>Rayner, Peter J.</au><au>Burns, Michael J.</au><au>Duckett, Simon B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A simple and cost-efficient technique to generate hyperpolarized long-lived 15N-15N nuclear spin order in a diazine by signal amplification by reversible exchange</atitle><jtitle>The Journal of chemical physics</jtitle><date>2020-01-07</date><risdate>2020</risdate><volume>152</volume><issue>1</issue><issn>0021-9606</issn><eissn>1089-7690</eissn><coden>JCPSA6</coden><abstract>Signal Amplification by Reversible Exchange (SABRE) is an inexpensive and simple hyperpolarization technique that is capable of boosting nuclear magnetic resonance sensitivity by several orders of magnitude. It utilizes the reversible binding of para-hydrogen, as hydride ligands, and a substrate of interest to a metal catalyst to allow for polarization transfer from para-hydrogen into substrate nuclear spins. While the resulting nuclear spin populations can be dramatically larger than those normally created, their lifetime sets a strict upper limit on the experimental timeframe. Consequently, short nuclear spin lifetimes are a challenge for hyperpolarized metabolic imaging. In this report, we demonstrate how both hyperpolarization and long nuclear spin lifetime can be simultaneously achieved in nitrogen-15 containing derivatives of pyridazine and phthalazine by SABRE. These substrates were chosen to reflect two distinct classes of 15N2-coupled species that differ according to their chemical symmetry and thereby achieve different nuclear spin lifetimes. The pyridazine derivative proves to exhibit a signal lifetime of ∼2.5 min and can be produced with a signal enhancement of ∼2700. 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subjects | Amplification Exchanging Hydrogen storage Lifetime Nitrogen isotopes NMR Nuclear magnetic resonance Nuclear spin Organic chemistry Physics Substrates |
title | A simple and cost-efficient technique to generate hyperpolarized long-lived 15N-15N nuclear spin order in a diazine by signal amplification by reversible exchange |
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