Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure
Noncoding RNAs (ncRNAs) are broadly described as RNA molecules that are not translated into protein. The investigation of dysregulated ncRNAs in human diseases such as cancer, neurological, and cardiovascular diseases has been under way for well over a decade. Micro-RNAs and long noncoding RNAs (lnc...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2020-05, Vol.318 (5), p.H1308-H1315 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
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| creator | Toni, Lee S Hailu, Frehiwet Sucharov, Carmen C |
| description | Noncoding RNAs (ncRNAs) are broadly described as RNA molecules that are not translated into protein. The investigation of dysregulated ncRNAs in human diseases such as cancer, neurological, and cardiovascular diseases has been under way for well over a decade. Micro-RNAs and long noncoding RNAs (lncRNAs) are the best characterized ncRNAs. These ncRNAs can have profound effects on the regulation of gene expression during cardiac development and disease. Importantly, ncRNAs are significant regulators of gene expression in several congenital heart diseases and can positively or negatively impact cardiovascular development. In this review, we focus on literature involving micro-RNAs and lncRNAs in the context of pediatric cardiovascular diseases, preclinical models of heart failure, and cardiac development. |
| doi_str_mv | 10.1152/ajpheart.00511.2019 |
| format | Article |
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In this review, we focus on literature involving micro-RNAs and lncRNAs in the context of pediatric cardiovascular diseases, preclinical models of heart failure, and cardiac development.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.00511.2019</identifier><identifier>PMID: 32216613</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Animals ; Gene Expression Regulation, Developmental ; Heart - embryology ; Heart Defects, Congenital - genetics ; Heart Defects, Congenital - metabolism ; Heart Defects, Congenital - pathology ; Heart Failure - genetics ; Heart Failure - metabolism ; Heart Failure - pathology ; Humans ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Mini Review ; Myocardium - metabolism ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism</subject><ispartof>American journal of physiology. 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Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>Noncoding RNAs (ncRNAs) are broadly described as RNA molecules that are not translated into protein. The investigation of dysregulated ncRNAs in human diseases such as cancer, neurological, and cardiovascular diseases has been under way for well over a decade. Micro-RNAs and long noncoding RNAs (lncRNAs) are the best characterized ncRNAs. These ncRNAs can have profound effects on the regulation of gene expression during cardiac development and disease. Importantly, ncRNAs are significant regulators of gene expression in several congenital heart diseases and can positively or negatively impact cardiovascular development. In this review, we focus on literature involving micro-RNAs and lncRNAs in the context of pediatric cardiovascular diseases, preclinical models of heart failure, and cardiac development.</description><subject>Animals</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Heart - embryology</subject><subject>Heart Defects, Congenital - genetics</subject><subject>Heart Defects, Congenital - metabolism</subject><subject>Heart Defects, Congenital - pathology</subject><subject>Heart Failure - genetics</subject><subject>Heart Failure - metabolism</subject><subject>Heart Failure - pathology</subject><subject>Humans</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Mini Review</subject><subject>Myocardium - metabolism</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1LxDAQDaLouvoLBOnRS9d8NGl7EcRvEAXRc0iT6Rppm5q0C_57s3VX9DTDvDdvHvMQOiF4QQin5-qjfwflhwXGnJAFxaTcQbOI0JRwVu6iGWaCpYIwfoAOQ_jAkZgLto8OGKVERGCGquuv4GE5NmoAk7RWe5e-PF2GRHUmaVy3TDrXaWds7Ka57RKtvLFKJwZW0Li-hW6Y6D3E8eCtTiZfSa1sM3o4Qnu1agIcb-ocvd3evF7dp4_Pdw9Xl4-pzjAf0poVKs9JXlNTlxxyrkERVmrNwRhWEMrKkmBRl5kArXJdQUVro4WoDOcsU2yOLn50-7Fqwehoy6tG9t62yn9Jp6z8j3T2XS7dSuYsEzzDUeBsI-Dd5whhkK0NGppGdeDGICkrMkpwQcpIZT_U-K8QH1j_niFYrtOR23TklI5cpxO3Tv86_N3ZxsG-Aa07j_A</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Toni, Lee S</creator><creator>Hailu, Frehiwet</creator><creator>Sucharov, Carmen C</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200501</creationdate><title>Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure</title><author>Toni, Lee S ; Hailu, Frehiwet ; Sucharov, Carmen C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-f38a7717f2df95e75cea139cc5edd3812399106f946eca7cbeb2fdc66bd5534a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Heart - embryology</topic><topic>Heart Defects, Congenital - genetics</topic><topic>Heart Defects, Congenital - metabolism</topic><topic>Heart Defects, Congenital - pathology</topic><topic>Heart Failure - genetics</topic><topic>Heart Failure - metabolism</topic><topic>Heart Failure - pathology</topic><topic>Humans</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Mini Review</topic><topic>Myocardium - metabolism</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toni, Lee S</creatorcontrib><creatorcontrib>Hailu, Frehiwet</creatorcontrib><creatorcontrib>Sucharov, Carmen C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of physiology. 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| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2020-05, Vol.318 (5), p.H1308-H1315 |
| issn | 0363-6135 1522-1539 |
| language | eng |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Gene Expression Regulation, Developmental Heart - embryology Heart Defects, Congenital - genetics Heart Defects, Congenital - metabolism Heart Defects, Congenital - pathology Heart Failure - genetics Heart Failure - metabolism Heart Failure - pathology Humans MicroRNAs - genetics MicroRNAs - metabolism Mini Review Myocardium - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism |
| title | Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure |
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