Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits
This study was designed to evaluate the accuracy of detecting pulmonary embolism (PE) using the Technegas SPECT/CT combined with 68Ga PET/CT in a rabbit model. One hour after artificial PE (n = 6) and sham (n = 6) models were created, Technegas SPECT/CT ventilation and 68Ga-MAA PET/CT perfusion scan...
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| Veröffentlicht in: | Contrast media and molecular imaging 2020, Vol.2020 (2020), p.1-8 |
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| creator | Bir, Ferda Uğur, Ayşe Çayır, Mustafa Çağdaş Gültekin, Aziz Yuksel, Dogangun |
| description | This study was designed to evaluate the accuracy of detecting pulmonary embolism (PE) using the Technegas SPECT/CT combined with 68Ga PET/CT in a rabbit model. One hour after artificial PE (n = 6) and sham (n = 6) models were created, Technegas SPECT/CT ventilation and 68Ga-MAA PET/CT perfusion scan (V/Q scan) were performed. Ventilation imaging was performed first on all cases. Technegas SPECT/CT and 68Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard. A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity, and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68Ga-MAA PET/CT V/Q scans. Technegas/68Ga-MAA V/Q scans have good sensitivity, specificity, and accuracy in the detection of PE in this animal model study. |
| doi_str_mv | 10.1155/2020/5607951 |
| format | Article |
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One hour after artificial PE (n = 6) and sham (n = 6) models were created, Technegas SPECT/CT ventilation and 68Ga-MAA PET/CT perfusion scan (V/Q scan) were performed. Ventilation imaging was performed first on all cases. Technegas SPECT/CT and 68Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard. A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity, and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68Ga-MAA PET/CT V/Q scans. Technegas/68Ga-MAA V/Q scans have good sensitivity, specificity, and accuracy in the detection of PE in this animal model study.</description><identifier>ISSN: 1555-4309</identifier><identifier>EISSN: 1555-4317</identifier><identifier>DOI: 10.1155/2020/5607951</identifier><identifier>PMID: 32694958</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Albumins ; Animal models ; Computed tomography ; Defects ; Drug dosages ; Embolism ; Gallium ; Labeling ; Lobes ; Medical research ; Nuclear medicine ; Perfusion ; Positron emission ; Pulmonary arteries ; Pulmonary embolisms ; Rabbits ; Scanning electron microscopy ; Sensitivity analysis ; Single photon emission computed tomography ; Studies ; Tomography ; Veins & arteries ; Ventilation</subject><ispartof>Contrast media and molecular imaging, 2020, Vol.2020 (2020), p.1-8</ispartof><rights>Copyright © 2020 Aziz Gültekin et al.</rights><rights>Copyright © 2020 Aziz Gültekin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Aziz Gültekin et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-6523c0fb0af59c3e48cd3610c97d128e5d2292fd77596226245a8a9c345aeb523</citedby><cites>FETCH-LOGICAL-c448t-6523c0fb0af59c3e48cd3610c97d128e5d2292fd77596226245a8a9c345aeb523</cites><orcidid>0000-0002-0311-8077</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345963/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345963/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4009,27902,27903,27904,53769,53771</link.rule.ids></links><search><contributor>Ferro-Flores, Guillermina</contributor><contributor>Guillermina Ferro-Flores</contributor><creatorcontrib>Bir, Ferda</creatorcontrib><creatorcontrib>Uğur, Ayşe</creatorcontrib><creatorcontrib>Çayır, Mustafa Çağdaş</creatorcontrib><creatorcontrib>Gültekin, Aziz</creatorcontrib><creatorcontrib>Yuksel, Dogangun</creatorcontrib><title>Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits</title><title>Contrast media and molecular imaging</title><description>This study was designed to evaluate the accuracy of detecting pulmonary embolism (PE) using the Technegas SPECT/CT combined with 68Ga PET/CT in a rabbit model. One hour after artificial PE (n = 6) and sham (n = 6) models were created, Technegas SPECT/CT ventilation and 68Ga-MAA PET/CT perfusion scan (V/Q scan) were performed. Ventilation imaging was performed first on all cases. Technegas SPECT/CT and 68Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard. A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity, and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68Ga-MAA PET/CT V/Q scans. Technegas/68Ga-MAA V/Q scans have good sensitivity, specificity, and accuracy in the detection of PE in this animal model study.