SARS-CoV-2 Screening Test for Japanese Returnees From Wuhan, China, January 2020
Abstract Background Severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2) was found to be the causative microorganism of coronavirus disease 2019 (COVID-19), which started to spread in Wuhan, China. This study was to evaluate the effectiveness of questionnaire, symptoms-based screenin...
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| Veröffentlicht in: | Open Forum Infectious Diseases 2020-07, Vol.7 (7), p.ofaa243-ofaa243 |
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| creator | Kutsuna, Satoshi Suzuki, Tadaki Hayakawa, Kayoko Tsuzuki, Shinya Asai, Yusuke Suzuki, Tetsuya Ide, Satoshi Nakamura, Keiji Moriyama, Yuki Kinoshita, Noriko Hosokawa, Naoto Osawa, Ryosuke Yamamuro, Ryosuke Akiyama, Yutaro Miyazato, Yusuke Nomoto, Hidetoshi Nakamoto, Takato Ota, Masayuki Saito, Sho Ishikane, Masahiro Morioka, Shinichiro Yamamoto, Kei Ujiie, Mugen Terada, Mari Nakamura-Uchiyama, Fukumi Sahara, Toshinori Sano, Masahiro Imamura, Akifumi Sekiya, Noritaka Fukushima, Kazuaki Kawana, Akihiko Fujikura, Yuji Sano, Tomoya Suematsu, Ryohei Sakamoto, Naoya Nagata, Kaoru Kato, Tomoyuki Katano, Harutaka Wakita, Takaji Sugiyama, Haruhito Kokudo, Norihiro Ohmagari, Norio |
| description | Abstract
Background
Severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2) was found to be the causative microorganism of coronavirus disease 2019 (COVID-19), which started to spread in Wuhan, China. This study was to evaluate the effectiveness of questionnaire, symptoms-based screening, and polymerase chain reaction (PCR) screening of returnees from COVID-19-endemic areas on a chartered flight, to examine the proportion of infected persons and the proportion of asymptomatic persons among infected persons who returned from Wuhan.
Methods
A retrospective cohort study was done in 7 tertiary medical institutions in Japan. A total of 566 Japanese who returned from Wuhan participated in the study.
Results
Overall, 11 of the 566 passengers had a positive SARS-CoV-2 PCR result for pharyngeal swabs and 6 were asymptomatic. Only fever differed between SARS-CoV-2-positive and -negative individuals (P < .043). Six of the 11 PCR-positive individuals were asymptomatic; 4 remained positive on day 10, and 1 asymptomatic person tested positive up to day 27. Two of the 11 were negative on the first PCR test and positive on the second.
Conclusions
Our results will be important insights on screening returnees from locked-down cities, as well as providing important data on the proportion of asymptomatic individuals infected with SARS-CoV-2. A 13-day observation period and a second round of PCR may be effective to screen patients, including asymptomatic infections. |
| doi_str_mv | 10.1093/ofid/ofaa243 |
| format | Article |
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Background
Severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2) was found to be the causative microorganism of coronavirus disease 2019 (COVID-19), which started to spread in Wuhan, China. This study was to evaluate the effectiveness of questionnaire, symptoms-based screening, and polymerase chain reaction (PCR) screening of returnees from COVID-19-endemic areas on a chartered flight, to examine the proportion of infected persons and the proportion of asymptomatic persons among infected persons who returned from Wuhan.
Methods
A retrospective cohort study was done in 7 tertiary medical institutions in Japan. A total of 566 Japanese who returned from Wuhan participated in the study.
Results
Overall, 11 of the 566 passengers had a positive SARS-CoV-2 PCR result for pharyngeal swabs and 6 were asymptomatic. Only fever differed between SARS-CoV-2-positive and -negative individuals (P < .043). Six of the 11 PCR-positive individuals were asymptomatic; 4 remained positive on day 10, and 1 asymptomatic person tested positive up to day 27. Two of the 11 were negative on the first PCR test and positive on the second.
