The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression
A high-fat diet and sedentary lifestyle could accelerate aging and hypothalamic inflammation. In order to explore the regulatory mechanisms of lifestyle in the hypothalamus, swimming exercise and diet control were applied in the high-fat diet ApoE-/- mice in our study. 20-week-old ApoE-/- mice fed w...
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| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2020-06, Vol.12 (11), p.11085-11099 |
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| container_issue | 11 |
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| container_title | Aging (Albany, NY.) |
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| creator | Wang, Xialei Yang, Jingda Lu, Taotao Zhan, Zengtu Wei, Wei Lyu, Xinru Jiang, Yijing Xue, Xiehua |
| description | A high-fat diet and sedentary lifestyle could accelerate aging and hypothalamic inflammation. In order to explore the regulatory mechanisms of lifestyle in the hypothalamus, swimming exercise and diet control were applied in the high-fat diet ApoE-/- mice in our study. 20-week-old ApoE-/- mice fed with 12-week high-fat diet were treated by high-fat diet, diet control and swimming exercise. The results showed that hypothalamic inflammation, glial cells activation and cognition decline were induced by high-fat diet. Compared with the diet control, hypothalamic inflammation, glial cells activation and learning and memory impairment were effectively alleviated by swimming exercise plus diet control, which was related to the increasing expression of SIRT1, inhibiting the expression of NF-κB and raising secretion of GnRH in the hypothalamus. These findings supported the hypothesis that hypothalamic inflammation was susceptible to exercise and diet, which was strongly associated with SIRT1-NF-κB-GnRH expression in the hypothalamus. |
| doi_str_mv | 10.18632/aging.103323 |
| format | Article |
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In order to explore the regulatory mechanisms of lifestyle in the hypothalamus, swimming exercise and diet control were applied in the high-fat diet ApoE-/- mice in our study. 20-week-old ApoE-/- mice fed with 12-week high-fat diet were treated by high-fat diet, diet control and swimming exercise. The results showed that hypothalamic inflammation, glial cells activation and cognition decline were induced by high-fat diet. Compared with the diet control, hypothalamic inflammation, glial cells activation and learning and memory impairment were effectively alleviated by swimming exercise plus diet control, which was related to the increasing expression of SIRT1, inhibiting the expression of NF-κB and raising secretion of GnRH in the hypothalamus. These findings supported the hypothesis that hypothalamic inflammation was susceptible to exercise and diet, which was strongly associated with SIRT1-NF-κB-GnRH expression in the hypothalamus.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.103323</identifier><identifier>PMID: 32518216</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Animals ; Diet, High-Fat ; Gonadotropin-Releasing Hormone - metabolism ; Hypothalamus - metabolism ; Hypothalamus - pathology ; Inflammation Mediators - metabolism ; Male ; Mice ; Mice, Knockout, ApoE ; NF-kappa B - metabolism ; Obesity - metabolism ; Physical Conditioning, Animal ; Research Paper ; Sirtuin 1 - metabolism ; Swimming</subject><ispartof>Aging (Albany, NY.), 2020-06, Vol.12 (11), p.11085-11099</ispartof><rights>Copyright © 2020 Wang et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-91b0c165c5fab96d542adc19e85ff053c341796f864879783804376e7d88ad4d3</citedby><cites>FETCH-LOGICAL-c387t-91b0c165c5fab96d542adc19e85ff053c341796f864879783804376e7d88ad4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346084/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346084/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32518216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xialei</creatorcontrib><creatorcontrib>Yang, Jingda</creatorcontrib><creatorcontrib>Lu, Taotao</creatorcontrib><creatorcontrib>Zhan, Zengtu</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Lyu, Xinru</creatorcontrib><creatorcontrib>Jiang, Yijing</creatorcontrib><creatorcontrib>Xue, Xiehua</creatorcontrib><title>The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>A high-fat diet and sedentary lifestyle could accelerate aging and hypothalamic inflammation. In order to explore the regulatory mechanisms of lifestyle in the hypothalamus, swimming exercise and diet control were applied in the high-fat diet ApoE-/- mice in our study. 20-week-old ApoE-/- mice fed with 12-week high-fat diet were treated by high-fat diet, diet control and swimming exercise. The results showed that hypothalamic inflammation, glial cells activation and cognition decline were induced by high-fat diet. Compared with the diet control, hypothalamic inflammation, glial cells activation and learning and memory impairment were effectively alleviated by swimming exercise plus diet control, which was related to the increasing expression of SIRT1, inhibiting the expression of NF-κB and raising secretion of GnRH in the hypothalamus. 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In order to explore the regulatory mechanisms of lifestyle in the hypothalamus, swimming exercise and diet control were applied in the high-fat diet ApoE-/- mice in our study. 20-week-old ApoE-/- mice fed with 12-week high-fat diet were treated by high-fat diet, diet control and swimming exercise. The results showed that hypothalamic inflammation, glial cells activation and cognition decline were induced by high-fat diet. Compared with the diet control, hypothalamic inflammation, glial cells activation and learning and memory impairment were effectively alleviated by swimming exercise plus diet control, which was related to the increasing expression of SIRT1, inhibiting the expression of NF-κB and raising secretion of GnRH in the hypothalamus. 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| source | MEDLINE; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Animals Diet, High-Fat Gonadotropin-Releasing Hormone - metabolism Hypothalamus - metabolism Hypothalamus - pathology Inflammation Mediators - metabolism Male Mice Mice, Knockout, ApoE NF-kappa B - metabolism Obesity - metabolism Physical Conditioning, Animal Research Paper Sirtuin 1 - metabolism Swimming |
| title | The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression |
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