Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin

Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR), which functions to transport IgA t...

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Veröffentlicht in:	Cell research 2020-07, Vol.30 (7), p.602-609
Hauptverfasser:	Wang, Yuxin, Wang, Guopeng, Li, Yaxin, Zhu, Qinyu, Shen, Hao, Gao, Ning, Xiao, Junyu
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/250 631/535/1258/1259 Antibodies Biomedical and Life Sciences Cell Biology Electron microscopy Immunoglobulin A Immunoglobulins Life Sciences Mucosa Pathogenesis Secretory component Streptococcus infections Streptococcus pneumoniae
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