Plac8‐mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway

To explore the relationship between autophagy and cell function, we investigated how PLAC8‐mediated autophagy influences proliferation, apoptosis and epithelial‐mesenchymal transition (EMT) in NPC. Colony formation analyses and CCK8 assays were used to assess the proliferative capacity of NPC cells....

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-07, Vol.24 (14), p.7778-7788
Hauptverfasser:	Huang, Mao‐Ling, Qi, Cheng‐Lin, Zou, You, Yang, Rui, Jiang, Yang, Sheng, Jian‐Fei, Kong, Yong‐Gang, Tao, Ze‐Zhang, Chen, Shi‐Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein AKT/mTOR pathway Animals Antibodies Apoptosis Apoptosis - genetics Autophagy Autophagy - genetics Beclin-1 - genetics Beclin-1 - metabolism Cancer Cell adhesion & migration Cell cycle Cell growth Cell Line, Tumor Cell Proliferation Chemotherapy Disease Models, Animal Disease Susceptibility Epithelial-Mesenchymal Transition - genetics epithelial‐mesenchymal transition Experiments Flow cytometry Gene Knockdown Techniques Genes Humans Immunofluorescence Immunohistochemistry Immunoprecipitation Laboratory animals Male Membranes Mesenchyme Metastasis Mice Models, Biological Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - etiology Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Original Phagocytosis Phagosomes Phosphorylation placenta specific 8 gene knockout Proteins Proteins - genetics Proteins - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - genetics Signal Transduction Software Throat cancer TOR protein TOR Serine-Threonine Kinases - metabolism Transmission electron microscopy Xenografts
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