Secreted frizzled-related protein 2 prevents pressure-overload-induced cardiac hypertrophy by targeting the Wnt/β-catenin pathway

Background and aim Secreted frizzled-related protein 2 (sFRP2) has been reported to be involved in cardiovascular diseases. However, its role in cardiac hypertrophy induced by pressure overload is still elusive. We aimed to examine the role of sFRP2 in the development of cardiac hypertrophy in vivo...

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Veröffentlicht in:	Molecular and cellular biochemistry 2020-09, Vol.472 (1-2), p.241-251
Hauptverfasser:	Wei, Wen-Ying, Zhao, Qing, Zhang, Wen-zhong, Wang, Mao-jing, Li, Yan, Wang, Shi-zhong, Zhang, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Aorta Apoptosis beta Catenin - genetics beta Catenin - metabolism Biochemistry Biomedical and Life Sciences Body weight Cardiology Cardiomegaly - etiology Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - prevention & control Cardiomyocytes Cardiovascular diseases Collagen Disease Models, Animal Fibrosis Frizzled protein Frizzled-related protein Heart Hypertrophy In vitro methods and tests In vivo methods and tests Life Sciences Lithium chloride Male Medical Biochemistry Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Myocardium Myocytes Oncology Overloading Pressure Proteins Rats Rats, Sprague-Dawley Secreted frizzled-related protein 2 Ventricle Viruses Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism β-Catenin
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