Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks

Abstract DNA double-stranded breaks (DSBs) trigger human genome instability, therefore identifying what factors contribute to DSB induction is critical for our understanding of human disease etiology. Using an unbiased, genome-wide approach, we found that genomic regions with the ability to form hig...

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Veröffentlicht in:	Nucleic acids research 2020-07, Vol.48 (12), p.6654-6671
Hauptverfasser:	Szlachta, Karol, Manukyan, Arkadi, Raimer, Heather M, Singh, Sandeep, Salamon, Anita, Guo, Wenying, Lobachev, Kirill S, Wang, Yuh-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - genetics CCCTC-Binding Factor - genetics DNA - genetics DNA - ultrastructure DNA Breaks, Double-Stranded - drug effects DNA Repair - genetics DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - ultrastructure Etoposide - pharmacology Genome Integrity, Repair and Genome, Human - genetics Genomic Instability - genetics Humans Nucleic Acid Conformation - drug effects Transcription Initiation Site - drug effects
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