The effect of high-frequency oscillatory ventilation or airway pressure release ventilation on children with acute respiratory distress syndrome as a rescue therapy
To investigate the effects of high-frequency oscillatory ventilation (HFOV) or airway pressure release ventilation (APRV) as a rescue therapy on children with moderate and severe acute respiratory distress syndrome (ARDS). We retrospectively enrolled 47 children with ARDS who were transitioned from...
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| Veröffentlicht in: | Translational pediatrics 2020-06, Vol.9 (3), p.213-220 |
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| creator | Ning, Botao Liang, Lingfang Lyu, Yi Yu, Ying Li, Biru |
| description | To investigate the effects of high-frequency oscillatory ventilation (HFOV) or airway pressure release ventilation (APRV) as a rescue therapy on children with moderate and severe acute respiratory distress syndrome (ARDS).
We retrospectively enrolled 47 children with ARDS who were transitioned from synchronized intermittent mandatory ventilation (SIMV) to either HFOV or APRV for 48 h or longer after failure of SIMV. The parameters of demographic data, arterial blood gases, ventilator settings, oxygenation index (OI), and PaO
/FiO
(PF) ratio during the first 48 h of HFOV and APRV were recorded.
There was no significant difference between the HFOV and APRV groups with survival rates of 60% and 72.7%, respectively. Compared to pre-transition, the mean airway pressures at 2 and 48 h after transition were higher in both groups (P |
| doi_str_mv | 10.21037/tp-19-178 |
| format | Article |
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We retrospectively enrolled 47 children with ARDS who were transitioned from synchronized intermittent mandatory ventilation (SIMV) to either HFOV or APRV for 48 h or longer after failure of SIMV. The parameters of demographic data, arterial blood gases, ventilator settings, oxygenation index (OI), and PaO
/FiO
(PF) ratio during the first 48 h of HFOV and APRV were recorded.
There was no significant difference between the HFOV and APRV groups with survival rates of 60% and 72.7%, respectively. Compared to pre-transition, the mean airway pressures at 2 and 48 h after transition were higher in both groups (P<0.01), and the PF ratio at 2 and 48 h in both modes was significantly improved (P<0.001). PF ratio and PaCO
have significant differences at 48 h between two groups. The OI at 2 h after transition had no improvement in either group and was substantially lower at 48 h relative to the pre-transition level (P<0.001) in both groups. At 48 h after the transition to both HFOV and APRV, the survivors had lower mean airway pressures, higher PF ratios, and a lower OIs than non-survivors (P<0.01).
There was no significant difference on the survival rates of HFOV and APRV application as a rescue therapy for ARDS, but improved oxygenation at 48 h reliably discriminated survivors from non-survivors in both groups.</description><identifier>ISSN: 2224-4344</identifier><identifier>ISSN: 2224-4336</identifier><identifier>EISSN: 2224-4344</identifier><identifier>DOI: 10.21037/tp-19-178</identifier><identifier>PMID: 32775239</identifier><language>eng</language><publisher>China: AME Publishing Company</publisher><subject>Original</subject><ispartof>Translational pediatrics, 2020-06, Vol.9 (3), p.213-220</ispartof><rights>2020 Translational Pediatrics. All rights reserved.</rights><rights>2020 Translational Pediatrics. All rights reserved. 2020 Translational Pediatrics.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-6d33c349be29665fb94bb559e6f2c934d7a00d72fecaaacde687cdaf7a0bb6c23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347764/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347764/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32775239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ning, Botao</creatorcontrib><creatorcontrib>Liang, Lingfang</creatorcontrib><creatorcontrib>Lyu, Yi</creatorcontrib><creatorcontrib>Yu, Ying</creatorcontrib><creatorcontrib>Li, Biru</creatorcontrib><title>The effect of high-frequency oscillatory ventilation or airway pressure release ventilation on children with acute respiratory distress syndrome as a rescue therapy</title><title>Translational pediatrics</title><addtitle>Transl Pediatr</addtitle><description>To investigate the effects of high-frequency oscillatory ventilation (HFOV) or airway pressure release ventilation (APRV) as a rescue therapy on children with moderate and severe acute respiratory distress syndrome (ARDS).
We retrospectively enrolled 47 children with ARDS who were transitioned from synchronized intermittent mandatory ventilation (SIMV) to either HFOV or APRV for 48 h or longer after failure of SIMV. The parameters of demographic data, arterial blood gases, ventilator settings, oxygenation index (OI), and PaO
/FiO
(PF) ratio during the first 48 h of HFOV and APRV were recorded.
There was no significant difference between the HFOV and APRV groups with survival rates of 60% and 72.7%, respectively. Compared to pre-transition, the mean airway pressures at 2 and 48 h after transition were higher in both groups (P<0.01), and the PF ratio at 2 and 48 h in both modes was significantly improved (P<0.001). PF ratio and PaCO
have significant differences at 48 h between two groups. The OI at 2 h after transition had no improvement in either group and was substantially lower at 48 h relative to the pre-transition level (P<0.001) in both groups. At 48 h after the transition to both HFOV and APRV, the survivors had lower mean airway pressures, higher PF ratios, and a lower OIs than non-survivors (P<0.01).