Conclusions
Our results will be important insights on screening returnees from locked-down cities, as well as providing important data on the proportion of asymptomatic individuals infected with SARS-CoV-2. A 13-day observation period and a second round of PCR may be effective to screen patients, including asymptomatic infections.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofaa243</identifier><identifier>PMID: 32754627</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Charter airlines ; Coronaviruses ; Health aspects ; Major ; Medical screening ; Medical tests ; Severe acute respiratory syndrome</subject><ispartof>Open Forum Infectious Diseases, 2020-07, Vol.7 (7), p.ofaa243-ofaa243</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-e97bd112bfab7430099da1212a6ffa63587255cdfbd213c60af0f9009c9a75563</citedby><cites>FETCH-LOGICAL-c577t-e97bd112bfab7430099da1212a6ffa63587255cdfbd213c60af0f9009c9a75563</cites><orcidid>0000-0002-4622-8970</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337761/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337761/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1604,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32754627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kutsuna, Satoshi</creatorcontrib><creatorcontrib>Suzuki, Tadaki</creatorcontrib><creatorcontrib>Hayakawa, Kayoko</creatorcontrib><creatorcontrib>Tsuzuki, Shinya</creatorcontrib><creatorcontrib>Asai, Yusuke</creatorcontrib><creatorcontrib>Suzuki, Tetsuya</creatorcontrib><creatorcontrib>Ide, Satoshi</creatorcontrib><creatorcontrib>Nakamura, Keiji</creatorcontrib><creatorcontrib>Moriyama, Yuki</creatorcontrib><creatorcontrib>Kinoshita, Noriko</creatorcontrib><creatorcontrib>Hosokawa, Naoto</creatorcontrib><creatorcontrib>Osawa, Ryosuke</creatorcontrib><creatorcontrib>Yamamuro, Ryosuke</creatorcontrib><creatorcontrib>Akiyama, Yutaro</creatorcontrib><creatorcontrib>Miyazato, Yusuke</creatorcontrib><creatorcontrib>Nomoto, Hidetoshi</creatorcontrib><creatorcontrib>Nakamoto, Takato</creatorcontrib><creatorcontrib>Ota, Masayuki</creatorcontrib><creatorcontrib>Saito, Sho</creatorcontrib><creatorcontrib>Ishikane, Masahiro</creatorcontrib><creatorcontrib>Morioka, Shinichiro</creatorcontrib><creatorcontrib>Yamamoto, Kei</creatorcontrib><creatorcontrib>Ujiie, Mugen</creatorcontrib><creatorcontrib>Terada, Mari</creatorcontrib><creatorcontrib>Nakamura-Uchiyama, Fukumi</creatorcontrib><creatorcontrib>Sahara, Toshinori</creatorcontrib><creatorcontrib>Sano, Masahiro</creatorcontrib><creatorcontrib>Imamura, Akifumi</creatorcontrib><creatorcontrib>Sekiya, Noritaka</creatorcontrib><creatorcontrib>Fukushima, Kazuaki</creatorcontrib><creatorcontrib>Kawana, Akihiko</creatorcontrib><creatorcontrib>Fujikura, Yuji</creatorcontrib><creatorcontrib>Sano, Tomoya</creatorcontrib><creatorcontrib>Suematsu, Ryohei</creatorcontrib><creatorcontrib>Sakamoto, Naoya</creatorcontrib><creatorcontrib>Nagata, Kaoru</creatorcontrib><creatorcontrib>Kato, Tomoyuki</creatorcontrib><creatorcontrib>Katano, Harutaka</creatorcontrib><creatorcontrib>Wakita, Takaji</creatorcontrib><creatorcontrib>Sugiyama, Haruhito</creatorcontrib><creatorcontrib>Kokudo, Norihiro</creatorcontrib><creatorcontrib>Ohmagari, Norio</creatorcontrib><title>SARS-CoV-2 Screening Test for Japanese Returnees From Wuhan, China, January 2020</title><title>Open Forum Infectious Diseases</title><addtitle>Open Forum Infect Dis</addtitle><description>Abstract
Background
Severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2) was found to be the causative microorganism of coronavirus disease 2019 (COVID-19), which started to spread in Wuhan, China. This study was to evaluate the effectiveness of questionnaire, symptoms-based screening, and polymerase chain reaction (PCR) screening of returnees from COVID-19-endemic areas on a chartered flight, to examine the proportion of infected persons and the proportion of asymptomatic persons among infected persons who returned from Wuhan.
