UHRF1 predicts poor prognosis by triggering cell cycle in lung adenocarcinoma
Accumulating evidence suggests that ubiquitin‐like with plant homeodomain and ring finger domains 1 (UHRF1) is overexpressed in non‐small cell lung cancer (NSCLC); however, the expression and function of UHRF1 in the subtype of NSCLC are still unclear. Here, we investigate the expression and prognos...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2020-07, Vol.24 (14), p.8069-8077 |
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| description | Accumulating evidence suggests that ubiquitin‐like with plant homeodomain and ring finger domains 1 (UHRF1) is overexpressed in non‐small cell lung cancer (NSCLC); however, the expression and function of UHRF1 in the subtype of NSCLC are still unclear. Here, we investigate the expression and prognosis traits of UHRF1 in large NSCLC cohorts and explore the molecular characters during UHRF1 up‐regulation. We find that UHRF1 is predominantly overexpressed in lung squamous cell carcinoma (SCC). Surprisingly, the up‐regulated UHRF1 is only associated with the overall survival of lung adenocarcinoma (ADC) and knockdown of UHRF1 dramatically attenuates ADC tumorigenesis. Mechanically, we identify a hub gene that includes a total of 55 UHRF1‐related genes, which are tightly associated with cell cycle pathway and yield to the poor clinical outcome in ADC patients. What's more, we observe knockdown of UHRF1 only affects ADC cells cycle and induces cell apoptosis. These results suggest that up‐regulated UHRF1 only contributes to lung ADC survival by triggering cell cycle pathway, and it may be a prognostic biomarker for lung ADC patients. |
| doi_str_mv | 10.1111/jcmm.15438 |
| format | Article |
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Here, we investigate the expression and prognosis traits of UHRF1 in large NSCLC cohorts and explore the molecular characters during UHRF1 up‐regulation. We find that UHRF1 is predominantly overexpressed in lung squamous cell carcinoma (SCC). Surprisingly, the up‐regulated UHRF1 is only associated with the overall survival of lung adenocarcinoma (ADC) and knockdown of UHRF1 dramatically attenuates ADC tumorigenesis. Mechanically, we identify a hub gene that includes a total of 55 UHRF1‐related genes, which are tightly associated with cell cycle pathway and yield to the poor clinical outcome in ADC patients. What's more, we observe knockdown of UHRF1 only affects ADC cells cycle and induces cell apoptosis. These results suggest that up‐regulated UHRF1 only contributes to lung ADC survival by triggering cell cycle pathway, and it may be a prognostic biomarker for lung ADC patients.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.15438</identifier><identifier>PMID: 32495469</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adenocarcinoma ; Adenocarcinoma of Lung - genetics ; Adenocarcinoma of Lung - mortality ; Adenocarcinoma of Lung - pathology ; Apoptosis ; Biomarkers, Tumor ; CCAAT-Enhancer-Binding Proteins - genetics ; Cell adhesion & migration ; Cell cycle ; Cell Cycle - genetics ; Cell Line, Tumor ; Cell survival ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Computational Biology - methods ; Datasets ; DNA methylation ; Gene Expression ; Gene Expression Profiling ; Gene Knockdown Techniques ; Homeobox ; Humans ; Kaplan-Meier Estimate ; lung adenocarcinoma ; Lung cancer ; Lung carcinoma ; Medical prognosis ; Metastasis ; Non-small cell lung carcinoma ; non‐small cell lung cancer ; Original ; Prognosis ; Small cell lung carcinoma ; Squamous cell carcinoma ; Survival analysis ; Tumorigenesis ; Ubiquitin ; Ubiquitin-Protein Ligases - genetics ; ubiquitin‐like with plant homeodomain and ring finger domains 1</subject><ispartof>Journal of cellular and molecular medicine, 2020-07, Vol.24 (14), p.8069-8077</ispartof><rights>2020 The Authors. published by Foundation for Cellular and Molecular Medicine and and John Wiley & Sons Ltd</rights><rights>2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and and John Wiley & Sons Ltd.