There was no significant difference on the survival rates of HFOV and APRV application as a rescue therapy for ARDS, but improved oxygenation at 48 h reliably discriminated survivors from non-survivors in both groups.</description><subject>Original</subject><issn>2224-4344</issn><issn>2224-4336</issn><issn>2224-4344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkctq3TAQhkVpaUKaTR-gaFkKTq2LpeNNoYReAoFu0rUYS6NYxcdyJTnB79MHrU5PGpKVBunj08z8hLxl7QVnrdAfy9KwvmF694Kccs5lI4WUL5_UJ-Q8519t2zLVMcb5a3IiuNYdF_0p-XMzIkXv0RYaPR3D7dj4hL9XnO1GY7ZhmqDEtNE7nEuodYgzjYlCSPew0SVhzmtCmnBCyPgcm6kdw-QSzvQ-lJGCXcsBzUtIR6sLuRwUNG-zS3GPFDKFA2JXpGXEBMv2hrzyMGU8fzjPyM-vX24uvzfXP75dXX6-bqzQu9IoJ4QVsh-Q90p1fujlMHRdj8pz2wvpNLSt07wOCwDWodpp68DX62FQlosz8unoXdZhj87WURJMZklhD2kzEYJ5_jKH0dzGO6OF1FrJKnj_IEixrjAXsw_ZYl3hjHHNhkvBd0oL1lX0wxG1Keac0D9-w1rzL1lTFsN6U5Ot8LunjT2i_3MUfwH5U6Yi</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Ning, Botao</creator><creator>Liang, Lingfang</creator><creator>Lyu, Yi</creator><creator>Yu, Ying</creator><creator>Li, Biru</creator><general>AME Publishing Company</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202006</creationdate><title>The effect of high-frequency oscillatory ventilation or airway pressure release ventilation on children with acute respiratory distress syndrome as a rescue therapy</title><author>Ning, Botao ; Liang, Lingfang ; Lyu, Yi ; Yu, Ying ; Li, Biru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-6d33c349be29665fb94bb559e6f2c934d7a00d72fecaaacde687cdaf7a0bb6c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Ning, Botao</creatorcontrib><creatorcontrib>Liang, Lingfang</creatorcontrib><creatorcontrib>Lyu, Yi</creatorcontrib><creatorcontrib>Yu, Ying</creatorcontrib><creatorcontrib>Li, Biru</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ning, Botao</au><au>Liang, Lingfang</au><au>Lyu, Yi</au><au>Yu, Ying</au><au>Li, Biru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of high-frequency oscillatory ventilation or airway pressure release ventilation on children with acute respiratory distress syndrome as a rescue therapy</atitle><jtitle>Translational pediatrics</jtitle><addtitle>Transl Pediatr</addtitle><date>2020-06</date><risdate>2020</risdate><volume>9</volume><issue>3</issue><spage>213</spage><epage>220</epage><pages>213-220</pages><issn>2224-4344</issn><issn>2224-4336</issn><eissn>2224-4344</eissn><abstract>To investigate the effects of high-frequency oscillatory ventilation (HFOV) or airway pressure release ventilation (APRV) as a rescue therapy on children with moderate and severe acute respiratory distress syndrome (ARDS).
We retrospectively enrolled 47 children with ARDS who were transitioned from synchronized intermittent mandatory ventilation (SIMV) to either HFOV or APRV for 48 h or longer after failure of SIMV. The parameters of demographic data, arterial blood gases, ventilator settings, oxygenation index (OI), and PaO
/FiO
(PF) ratio during the first 48 h of HFOV and APRV were recorded.
There was no significant difference between the HFOV and APRV groups with survival rates of 60% and 72.7%, respectively. Compared to pre-transition, the mean airway pressures at 2 and 48 h after transition were higher in both groups (P<0.01), and the PF ratio at 2 and 48 h in both modes was significantly improved (P<0.001). PF ratio and PaCO
have significant differences at 48 h between two groups. The OI at 2 h after transition had no improvement in either group and was substantially lower at 48 h relative to the pre-transition level (P<0.001) in both groups. At 48 h after the transition to both HFOV and APRV, the survivors had lower mean airway pressures, higher PF ratios, and a lower OIs than non-survivors (P<0.01).
There was no significant difference on the survival rates of HFOV and APRV application as a rescue therapy for ARDS, but improved oxygenation at 48 h reliably discriminated survivors from non-survivors in both groups.</abstract><cop>China</cop><pub>AME Publishing Company</pub><pmid>32775239</pmid><doi>10.21037/tp-19-178</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Original |
| title | The effect of high-frequency oscillatory ventilation or airway pressure release ventilation on children with acute respiratory distress syndrome as a rescue therapy |
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