Methods
A retrospective cohort study was done in 7 tertiary medical institutions in Japan. A total of 566 Japanese who returned from Wuhan participated in the study.
Results
Overall, 11 of the 566 passengers had a positive SARS-CoV-2 PCR result for pharyngeal swabs and 6 were asymptomatic. Only fever differed between SARS-CoV-2-positive and -negative individuals (P < .043). Six of the 11 PCR-positive individuals were asymptomatic; 4 remained positive on day 10, and 1 asymptomatic person tested positive up to day 27. Two of the 11 were negative on the first PCR test and positive on the second.
Conclusions
Our results will be important insights on screening returnees from locked-down cities, as well as providing important data on the proportion of asymptomatic individuals infected with SARS-CoV-2. A 13-day observation period and a second round of PCR may be effective to screen patients, including asymptomatic infections.</description><subject>Charter airlines</subject><subject>Coronaviruses</subject><subject>Health aspects</subject><subject>Major</subject><subject>Medical screening</subject><subject>Medical tests</subject><subject>Severe acute respiratory 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Satoshi</creator><creator>Nakamura, Keiji</creator><creator>Moriyama, Yuki</creator><creator>Kinoshita, Noriko</creator><creator>Hosokawa, Naoto</creator><creator>Osawa, Ryosuke</creator><creator>Yamamuro, Ryosuke</creator><creator>Akiyama, Yutaro</creator><creator>Miyazato, Yusuke</creator><creator>Nomoto, Hidetoshi</creator><creator>Nakamoto, Takato</creator><creator>Ota, Masayuki</creator><creator>Saito, Sho</creator><creator>Ishikane, Masahiro</creator><creator>Morioka, Shinichiro</creator><creator>Yamamoto, Kei</creator><creator>Ujiie, Mugen</creator><creator>Terada, Mari</creator><creator>Nakamura-Uchiyama, Fukumi</creator><creator>Sahara, Toshinori</creator><creator>Sano, Masahiro</creator><creator>Imamura, Akifumi</creator><creator>Sekiya, Noritaka</creator><creator>Fukushima, Kazuaki</creator><creator>Kawana, Akihiko</creator><creator>Fujikura, Yuji</creator><creator>Sano, Tomoya</creator><creator>Suematsu, Ryohei</creator><creator>Sakamoto, Naoya</creator><creator>Nagata, Kaoru</creator><creator>Kato, Tomoyuki</creator><creator>Katano, Harutaka</creator><creator>Wakita, Takaji</creator><creator>Sugiyama, Haruhito</creator><creator>Kokudo, Norihiro</creator><creator>Ohmagari, Norio</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4622-8970</orcidid></search><sort><creationdate>20200701</creationdate><title>SARS-CoV-2 Screening Test for Japanese Returnees From Wuhan, China, January 2020</title><author>Kutsuna, Satoshi ; Suzuki, Tadaki ; Hayakawa, Kayoko ; Tsuzuki, Shinya ; Asai, Yusuke ; Suzuki, Tetsuya ; Ide, Satoshi ; Nakamura, Keiji ; Moriyama, Yuki ; Kinoshita, Noriko ; Hosokawa, Naoto ; Osawa, Ryosuke ; Yamamuro, Ryosuke ; Akiyama, Yutaro ; Miyazato, Yusuke ; Nomoto, Hidetoshi ; Nakamoto, Takato ; Ota, Masayuki ; Saito, Sho ; Ishikane, Masahiro ; Morioka, Shinichiro ; Yamamoto, Kei ; Ujiie, Mugen ; Terada, Mari ; Nakamura-Uchiyama, Fukumi ; Sahara, Toshinori ; Sano, Masahiro ; Imamura, Akifumi ; Sekiya, Noritaka ; Fukushima, Kazuaki ; Kawana, Akihiko ; Fujikura, Yuji ; Sano, Tomoya ; Suematsu, Ryohei ; Sakamoto, Naoya ; Nagata, Kaoru ; Kato, Tomoyuki ; Katano, Harutaka ; Wakita, Takaji ; Sugiyama, Haruhito ; Kokudo, Norihiro ; Ohmagari, Norio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-e97bd112bfab7430099da1212a6ffa63587255cdfbd213c60af0f9009c9a75563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Charter airlines</topic><topic>Coronaviruses</topic><topic>Health aspects</topic><topic>Major</topic><topic>Medical screening</topic><topic>Medical tests</topic><topic>Severe acute respiratory syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kutsuna, Satoshi</creatorcontrib><creatorcontrib>Suzuki, Tadaki</creatorcontrib><creatorcontrib>Hayakawa, Kayoko</creatorcontrib><creatorcontrib>Tsuzuki, Shinya</creatorcontrib><creatorcontrib>Asai, Yusuke</creatorcontrib><creatorcontrib>Suzuki, Tetsuya</creatorcontrib><creatorcontrib>Ide, Satoshi</creatorcontrib><creatorcontrib>Nakamura, Keiji</creatorcontrib><creatorcontrib>Moriyama, Yuki</creatorcontrib><creatorcontrib>Kinoshita, Noriko</creatorcontrib><creatorcontrib>Hosokawa, Naoto</creatorcontrib><creatorcontrib>Osawa, Ryosuke</creatorcontrib><creatorcontrib>Yamamuro, Ryosuke</creatorcontrib><creatorcontrib>Akiyama, Yutaro</creatorcontrib><creatorcontrib>Miyazato, Yusuke</creatorcontrib><creatorcontrib>Nomoto, Hidetoshi</creatorcontrib><creatorcontrib>Nakamoto, Takato</creatorcontrib><creatorcontrib>Ota, Masayuki</creatorcontrib><creatorcontrib>Saito, Sho</creatorcontrib><creatorcontrib>Ishikane, Masahiro</creatorcontrib><creatorcontrib>Morioka, Shinichiro</creatorcontrib><creatorcontrib>Yamamoto, Kei</creatorcontrib><creatorcontrib>Ujiie, Mugen</creatorcontrib><creatorcontrib>Terada, Mari</creatorcontrib><creatorcontrib>Nakamura-Uchiyama, Fukumi</creatorcontrib><creatorcontrib>Sahara, Toshinori</creatorcontrib><creatorcontrib>Sano, Masahiro</creatorcontrib><creatorcontrib>Imamura, Akifumi</creatorcontrib><creatorcontrib>Sekiya, Noritaka</creatorcontrib><creatorcontrib>Fukushima, Kazuaki</creatorcontrib><creatorcontrib>Kawana, Akihiko</creatorcontrib><creatorcontrib>Fujikura, Yuji</creatorcontrib><creatorcontrib>Sano, Tomoya</creatorcontrib><creatorcontrib>Suematsu, Ryohei</creatorcontrib><creatorcontrib>Sakamoto, Naoya</creatorcontrib><creatorcontrib>Nagata, Kaoru</creatorcontrib><creatorcontrib>Kato, Tomoyuki</creatorcontrib><creatorcontrib>Katano, Harutaka</creatorcontrib><creatorcontrib>Wakita, Takaji</creatorcontrib><creatorcontrib>Sugiyama, Haruhito</creatorcontrib><creatorcontrib>Kokudo, Norihiro</creatorcontrib><creatorcontrib>Ohmagari, Norio</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kutsuna, Satoshi</au><au>Suzuki, Tadaki</au><au>Hayakawa, Kayoko</au><au>Tsuzuki, Shinya</au><au>Asai, Yusuke</au><au>Suzuki, Tetsuya</au><au>Ide, Satoshi</au><au>Nakamura, Keiji</au><au>Moriyama, Yuki</au><au>Kinoshita, Noriko</au><au>Hosokawa, Naoto</au><au>Osawa, Ryosuke</au><au>Yamamuro, Ryosuke</au><au>Akiyama, Yutaro</au><au>Miyazato, Yusuke</au><au>Nomoto, Hidetoshi</au><au>Nakamoto, Takato</au><au>Ota, Masayuki</au><au>Saito, Sho</au><au>Ishikane, Masahiro</au><au>Morioka, Shinichiro</au><au>Yamamoto, Kei</au><au>Ujiie, Mugen</au><au>Terada, Mari</au><au>Nakamura-Uchiyama, Fukumi</au><au>Sahara, Toshinori</au><au>Sano, Masahiro</au><au>Imamura, Akifumi</au><au>Sekiya, Noritaka</au><au>Fukushima, Kazuaki</au><au>Kawana, Akihiko</au><au>Fujikura, Yuji</au><au>Sano, Tomoya</au><au>Suematsu, Ryohei</au><au>Sakamoto, Naoya</au><au>Nagata, Kaoru</au><au>Kato, Tomoyuki</au><au>Katano, Harutaka</au><au>Wakita, Takaji</au><au>Sugiyama, Haruhito</au><au>Kokudo, Norihiro</au><au>Ohmagari, Norio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SARS-CoV-2 Screening Test for Japanese Returnees From Wuhan, China, January 2020</atitle><jtitle>Open Forum Infectious Diseases</jtitle><addtitle>Open Forum Infect Dis</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>7</volume><issue>7</issue><spage>ofaa243</spage><epage>ofaa243</epage><pages>ofaa243-ofaa243</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Background
Severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2) was found to be the causative microorganism of coronavirus disease 2019 (COVID-19), which started to spread in Wuhan, China. This study was to evaluate the effectiveness of questionnaire, symptoms-based screening, and polymerase chain reaction (PCR) screening of returnees from COVID-19-endemic areas on a chartered flight, to examine the proportion of infected persons and the proportion of asymptomatic persons among infected persons who returned from Wuhan.
Methods
A retrospective cohort study was done in 7 tertiary medical institutions in Japan. A total of 566 Japanese who returned from Wuhan participated in the study.
Results
Overall, 11 of the 566 passengers had a positive SARS-CoV-2 PCR result for pharyngeal swabs and 6 were asymptomatic. Only fever differed between SARS-CoV-2-positive and -negative individuals (P < .043). Six of the 11 PCR-positive individuals were asymptomatic; 4 remained positive on day 10, and 1 asymptomatic person tested positive up to day 27. Two of the 11 were negative on the first PCR test and positive on the second.
Conclusions
Our results will be important insights on screening returnees from locked-down cities, as well as providing important data on the proportion of asymptomatic individuals infected with SARS-CoV-2. A 13-day observation period and a second round of PCR may be effective to screen patients, including asymptomatic infections.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32754627</pmid><doi>10.1093/ofid/ofaa243</doi><orcidid>https://orcid.org/0000-0002-4622-8970</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2328-8957 |
| ispartof | Open Forum Infectious Diseases, 2020-07, Vol.7 (7), p.ofaa243-ofaa243 |
| issn | 2328-8957 2328-8957 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7337761 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Charter airlines Coronaviruses Health aspects Major Medical screening Medical tests Severe acute respiratory syndrome |
| title | SARS-CoV-2 Screening Test for Japanese Returnees From Wuhan, China, January 2020 |
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