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Here, we investigate the expression and prognosis traits of UHRF1 in large NSCLC cohorts and explore the molecular characters during UHRF1 up‐regulation. We find that UHRF1 is predominantly overexpressed in lung squamous cell carcinoma (SCC). Surprisingly, the up‐regulated UHRF1 is only associated with the overall survival of lung adenocarcinoma (ADC) and knockdown of UHRF1 dramatically attenuates ADC tumorigenesis. Mechanically, we identify a hub gene that includes a total of 55 UHRF1‐related genes, which are tightly associated with cell cycle pathway and yield to the poor clinical outcome in ADC patients. What's more, we observe knockdown of UHRF1 only affects ADC cells cycle and induces cell apoptosis. These results suggest that up‐regulated UHRF1 only contributes to lung ADC survival by triggering cell cycle pathway, and it may be a prognostic biomarker for lung ADC patients.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma of Lung - genetics</subject><subject>Adenocarcinoma of Lung - mortality</subject><subject>Adenocarcinoma of Lung - pathology</subject><subject>Apoptosis</subject><subject>Biomarkers, Tumor</subject><subject>CCAAT-Enhancer-Binding Proteins - genetics</subject><subject>Cell adhesion & migration</subject><subject>Cell cycle</subject><subject>Cell Cycle - genetics</subject><subject>Cell Line, Tumor</subject><subject>Cell survival</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Computational Biology - methods</subject><subject>Datasets</subject><subject>DNA methylation</subject><subject>Gene Expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Knockdown Techniques</subject><subject>Homeobox</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>lung adenocarcinoma</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Non-small cell lung carcinoma</subject><subject>non‐small cell lung cancer</subject><subject>Original</subject><subject>Prognosis</subject><subject>Small cell lung carcinoma</subject><subject>Squamous cell carcinoma</subject><subject>Survival analysis</subject><subject>Tumorigenesis</subject><subject>Ubiquitin</subject><subject>Ubiquitin-Protein Ligases - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tu, Zhenbo</au><au>Deng, Xinzhou</au><au>Hou, Shengqi</au><au>Feng, Anlin</au><au>Zhang, Qiuping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UHRF1 predicts poor prognosis by triggering cell cycle in lung adenocarcinoma</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2020-07</date><risdate>2020</risdate><volume>24</volume><issue>14</issue><spage>8069</spage><epage>8077</epage><pages>8069-8077</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>Accumulating evidence suggests that ubiquitin‐like with plant homeodomain and ring finger domains 1 (UHRF1) is overexpressed in non‐small cell lung cancer (NSCLC); however, the expression and function of UHRF1 in the subtype of NSCLC are still unclear. Here, we investigate the expression and prognosis traits of UHRF1 in large NSCLC cohorts and explore the molecular characters during UHRF1 up‐regulation. We find that UHRF1 is predominantly overexpressed in lung squamous cell carcinoma (SCC). Surprisingly, the up‐regulated UHRF1 is only associated with the overall survival of lung adenocarcinoma (ADC) and knockdown of UHRF1 dramatically attenuates ADC tumorigenesis. Mechanically, we identify a hub gene that includes a total of 55 UHRF1‐related genes, which are tightly associated with cell cycle pathway and yield to the poor clinical outcome in ADC patients. What's more, we observe knockdown of UHRF1 only affects ADC cells cycle and induces cell apoptosis. These results suggest that up‐regulated UHRF1 only contributes to lung ADC survival by triggering cell cycle pathway, and it may be a prognostic biomarker for lung ADC patients.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>32495469</pmid><doi>10.1111/jcmm.15438</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3720-7844</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - mortality Adenocarcinoma of Lung - pathology Apoptosis Biomarkers, Tumor CCAAT-Enhancer-Binding Proteins - genetics Cell adhesion & migration Cell cycle Cell Cycle - genetics Cell Line, Tumor Cell survival Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Computational Biology - methods Datasets DNA methylation Gene Expression Gene Expression Profiling Gene Knockdown Techniques Homeobox Humans Kaplan-Meier Estimate lung adenocarcinoma Lung cancer Lung carcinoma Medical prognosis Metastasis Non-small cell lung carcinoma non‐small cell lung cancer Original Prognosis Small cell lung carcinoma Squamous cell carcinoma Survival analysis Tumorigenesis Ubiquitin Ubiquitin-Protein Ligases - genetics ubiquitin‐like with plant homeodomain and ring finger domains 1 |
| title | UHRF1 predicts poor prognosis by triggering cell cycle in lung adenocarcinoma |
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