</description><subject>Albumins</subject><subject>Animal models</subject><subject>Computed tomography</subject><subject>Defects</subject><subject>Drug dosages</subject><subject>Embolism</subject><subject>Gallium</subject><subject>Labeling</subject><subject>Lobes</subject><subject>Medical research</subject><subject>Nuclear medicine</subject><subject>Perfusion</subject><subject>Positron emission</subject><subject>Pulmonary arteries</subject><subject>Pulmonary embolisms</subject><subject>Rabbits</subject><subject>Scanning electron microscopy</subject><subject>Sensitivity analysis</subject><subject>Single photon emission computed tomography</subject><subject>Studies</subject><subject>Tomography</subject><subject>Veins & arteries</subject><subject>Ventilation</subject><issn>1555-4309</issn><issn>1555-4317</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc2LEzEYh4Mo7ofePEvAi7COzfdM9iCUWldhxaL1HDIzmTZLJqlJxnX9601tWdGLpzfkffLwe_MC8Ayj1xhzPiOIoBkXqJYcPwCn5YpXjOL64f0ZyRNwltINQoxRSR-DE0qEZJI3p-DnW5NNl23wMAxwNbkxeB3v4HJsg7NphLc2b-GVds5OYyUa-FF3MejNJpqNzqaHc9dOo_VwZeIwpb1ntVzPFutLOPdw-WNnoh2Nz9rBL3nq72BBP-u2tTk9AY8G7ZJ5eqzn4Ou75Xrxvrr-dPVhMb-uOsaaXAlOaIeGFumBy44a1nQ9FRh1su4xaQzvCZFk6OuaS0GIIIzrRheyVNOWx-fgzcG7m9rR9F1JE7VTuxKsTKqCturvjrdbtQnfVV0UUtAieHkUxPBtMimr0abOOKe9CVNShBGBa0l-oy_-QW_CFH0Zb08VX4MkK9SrA1W-MqVohvswGKn9UtV-qeq41IJfHPCt9b2-tf-jnx9oUxgz6D80piVjQ38BDx6pew</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Bir, Ferda</creator><creator>Uğur, Ayşe</creator><creator>Çayır, Mustafa Çağdaş</creator><creator>Gültekin, Aziz</creator><creator>Yuksel, Dogangun</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0311-8077</orcidid></search><sort><creationdate>2020</creationdate><title>Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits</title><author>Bir, Ferda ; Uğur, Ayşe ; Çayır, Mustafa Çağdaş ; Gültekin, Aziz ; Yuksel, Dogangun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-6523c0fb0af59c3e48cd3610c97d128e5d2292fd77596226245a8a9c345aeb523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Albumins</topic><topic>Animal models</topic><topic>Computed tomography</topic><topic>Defects</topic><topic>Drug dosages</topic><topic>Embolism</topic><topic>Gallium</topic><topic>Labeling</topic><topic>Lobes</topic><topic>Medical research</topic><topic>Nuclear medicine</topic><topic>Perfusion</topic><topic>Positron emission</topic><topic>Pulmonary arteries</topic><topic>Pulmonary embolisms</topic><topic>Rabbits</topic><topic>Scanning electron microscopy</topic><topic>Sensitivity analysis</topic><topic>Single photon emission computed tomography</topic><topic>Studies</topic><topic>Tomography</topic><topic>Veins & arteries</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bir, Ferda</creatorcontrib><creatorcontrib>Uğur, Ayşe</creatorcontrib><creatorcontrib>Çayır, Mustafa Çağdaş</creatorcontrib><creatorcontrib>Gültekin, Aziz</creatorcontrib><creatorcontrib>Yuksel, Dogangun</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Contrast media and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bir, Ferda</au><au>Uğur, Ayşe</au><au>Çayır, Mustafa Çağdaş</au><au>Gültekin, Aziz</au><au>Yuksel, Dogangun</au><au>Ferro-Flores, Guillermina</au><au>Guillermina Ferro-Flores</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits</atitle><jtitle>Contrast media and molecular imaging</jtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1555-4309</issn><eissn>1555-4317</eissn><abstract>This study was designed to evaluate the accuracy of detecting pulmonary embolism (PE) using the Technegas SPECT/CT combined with 68Ga PET/CT in a rabbit model. One hour after artificial PE (n = 6) and sham (n = 6) models were created, Technegas SPECT/CT ventilation and 68Ga-MAA PET/CT perfusion scan (V/Q scan) were performed. Ventilation imaging was performed first on all cases. Technegas SPECT/CT and 68Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard. A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity, and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68Ga-MAA PET/CT V/Q scans. Technegas/68Ga-MAA V/Q scans have good sensitivity, specificity, and accuracy in the detection of PE in this animal model study.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32694958</pmid><doi>10.1155/2020/5607951</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0311-8077</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Albumins Animal models Computed tomography Defects Drug dosages Embolism Gallium Labeling Lobes Medical research Nuclear medicine Perfusion Positron emission Pulmonary arteries Pulmonary embolisms Rabbits Scanning electron microscopy Sensitivity analysis Single photon emission computed tomography Studies Tomography Veins & arteries Ventilation |
| title | Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits |
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